Protein interaction potential landscapes for yeast replicative aging

Abstract We proposed a novel interaction potential landscape approach to map the systems-level profile changes of gene networks during replicative aging in Saccharomyces cerevisiae. This approach enabled us to apply quasi-potentials, the negative logarithm of the probabilities, to calibrate the elev...

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Autores principales:	Hao-Bo Guo, Mehran Ghafari, Weiwei Dang, Hong Qin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1f4ae4dfcc5347d9960cadfb3996025b
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spelling	oai:doaj.org-article:1f4ae4dfcc5347d9960cadfb3996025b2021-12-02T14:25:32ZProtein interaction potential landscapes for yeast replicative aging10.1038/s41598-021-86415-82045-2322https://doaj.org/article/1f4ae4dfcc5347d9960cadfb3996025b2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-86415-8https://doaj.org/toc/2045-2322Abstract We proposed a novel interaction potential landscape approach to map the systems-level profile changes of gene networks during replicative aging in Saccharomyces cerevisiae. This approach enabled us to apply quasi-potentials, the negative logarithm of the probabilities, to calibrate the elevation of the interaction landscapes with young cells as a reference state. Our approach detected opposite landscape changes based on protein abundances from transcript levels, especially for intra-essential gene interactions. We showed that essential proteins play different roles from hub proteins on the age-dependent interaction potential landscapes. We verified that hub proteins tend to avoid other hub proteins, but essential proteins prefer to interact with other essential proteins. Overall, we showed that the interaction potential landscape is promising for inferring network profile change during aging and that the essential hub proteins may play an important role in the uncoupling between protein and transcript levels during replicative aging.Hao-Bo GuoMehran GhafariWeiwei DangHong QinNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hao-Bo Guo Mehran Ghafari Weiwei Dang Hong Qin Protein interaction potential landscapes for yeast replicative aging
description	Abstract We proposed a novel interaction potential landscape approach to map the systems-level profile changes of gene networks during replicative aging in Saccharomyces cerevisiae. This approach enabled us to apply quasi-potentials, the negative logarithm of the probabilities, to calibrate the elevation of the interaction landscapes with young cells as a reference state. Our approach detected opposite landscape changes based on protein abundances from transcript levels, especially for intra-essential gene interactions. We showed that essential proteins play different roles from hub proteins on the age-dependent interaction potential landscapes. We verified that hub proteins tend to avoid other hub proteins, but essential proteins prefer to interact with other essential proteins. Overall, we showed that the interaction potential landscape is promising for inferring network profile change during aging and that the essential hub proteins may play an important role in the uncoupling between protein and transcript levels during replicative aging.
format	article
author	Hao-Bo Guo Mehran Ghafari Weiwei Dang Hong Qin
author_facet	Hao-Bo Guo Mehran Ghafari Weiwei Dang Hong Qin
author_sort	Hao-Bo Guo
title	Protein interaction potential landscapes for yeast replicative aging
title_short	Protein interaction potential landscapes for yeast replicative aging
title_full	Protein interaction potential landscapes for yeast replicative aging
title_fullStr	Protein interaction potential landscapes for yeast replicative aging
title_full_unstemmed	Protein interaction potential landscapes for yeast replicative aging
title_sort	protein interaction potential landscapes for yeast replicative aging
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/1f4ae4dfcc5347d9960cadfb3996025b
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_version_	1718391356808757248

Protein interaction potential landscapes for yeast replicative aging

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