Amino acid deprivation induces AKT activation by inducing GCN2/ATF4/REDD1 axis
Abstract Amino acid availability is sensed by various signaling molecules, including general control nonderepressible 2 (GCN2) and mechanistic target of rapamycin complex 1 (mTORC1). However, it is unclear how these sensors are associated with cancer cell survival under low amino acid availability....
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| Main Authors: | , , , , |
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| Format: | article |
| Language: | EN |
| Published: |
Nature Publishing Group
2021
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| Subjects: | |
| Online Access: | https://doaj.org/article/1f5af1fef3a44d8a8f236de5a2388f04 |
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