Entangled radicals may explain lithium effects on hyperactivity
Abstract It is known that bipolar disorder and its lithium treatment involve the modulation of oxidative stress. Moreover, it has been observed that lithium’s effects are isotope-dependent. Based on these findings, here we propose that lithium exerts its effects by influencing the recombination dyna...
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Nature Portfolio
2021
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oai:doaj.org-article:1f5a37f7c7a74e61b0f614893b6b26122021-12-02T17:34:31ZEntangled radicals may explain lithium effects on hyperactivity10.1038/s41598-021-91388-92045-2322https://doaj.org/article/1f5a37f7c7a74e61b0f614893b6b26122021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-91388-9https://doaj.org/toc/2045-2322Abstract It is known that bipolar disorder and its lithium treatment involve the modulation of oxidative stress. Moreover, it has been observed that lithium’s effects are isotope-dependent. Based on these findings, here we propose that lithium exerts its effects by influencing the recombination dynamics of a naturally occurring radical pair involving oxygen. We develop a simple model inspired by the radical-pair mechanism in cryptochrome in the context of avian magnetoreception and xenon-induced anesthesia. Our model reproduces the observed isotopic dependence in the lithium treatment of hyperactivity in rats. It predicts a magnetic-field dependence of the effectiveness of lithium, which provides one potential experimental test of our hypothesis. Our findings show that Nature might harness quantum entanglement for the brain’s cognitive processes.Hadi Zadeh-HaghighiChristoph SimonNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021) |
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Medicine R Science Q Hadi Zadeh-Haghighi Christoph Simon Entangled radicals may explain lithium effects on hyperactivity |
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Abstract It is known that bipolar disorder and its lithium treatment involve the modulation of oxidative stress. Moreover, it has been observed that lithium’s effects are isotope-dependent. Based on these findings, here we propose that lithium exerts its effects by influencing the recombination dynamics of a naturally occurring radical pair involving oxygen. We develop a simple model inspired by the radical-pair mechanism in cryptochrome in the context of avian magnetoreception and xenon-induced anesthesia. Our model reproduces the observed isotopic dependence in the lithium treatment of hyperactivity in rats. It predicts a magnetic-field dependence of the effectiveness of lithium, which provides one potential experimental test of our hypothesis. Our findings show that Nature might harness quantum entanglement for the brain’s cognitive processes. |
format |
article |
author |
Hadi Zadeh-Haghighi Christoph Simon |
author_facet |
Hadi Zadeh-Haghighi Christoph Simon |
author_sort |
Hadi Zadeh-Haghighi |
title |
Entangled radicals may explain lithium effects on hyperactivity |
title_short |
Entangled radicals may explain lithium effects on hyperactivity |
title_full |
Entangled radicals may explain lithium effects on hyperactivity |
title_fullStr |
Entangled radicals may explain lithium effects on hyperactivity |
title_full_unstemmed |
Entangled radicals may explain lithium effects on hyperactivity |
title_sort |
entangled radicals may explain lithium effects on hyperactivity |
publisher |
Nature Portfolio |
publishDate |
2021 |
url |
https://doaj.org/article/1f5a37f7c7a74e61b0f614893b6b2612 |
work_keys_str_mv |
AT hadizadehhaghighi entangledradicalsmayexplainlithiumeffectsonhyperactivity AT christophsimon entangledradicalsmayexplainlithiumeffectsonhyperactivity |
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1718379926816555008 |