Large scale discovery of coronavirus-host factor protein interaction motifs reveals SARS-CoV-2 specific mechanisms and vulnerabilities
Many interactions between viral and host proteins are mediated by short peptide motifs. Here, using a phage-based viral peptide library, the authors identify 269 peptide-based interactions for 18 coronaviruses, including an interaction between SARS-CoV-2 N and G3BP1/2 that affects stress granules.
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Nature Portfolio
2021
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oai:doaj.org-article:1f444706eff944aca145f8ed28412f902021-11-21T12:38:58ZLarge scale discovery of coronavirus-host factor protein interaction motifs reveals SARS-CoV-2 specific mechanisms and vulnerabilities10.1038/s41467-021-26498-z2041-1723https://doaj.org/article/1f444706eff944aca145f8ed28412f902021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26498-zhttps://doaj.org/toc/2041-1723Many interactions between viral and host proteins are mediated by short peptide motifs. Here, using a phage-based viral peptide library, the authors identify 269 peptide-based interactions for 18 coronaviruses, including an interaction between SARS-CoV-2 N and G3BP1/2 that affects stress granules.Thomas KruseCaroline BenzDimitriya H. GarvanskaRichard LindqvistFilip MihalicFabian CosciaRaviteja InturiAhmed SayadiLeandro SimonettiEmma NilssonMuhammad AliJohanna KlicheAinhoa Moliner MorroAndreas MundEva AnderssonGerald McInerneyMatthias MannPer JemthNorman E. DaveyAnna K. ÖverbyJakob NilssonYlva IvarssonNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Thomas Kruse Caroline Benz Dimitriya H. Garvanska Richard Lindqvist Filip Mihalic Fabian Coscia Raviteja Inturi Ahmed Sayadi Leandro Simonetti Emma Nilsson Muhammad Ali Johanna Kliche Ainhoa Moliner Morro Andreas Mund Eva Andersson Gerald McInerney Matthias Mann Per Jemth Norman E. Davey Anna K. Överby Jakob Nilsson Ylva Ivarsson Large scale discovery of coronavirus-host factor protein interaction motifs reveals SARS-CoV-2 specific mechanisms and vulnerabilities |
| description |
Many interactions between viral and host proteins are mediated by short peptide motifs. Here, using a phage-based viral peptide library, the authors identify 269 peptide-based interactions for 18 coronaviruses, including an interaction between SARS-CoV-2 N and G3BP1/2 that affects stress granules. |
| format |
article |
| author |
Thomas Kruse Caroline Benz Dimitriya H. Garvanska Richard Lindqvist Filip Mihalic Fabian Coscia Raviteja Inturi Ahmed Sayadi Leandro Simonetti Emma Nilsson Muhammad Ali Johanna Kliche Ainhoa Moliner Morro Andreas Mund Eva Andersson Gerald McInerney Matthias Mann Per Jemth Norman E. Davey Anna K. Överby Jakob Nilsson Ylva Ivarsson |
| author_facet |
Thomas Kruse Caroline Benz Dimitriya H. Garvanska Richard Lindqvist Filip Mihalic Fabian Coscia Raviteja Inturi Ahmed Sayadi Leandro Simonetti Emma Nilsson Muhammad Ali Johanna Kliche Ainhoa Moliner Morro Andreas Mund Eva Andersson Gerald McInerney Matthias Mann Per Jemth Norman E. Davey Anna K. Överby Jakob Nilsson Ylva Ivarsson |
| author_sort |
Thomas Kruse |
| title |
Large scale discovery of coronavirus-host factor protein interaction motifs reveals SARS-CoV-2 specific mechanisms and vulnerabilities |
| title_short |
Large scale discovery of coronavirus-host factor protein interaction motifs reveals SARS-CoV-2 specific mechanisms and vulnerabilities |
| title_full |
Large scale discovery of coronavirus-host factor protein interaction motifs reveals SARS-CoV-2 specific mechanisms and vulnerabilities |
| title_fullStr |
Large scale discovery of coronavirus-host factor protein interaction motifs reveals SARS-CoV-2 specific mechanisms and vulnerabilities |
| title_full_unstemmed |
Large scale discovery of coronavirus-host factor protein interaction motifs reveals SARS-CoV-2 specific mechanisms and vulnerabilities |
| title_sort |
large scale discovery of coronavirus-host factor protein interaction motifs reveals sars-cov-2 specific mechanisms and vulnerabilities |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/1f444706eff944aca145f8ed28412f90 |
| work_keys_str_mv |
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