ETS transcription factors induce a unique UV damage signature that drives recurrent mutagenesis in melanoma

Many factors contribute to mutation hotspots in cancer cells. Here the authors map UV damage at single-nucleotide resolution across the human genome and find that binding sites of ETS transcription factors are especially prone to forming UV lesions, leading to mutation hotspots in melanoma.

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Autores principales:	Peng Mao, Alexander J. Brown, Shingo Esaki, Svetlana Lockwood, Gregory M. K. Poon, Michael J. Smerdon, Steven A. Roberts, John J. Wyrick
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1f4e7dc1330c42998833ca4f03cc3b39
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spelling	oai:doaj.org-article:1f4e7dc1330c42998833ca4f03cc3b392021-12-02T17:31:30ZETS transcription factors induce a unique UV damage signature that drives recurrent mutagenesis in melanoma10.1038/s41467-018-05064-02041-1723https://doaj.org/article/1f4e7dc1330c42998833ca4f03cc3b392018-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05064-0https://doaj.org/toc/2041-1723Many factors contribute to mutation hotspots in cancer cells. Here the authors map UV damage at single-nucleotide resolution across the human genome and find that binding sites of ETS transcription factors are especially prone to forming UV lesions, leading to mutation hotspots in melanoma.Peng MaoAlexander J. BrownShingo EsakiSvetlana LockwoodGregory M. K. PoonMichael J. SmerdonSteven A. RobertsJohn J. WyrickNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Peng Mao Alexander J. Brown Shingo Esaki Svetlana Lockwood Gregory M. K. Poon Michael J. Smerdon Steven A. Roberts John J. Wyrick ETS transcription factors induce a unique UV damage signature that drives recurrent mutagenesis in melanoma
description	Many factors contribute to mutation hotspots in cancer cells. Here the authors map UV damage at single-nucleotide resolution across the human genome and find that binding sites of ETS transcription factors are especially prone to forming UV lesions, leading to mutation hotspots in melanoma.
format	article
author	Peng Mao Alexander J. Brown Shingo Esaki Svetlana Lockwood Gregory M. K. Poon Michael J. Smerdon Steven A. Roberts John J. Wyrick
author_facet	Peng Mao Alexander J. Brown Shingo Esaki Svetlana Lockwood Gregory M. K. Poon Michael J. Smerdon Steven A. Roberts John J. Wyrick
author_sort	Peng Mao
title	ETS transcription factors induce a unique UV damage signature that drives recurrent mutagenesis in melanoma
title_short	ETS transcription factors induce a unique UV damage signature that drives recurrent mutagenesis in melanoma
title_full	ETS transcription factors induce a unique UV damage signature that drives recurrent mutagenesis in melanoma
title_fullStr	ETS transcription factors induce a unique UV damage signature that drives recurrent mutagenesis in melanoma
title_full_unstemmed	ETS transcription factors induce a unique UV damage signature that drives recurrent mutagenesis in melanoma
title_sort	ets transcription factors induce a unique uv damage signature that drives recurrent mutagenesis in melanoma
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/1f4e7dc1330c42998833ca4f03cc3b39
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ETS transcription factors induce a unique UV damage signature that drives recurrent mutagenesis in melanoma

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