Differential grey matter changes in sensorimotor cortex related to exceptional fine motor skills.

Differential grey matter changes in sensorimotor cortex related to exceptional fine motor skills.

Functional changes in sensorimotor representation occur in response to use and lesion throughout life. Emerging evidence suggests that functional changes are paralleled by respective macroscopic structural changes. In the present study we used voxel-based morphometry to investigate sensorimotor cort...

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Autores principales: M Cornelia Stoeckel, Farina Morgenroth, Cathrin M Buetefisch, Rüdiger J Seitz
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2012
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Acceso en línea:https://doaj.org/article/1f4d977511a64a75a395d713b215f97c
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spelling oai:doaj.org-article:1f4d977511a64a75a395d713b215f97c2021-11-18T08:03:47ZDifferential grey matter changes in sensorimotor cortex related to exceptional fine motor skills.1932-620310.1371/journal.pone.0051900https://doaj.org/article/1f4d977511a64a75a395d713b215f97c2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23300575/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Functional changes in sensorimotor representation occur in response to use and lesion throughout life. Emerging evidence suggests that functional changes are paralleled by respective macroscopic structural changes. In the present study we used voxel-based morphometry to investigate sensorimotor cortex in subjects with congenitally malformed upper extremities. We expected increased or decreased grey matter to parallel the enlarged or reduced functional representations we reported previously. More specifically, we expected decreased grey matter values in lateral sensorimotor cortex related to compromised hand function and increased grey matter values in medial sensorimotor cortex due to compensatory foot use. We found a medial cluster of grey matter increase in subjects with frequent, hand-like compensatory foot use. This increase was predominantly seen for lateral premotor, supplementary motor, and motor areas and only marginally involved somatosensory cortex. Contrary to our expectation, subjects with a reduced number of fingers, who had shown shrinkage of the functional hand representation previously, did not show decreased grey matter values within lateral sensorimotor cortex. Our data suggest that functional plastic changes in sensorimotor cortex can be associated with increases in grey matter but may also occur in otherwise macroscopically normal appearing grey matter volumes. Furthermore, macroscopic structural changes in motor and premotor areas may be observed without respective changes in somatosensory cortex.M Cornelia StoeckelFarina MorgenrothCathrin M BuetefischRüdiger J SeitzPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 12, p e51900 (2012)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
M Cornelia Stoeckel
Farina Morgenroth
Cathrin M Buetefisch
Rüdiger J Seitz
Differential grey matter changes in sensorimotor cortex related to exceptional fine motor skills.
description Functional changes in sensorimotor representation occur in response to use and lesion throughout life. Emerging evidence suggests that functional changes are paralleled by respective macroscopic structural changes. In the present study we used voxel-based morphometry to investigate sensorimotor cortex in subjects with congenitally malformed upper extremities. We expected increased or decreased grey matter to parallel the enlarged or reduced functional representations we reported previously. More specifically, we expected decreased grey matter values in lateral sensorimotor cortex related to compromised hand function and increased grey matter values in medial sensorimotor cortex due to compensatory foot use. We found a medial cluster of grey matter increase in subjects with frequent, hand-like compensatory foot use. This increase was predominantly seen for lateral premotor, supplementary motor, and motor areas and only marginally involved somatosensory cortex. Contrary to our expectation, subjects with a reduced number of fingers, who had shown shrinkage of the functional hand representation previously, did not show decreased grey matter values within lateral sensorimotor cortex. Our data suggest that functional plastic changes in sensorimotor cortex can be associated with increases in grey matter but may also occur in otherwise macroscopically normal appearing grey matter volumes. Furthermore, macroscopic structural changes in motor and premotor areas may be observed without respective changes in somatosensory cortex.
format article
author M Cornelia Stoeckel
Farina Morgenroth
Cathrin M Buetefisch
Rüdiger J Seitz
author_facet M Cornelia Stoeckel
Farina Morgenroth
Cathrin M Buetefisch
Rüdiger J Seitz
author_sort M Cornelia Stoeckel
title Differential grey matter changes in sensorimotor cortex related to exceptional fine motor skills.
title_short Differential grey matter changes in sensorimotor cortex related to exceptional fine motor skills.
title_full Differential grey matter changes in sensorimotor cortex related to exceptional fine motor skills.
title_fullStr Differential grey matter changes in sensorimotor cortex related to exceptional fine motor skills.
title_full_unstemmed Differential grey matter changes in sensorimotor cortex related to exceptional fine motor skills.
title_sort differential grey matter changes in sensorimotor cortex related to exceptional fine motor skills.
publisher Public Library of Science (PLoS)
publishDate 2012
url https://doaj.org/article/1f4d977511a64a75a395d713b215f97c
work_keys_str_mv AT mcorneliastoeckel differentialgreymatterchangesinsensorimotorcortexrelatedtoexceptionalfinemotorskills
AT farinamorgenroth differentialgreymatterchangesinsensorimotorcortexrelatedtoexceptionalfinemotorskills
AT cathrinmbuetefisch differentialgreymatterchangesinsensorimotorcortexrelatedtoexceptionalfinemotorskills
AT rudigerjseitz differentialgreymatterchangesinsensorimotorcortexrelatedtoexceptionalfinemotorskills
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