Studying the effect of particle size and coating type on the blood kinetics of superparamagnetic iron oxide nanoparticles

Farnoosh Roohi, Jessica Lohrke, Andreas Ide, Gunnar Sch&uuml;tz, Katrin DasslerMR and CT Contrast Media Research, Bayer Pharma AG, Berlin, GermanyPurpose: Magnetic resonance imaging (MRI), one of the most powerful imaging techniques available, usually requires the use of an on-demand designe...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Roohi F, Lohrke J, Ide A, Schuetz G, Dassler K
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2012
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/1f54a9ac73654a37a7c201138f629375
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:1f54a9ac73654a37a7c201138f629375
record_format	dspace
spelling	oai:doaj.org-article:1f54a9ac73654a37a7c201138f6293752021-12-02T00:54:54ZStudying the effect of particle size and coating type on the blood kinetics of superparamagnetic iron oxide nanoparticles1176-91141178-2013https://doaj.org/article/1f54a9ac73654a37a7c201138f6293752012-08-01T00:00:00Zhttp://www.dovepress.com/studying-the-effect-of-particle-size-and-coating-type-on-the-blood-kin-a10657https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Farnoosh Roohi, Jessica Lohrke, Andreas Ide, Gunnar Sch&uuml;tz, Katrin DasslerMR and CT Contrast Media Research, Bayer Pharma AG, Berlin, GermanyPurpose: Magnetic resonance imaging (MRI), one of the most powerful imaging techniques available, usually requires the use of an on-demand designed contrast agent to fully exploit its potential. The blood kinetics of the contrast agent represent an important factor that needs to be considered depending on the objective of the medical examination. For particulate contrast agents, such as superparamagnetic iron oxide nanoparticles (SPIOs), the key parameters are particle size and characteristics of the coating material. In this study we analyzed the effect of these two properties independently and systematically on the magnetic behavior and blood half-life of SPIOs.Methods: Eleven different SPIOs were synthesized for this study. In the first set (a), seven carboxydextran (CDX)-coated SPIOs of different sizes (19&ndash;86 nm) were obtained by fractionating a broadly size-distributed CDX&ndash;SPIO. The second set (b) contained three SPIOs of identical size (50 nm) that were stabilized with different coating materials, polyacrylic acid (PAA), polyethylene glycol, and starch. Furthermore, small PAA&ndash;SPIOs (20 nm) were synthesized to gain a global insight into the effects of particle size vs coating characteristics. Saturation magnetization and proton relaxivity were determined to represent the magnetic and imaging properties. The blood half-life was analyzed in rats using MRI, time-domain nuclear magnetic resonance, and inductively coupled plasma optical emission spectrometry.Results: By changing the particle size without modifying any other parameters, the relaxivity r2 increased with increasing mean particle diameter. However, the blood half-life was shorter for larger particles. The effect of the coating material on magnetic properties was less pronounced, but it had a strong influence on blood kinetics depending on the ionic character of the coating material.Conclusion: In this report we systematically demonstrated that both particle size and coating material influence blood kinetics and magnetic properties of SPIO independently. These data provide key information for the selection of a contrast agent for a defined application and are additionally valuable for other nano areas, such as hyperthermia, drug delivery, and nanotoxicology.Keywords: SPIO, relaxivity, blood half-life, MRIRoohi FLohrke JIde ASchuetz GDassler KDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2012, Iss default, Pp 4447-4458 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Roohi F Lohrke J Ide A Schuetz G Dassler K Studying the effect of particle size and coating type on the blood kinetics of superparamagnetic iron oxide nanoparticles
description	Farnoosh Roohi, Jessica Lohrke, Andreas Ide, Gunnar Sch&uuml;tz, Katrin DasslerMR and CT Contrast Media Research, Bayer Pharma AG, Berlin, GermanyPurpose: Magnetic resonance imaging (MRI), one of the most powerful imaging techniques available, usually requires the use of an on-demand designed contrast agent to fully exploit its potential. The blood kinetics of the contrast agent represent an important factor that needs to be considered depending on the objective of the medical examination. For particulate contrast agents, such as superparamagnetic iron oxide nanoparticles (SPIOs), the key parameters are particle size and characteristics of the coating material. In this study we analyzed the effect of these two properties independently and systematically on the magnetic behavior and blood half-life of SPIOs.Methods: Eleven different SPIOs were synthesized for this study. In the first set (a), seven carboxydextran (CDX)-coated SPIOs of different sizes (19&ndash;86 nm) were obtained by fractionating a broadly size-distributed CDX&ndash;SPIO. The second set (b) contained three SPIOs of identical size (50 nm) that were stabilized with different coating materials, polyacrylic acid (PAA), polyethylene glycol, and starch. Furthermore, small PAA&ndash;SPIOs (20 nm) were synthesized to gain a global insight into the effects of particle size vs coating characteristics. Saturation magnetization and proton relaxivity were determined to represent the magnetic and imaging properties. The blood half-life was analyzed in rats using MRI, time-domain nuclear magnetic resonance, and inductively coupled plasma optical emission spectrometry.Results: By changing the particle size without modifying any other parameters, the relaxivity r2 increased with increasing mean particle diameter. However, the blood half-life was shorter for larger particles. The effect of the coating material on magnetic properties was less pronounced, but it had a strong influence on blood kinetics depending on the ionic character of the coating material.Conclusion: In this report we systematically demonstrated that both particle size and coating material influence blood kinetics and magnetic properties of SPIO independently. These data provide key information for the selection of a contrast agent for a defined application and are additionally valuable for other nano areas, such as hyperthermia, drug delivery, and nanotoxicology.Keywords: SPIO, relaxivity, blood half-life, MRI
format	article
author	Roohi F Lohrke J Ide A Schuetz G Dassler K
author_facet	Roohi F Lohrke J Ide A Schuetz G Dassler K
author_sort	Roohi F
title	Studying the effect of particle size and coating type on the blood kinetics of superparamagnetic iron oxide nanoparticles
title_short	Studying the effect of particle size and coating type on the blood kinetics of superparamagnetic iron oxide nanoparticles
title_full	Studying the effect of particle size and coating type on the blood kinetics of superparamagnetic iron oxide nanoparticles
title_fullStr	Studying the effect of particle size and coating type on the blood kinetics of superparamagnetic iron oxide nanoparticles
title_full_unstemmed	Studying the effect of particle size and coating type on the blood kinetics of superparamagnetic iron oxide nanoparticles
title_sort	studying the effect of particle size and coating type on the blood kinetics of superparamagnetic iron oxide nanoparticles
publisher	Dove Medical Press
publishDate	2012
url	https://doaj.org/article/1f54a9ac73654a37a7c201138f629375
work_keys_str_mv	AT roohif studyingtheeffectofparticlesizeandcoatingtypeonthebloodkineticsofsuperparamagneticironoxidenanoparticles AT lohrkej studyingtheeffectofparticlesizeandcoatingtypeonthebloodkineticsofsuperparamagneticironoxidenanoparticles AT idea studyingtheeffectofparticlesizeandcoatingtypeonthebloodkineticsofsuperparamagneticironoxidenanoparticles AT schuetzg studyingtheeffectofparticlesizeandcoatingtypeonthebloodkineticsofsuperparamagneticironoxidenanoparticles AT dasslerk studyingtheeffectofparticlesizeandcoatingtypeonthebloodkineticsofsuperparamagneticironoxidenanoparticles
_version_	1718403370069262336

Studying the effect of particle size and coating type on the blood kinetics of superparamagnetic iron oxide nanoparticles

Ejemplares similares