Host Immune Response Triggered by Graphene Quantum-Dot-Mediated Photodynamic Therapy for Oral Squamous Cell Carcinoma

Xiliu Zhang,1 Hongyu Li,1,* Chen Yi,1,* Guosheng Chen,2 Ye Li,1 Ying Zhou,1 Guanhui Chen,1 Yiming Li,1 Yi He,1 Dongsheng Yu1 1Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Stomatology, Guangzhou 510055, People’s Repu...

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Autores principales:	Zhang X, Li H, Yi C, Chen G, Li Y, Zhou Y, He Y, Yu D
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	graphene quantum dots photodynamic therapy host immunity oral squamous cell carcinoma Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/1f5a0864f3db47afb19c8e99e4277474
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spelling	oai:doaj.org-article:1f5a0864f3db47afb19c8e99e42774742021-12-02T14:58:12ZHost Immune Response Triggered by Graphene Quantum-Dot-Mediated Photodynamic Therapy for Oral Squamous Cell Carcinoma1178-2013https://doaj.org/article/1f5a0864f3db47afb19c8e99e42774742020-12-01T00:00:00Zhttps://www.dovepress.com/host-immune-response-triggered-by-graphene-quantum-dot-mediated-photod-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Xiliu Zhang,1 Hongyu Li,1,* Chen Yi,1,* Guosheng Chen,2 Ye Li,1 Ying Zhou,1 Guanhui Chen,1 Yiming Li,1 Yi He,1 Dongsheng Yu1 1Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Stomatology, Guangzhou 510055, People’s Republic of China; 2MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, People’s Republic of China*These authors contributed equally to this workCorrespondence: Dongsheng YuGuanghua School of Stomatology, Hospital of Stomatology, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Stomatology, Guangzhou 510055, People’s Republic of ChinaEmail yudsh@mail.sysu.edu.cnIntroduction: With the innovation of photosensitizers, photodynamic therapy is now widely used in antitumor detection and treatment. Graphene quantum dots (GQDs) are proposed as a promising alternative photosensitizer due to their high biocompatibility, specific photoactivity, and strong tumor concentration. However, the changes in host immunity triggered by GQDs have only rarely been reported.Methods: In this work, GQDs as photosensitizers were conjugated to polyethylene glycol (PEG) to enhance solubility and blood circulation. The phototoxicity of the resulting GQD-PEG nanomaterials was then detected in vitro and in vivo. The antitumor immunity triggered by GQD-PEG under irradiation was further evaluated in an oral squamous cell carcinoma animal model.Results: The obtained GQD-PEG nanomaterials exhibited low cytotoxicity, good solution stability, and excellent endocytosis. Both in vitro and in vivo, all demonstrated strong ablation for oral squamous cell carcinoma under irradiation. Meanwhile, host-immunity-related CD8+ T cells (cytotoxic T lymphocytes) and proinflammatory cytokines, including IFN-γ and TNF-α, were significantly increased after photo-activated antitumor activity.Conclusion: These results highlight the dominant role of GQD-PEG in photodynamic therapy and could have significant implications for further combination therapy as a promising antitumor immune response strategy triggered by nanomaterials.Keywords: graphene quantum dots, photodynamic therapy, host immunity, oral squamous cell carcinomaZhang XLi HYi CChen GLi YZhou YChen GLi YHe YYu DDove Medical Pressarticlegraphene quantum dotsphotodynamic therapyhost immunityoral squamous cell carcinomaMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 15, Pp 9627-9638 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	graphene quantum dots photodynamic therapy host immunity oral squamous cell carcinoma Medicine (General) R5-920
spellingShingle	graphene quantum dots photodynamic therapy host immunity oral squamous cell carcinoma Medicine (General) R5-920 Zhang X Li H Yi C Chen G Li Y Zhou Y Chen G Li Y He Y Yu D Host Immune Response Triggered by Graphene Quantum-Dot-Mediated Photodynamic Therapy for Oral Squamous Cell Carcinoma
description	Xiliu Zhang,1 Hongyu Li,1,* Chen Yi,1,* Guosheng Chen,2 Ye Li,1 Ying Zhou,1 Guanhui Chen,1 Yiming Li,1 Yi He,1 Dongsheng Yu1 1Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Stomatology, Guangzhou 510055, People’s Republic of China; 2MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, People’s Republic of China*These authors contributed equally to this workCorrespondence: Dongsheng YuGuanghua School of Stomatology, Hospital of Stomatology, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Stomatology, Guangzhou 510055, People’s Republic of ChinaEmail yudsh@mail.sysu.edu.cnIntroduction: With the innovation of photosensitizers, photodynamic therapy is now widely used in antitumor detection and treatment. Graphene quantum dots (GQDs) are proposed as a promising alternative photosensitizer due to their high biocompatibility, specific photoactivity, and strong tumor concentration. However, the changes in host immunity triggered by GQDs have only rarely been reported.Methods: In this work, GQDs as photosensitizers were conjugated to polyethylene glycol (PEG) to enhance solubility and blood circulation. The phototoxicity of the resulting GQD-PEG nanomaterials was then detected in vitro and in vivo. The antitumor immunity triggered by GQD-PEG under irradiation was further evaluated in an oral squamous cell carcinoma animal model.Results: The obtained GQD-PEG nanomaterials exhibited low cytotoxicity, good solution stability, and excellent endocytosis. Both in vitro and in vivo, all demonstrated strong ablation for oral squamous cell carcinoma under irradiation. Meanwhile, host-immunity-related CD8+ T cells (cytotoxic T lymphocytes) and proinflammatory cytokines, including IFN-γ and TNF-α, were significantly increased after photo-activated antitumor activity.Conclusion: These results highlight the dominant role of GQD-PEG in photodynamic therapy and could have significant implications for further combination therapy as a promising antitumor immune response strategy triggered by nanomaterials.Keywords: graphene quantum dots, photodynamic therapy, host immunity, oral squamous cell carcinoma
format	article
author	Zhang X Li H Yi C Chen G Li Y Zhou Y Chen G Li Y He Y Yu D
author_facet	Zhang X Li H Yi C Chen G Li Y Zhou Y Chen G Li Y He Y Yu D
author_sort	Zhang X
title	Host Immune Response Triggered by Graphene Quantum-Dot-Mediated Photodynamic Therapy for Oral Squamous Cell Carcinoma
title_short	Host Immune Response Triggered by Graphene Quantum-Dot-Mediated Photodynamic Therapy for Oral Squamous Cell Carcinoma
title_full	Host Immune Response Triggered by Graphene Quantum-Dot-Mediated Photodynamic Therapy for Oral Squamous Cell Carcinoma
title_fullStr	Host Immune Response Triggered by Graphene Quantum-Dot-Mediated Photodynamic Therapy for Oral Squamous Cell Carcinoma
title_full_unstemmed	Host Immune Response Triggered by Graphene Quantum-Dot-Mediated Photodynamic Therapy for Oral Squamous Cell Carcinoma
title_sort	host immune response triggered by graphene quantum-dot-mediated photodynamic therapy for oral squamous cell carcinoma
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/1f5a0864f3db47afb19c8e99e4277474
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Host Immune Response Triggered by Graphene Quantum-Dot-Mediated Photodynamic Therapy for Oral Squamous Cell Carcinoma

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