Assessing a 6-h endpoint observation time in the lethality neutralization assay used to evaluate the preclinical efficacy of snake antivenoms
The lethality neutralization assay in mice is the gold standard for the evaluation of the preclinical efficacy and specification fulfillment of snake antivenoms. However, owing to the animal suffering involved, this assay is a candidate to be replaced by in vitro alternatives or, at least, improved...
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Autores principales: | Gina Durán, Gabriela Solano, Aarón Gómez, Daniel Cordero, Adriana Sánchez, Mauren Villalta, Melvin Sánchez, Cecilia Díaz, José María Gutiérrez, Guillermo León |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
Elsevier
2021
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Materias: | |
Acceso en línea: | https://doaj.org/article/1f4afb236e95440e81a6549442e93159 |
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