Entangled radicals may explain lithium effects on hyperactivity

Abstract It is known that bipolar disorder and its lithium treatment involve the modulation of oxidative stress. Moreover, it has been observed that lithium’s effects are isotope-dependent. Based on these findings, here we propose that lithium exerts its effects by influencing the recombination dyna...

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Autores principales:	Hadi Zadeh-Haghighi, Christoph Simon
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1f5a37f7c7a74e61b0f614893b6b2612
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spelling	oai:doaj.org-article:1f5a37f7c7a74e61b0f614893b6b26122021-12-02T17:34:31ZEntangled radicals may explain lithium effects on hyperactivity10.1038/s41598-021-91388-92045-2322https://doaj.org/article/1f5a37f7c7a74e61b0f614893b6b26122021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-91388-9https://doaj.org/toc/2045-2322Abstract It is known that bipolar disorder and its lithium treatment involve the modulation of oxidative stress. Moreover, it has been observed that lithium’s effects are isotope-dependent. Based on these findings, here we propose that lithium exerts its effects by influencing the recombination dynamics of a naturally occurring radical pair involving oxygen. We develop a simple model inspired by the radical-pair mechanism in cryptochrome in the context of avian magnetoreception and xenon-induced anesthesia. Our model reproduces the observed isotopic dependence in the lithium treatment of hyperactivity in rats. It predicts a magnetic-field dependence of the effectiveness of lithium, which provides one potential experimental test of our hypothesis. Our findings show that Nature might harness quantum entanglement for the brain’s cognitive processes.Hadi Zadeh-HaghighiChristoph SimonNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hadi Zadeh-Haghighi Christoph Simon Entangled radicals may explain lithium effects on hyperactivity
description	Abstract It is known that bipolar disorder and its lithium treatment involve the modulation of oxidative stress. Moreover, it has been observed that lithium’s effects are isotope-dependent. Based on these findings, here we propose that lithium exerts its effects by influencing the recombination dynamics of a naturally occurring radical pair involving oxygen. We develop a simple model inspired by the radical-pair mechanism in cryptochrome in the context of avian magnetoreception and xenon-induced anesthesia. Our model reproduces the observed isotopic dependence in the lithium treatment of hyperactivity in rats. It predicts a magnetic-field dependence of the effectiveness of lithium, which provides one potential experimental test of our hypothesis. Our findings show that Nature might harness quantum entanglement for the brain’s cognitive processes.
format	article
author	Hadi Zadeh-Haghighi Christoph Simon
author_facet	Hadi Zadeh-Haghighi Christoph Simon
author_sort	Hadi Zadeh-Haghighi
title	Entangled radicals may explain lithium effects on hyperactivity
title_short	Entangled radicals may explain lithium effects on hyperactivity
title_full	Entangled radicals may explain lithium effects on hyperactivity
title_fullStr	Entangled radicals may explain lithium effects on hyperactivity
title_full_unstemmed	Entangled radicals may explain lithium effects on hyperactivity
title_sort	entangled radicals may explain lithium effects on hyperactivity
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/1f5a37f7c7a74e61b0f614893b6b2612
work_keys_str_mv	AT hadizadehhaghighi entangledradicalsmayexplainlithiumeffectsonhyperactivity AT christophsimon entangledradicalsmayexplainlithiumeffectsonhyperactivity
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Entangled radicals may explain lithium effects on hyperactivity

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