Autophagy within the mushroom body protects from synapse aging in a non-cell autonomous manner

The role of macroautophagy in neuronal processes mediating brain maintenance remains enigmatic. Authors show here that impairing autophagy within the major learning related brain center of Drosophila, and not other regions, triggered a form of presynaptic metaplasticity that was invariably connected...

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Autores principales:	Anuradha Bhukel, Christine Brigitte Beuschel, Marta Maglione, Martin Lehmann, Gabor Juhász, Frank Madeo, Stephan J. Sigrist
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1f427542d72747999346bfa2f3bdd184
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spelling	oai:doaj.org-article:1f427542d72747999346bfa2f3bdd1842021-12-02T14:38:43ZAutophagy within the mushroom body protects from synapse aging in a non-cell autonomous manner10.1038/s41467-019-09262-22041-1723https://doaj.org/article/1f427542d72747999346bfa2f3bdd1842019-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09262-2https://doaj.org/toc/2041-1723The role of macroautophagy in neuronal processes mediating brain maintenance remains enigmatic. Authors show here that impairing autophagy within the major learning related brain center of Drosophila, and not other regions, triggered a form of presynaptic metaplasticity that was invariably connected to the absence of the specific component of aversive olfactory memory, which normally only declines in the course of aging processAnuradha BhukelChristine Brigitte BeuschelMarta MaglioneMartin LehmannGabor JuhászFrank MadeoStephan J. SigristNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Anuradha Bhukel Christine Brigitte Beuschel Marta Maglione Martin Lehmann Gabor Juhász Frank Madeo Stephan J. Sigrist Autophagy within the mushroom body protects from synapse aging in a non-cell autonomous manner
description	The role of macroautophagy in neuronal processes mediating brain maintenance remains enigmatic. Authors show here that impairing autophagy within the major learning related brain center of Drosophila, and not other regions, triggered a form of presynaptic metaplasticity that was invariably connected to the absence of the specific component of aversive olfactory memory, which normally only declines in the course of aging process
format	article
author	Anuradha Bhukel Christine Brigitte Beuschel Marta Maglione Martin Lehmann Gabor Juhász Frank Madeo Stephan J. Sigrist
author_facet	Anuradha Bhukel Christine Brigitte Beuschel Marta Maglione Martin Lehmann Gabor Juhász Frank Madeo Stephan J. Sigrist
author_sort	Anuradha Bhukel
title	Autophagy within the mushroom body protects from synapse aging in a non-cell autonomous manner
title_short	Autophagy within the mushroom body protects from synapse aging in a non-cell autonomous manner
title_full	Autophagy within the mushroom body protects from synapse aging in a non-cell autonomous manner
title_fullStr	Autophagy within the mushroom body protects from synapse aging in a non-cell autonomous manner
title_full_unstemmed	Autophagy within the mushroom body protects from synapse aging in a non-cell autonomous manner
title_sort	autophagy within the mushroom body protects from synapse aging in a non-cell autonomous manner
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/1f427542d72747999346bfa2f3bdd184
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Autophagy within the mushroom body protects from synapse aging in a non-cell autonomous manner

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