Induced p53 loss in mouse luminal cells causes clonal expansion and development of mammary tumours

Several breast cancers may originate from mammary luminal cells and inactivating mutations of p53 are present in most triple-negative breast cancers. Here, the authors show that loss of p53 from luminal cells in mice results in their clonal expansion and mammary tumour formation.

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Autores principales:	Luwei Tao, Dongxi Xiang, Ying Xie, Roderick T. Bronson, Zhe Li
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1f5356261f8642e39f9eb48de118f875
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spelling	oai:doaj.org-article:1f5356261f8642e39f9eb48de118f8752021-12-02T14:40:58ZInduced p53 loss in mouse luminal cells causes clonal expansion and development of mammary tumours10.1038/ncomms144312041-1723https://doaj.org/article/1f5356261f8642e39f9eb48de118f8752017-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms14431https://doaj.org/toc/2041-1723Several breast cancers may originate from mammary luminal cells and inactivating mutations of p53 are present in most triple-negative breast cancers. Here, the authors show that loss of p53 from luminal cells in mice results in their clonal expansion and mammary tumour formation.Luwei TaoDongxi XiangYing XieRoderick T. BronsonZhe LiNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Luwei Tao Dongxi Xiang Ying Xie Roderick T. Bronson Zhe Li Induced p53 loss in mouse luminal cells causes clonal expansion and development of mammary tumours
description	Several breast cancers may originate from mammary luminal cells and inactivating mutations of p53 are present in most triple-negative breast cancers. Here, the authors show that loss of p53 from luminal cells in mice results in their clonal expansion and mammary tumour formation.
format	article
author	Luwei Tao Dongxi Xiang Ying Xie Roderick T. Bronson Zhe Li
author_facet	Luwei Tao Dongxi Xiang Ying Xie Roderick T. Bronson Zhe Li
author_sort	Luwei Tao
title	Induced p53 loss in mouse luminal cells causes clonal expansion and development of mammary tumours
title_short	Induced p53 loss in mouse luminal cells causes clonal expansion and development of mammary tumours
title_full	Induced p53 loss in mouse luminal cells causes clonal expansion and development of mammary tumours
title_fullStr	Induced p53 loss in mouse luminal cells causes clonal expansion and development of mammary tumours
title_full_unstemmed	Induced p53 loss in mouse luminal cells causes clonal expansion and development of mammary tumours
title_sort	induced p53 loss in mouse luminal cells causes clonal expansion and development of mammary tumours
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/1f5356261f8642e39f9eb48de118f875
work_keys_str_mv	AT luweitao inducedp53lossinmouseluminalcellscausesclonalexpansionanddevelopmentofmammarytumours AT dongxixiang inducedp53lossinmouseluminalcellscausesclonalexpansionanddevelopmentofmammarytumours AT yingxie inducedp53lossinmouseluminalcellscausesclonalexpansionanddevelopmentofmammarytumours AT rodericktbronson inducedp53lossinmouseluminalcellscausesclonalexpansionanddevelopmentofmammarytumours AT zheli inducedp53lossinmouseluminalcellscausesclonalexpansionanddevelopmentofmammarytumours
_version_	1718390039732289536

Induced p53 loss in mouse luminal cells causes clonal expansion and development of mammary tumours

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