White matter changes and word finding failures with increasing age.

<h4>Background</h4>Increasing life expectancy necessitates the better understanding of the neurophysiological underpinnings of age-related cognitive changes. The majority of research examining structural-cognitive relationships in aging focuses on the role of age-related changes to grey...

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Autores principales:	Emmanuel A Stamatakis, Meredith A Shafto, Guy Williams, Phyllis Tam, Lorraine K Tyler
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1f5c5032c4714811b701164df8211c41
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id	oai:doaj.org-article:1f5c5032c4714811b701164df8211c41
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spelling	oai:doaj.org-article:1f5c5032c4714811b701164df8211c412021-11-18T07:00:40ZWhite matter changes and word finding failures with increasing age.1932-620310.1371/journal.pone.0014496https://doaj.org/article/1f5c5032c4714811b701164df8211c412011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21249127/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Increasing life expectancy necessitates the better understanding of the neurophysiological underpinnings of age-related cognitive changes. The majority of research examining structural-cognitive relationships in aging focuses on the role of age-related changes to grey matter integrity. In the current study, we examined the relationship between age-related changes in white matter and language production. More specifically, we concentrated on word-finding failures, which increase with age.<h4>Methodology/principal findings</h4>We used Diffusion tensor MRI (a technique used to image, in vivo, the diffusion of water molecules in brain tissue) to relate white matter integrity to measures of successful and unsuccessful picture naming. Diffusion tensor images were used to calculate Fractional Anisotropy (FA) images. FA is considered to be a measure of white matter organization/integrity. FA images were related to measures of successful picture naming and to word finding failures using voxel-based linear regression analyses. Successful naming rates correlated positively with white matter integrity across a broad range of regions implicated in language production. However, word finding failure rates correlated negatively with a more restricted region in the posterior aspect of superior longitudinal fasciculus.<h4>Conclusions/significance</h4>The use of DTI-MRI provides evidence for the relationship between age-related white matter changes in specific language regions and word finding failures in old age.Emmanuel A StamatakisMeredith A ShaftoGuy WilliamsPhyllis TamLorraine K TylerPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 1, p e14496 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Emmanuel A Stamatakis Meredith A Shafto Guy Williams Phyllis Tam Lorraine K Tyler White matter changes and word finding failures with increasing age.
description	<h4>Background</h4>Increasing life expectancy necessitates the better understanding of the neurophysiological underpinnings of age-related cognitive changes. The majority of research examining structural-cognitive relationships in aging focuses on the role of age-related changes to grey matter integrity. In the current study, we examined the relationship between age-related changes in white matter and language production. More specifically, we concentrated on word-finding failures, which increase with age.<h4>Methodology/principal findings</h4>We used Diffusion tensor MRI (a technique used to image, in vivo, the diffusion of water molecules in brain tissue) to relate white matter integrity to measures of successful and unsuccessful picture naming. Diffusion tensor images were used to calculate Fractional Anisotropy (FA) images. FA is considered to be a measure of white matter organization/integrity. FA images were related to measures of successful picture naming and to word finding failures using voxel-based linear regression analyses. Successful naming rates correlated positively with white matter integrity across a broad range of regions implicated in language production. However, word finding failure rates correlated negatively with a more restricted region in the posterior aspect of superior longitudinal fasciculus.<h4>Conclusions/significance</h4>The use of DTI-MRI provides evidence for the relationship between age-related white matter changes in specific language regions and word finding failures in old age.
format	article
author	Emmanuel A Stamatakis Meredith A Shafto Guy Williams Phyllis Tam Lorraine K Tyler
author_facet	Emmanuel A Stamatakis Meredith A Shafto Guy Williams Phyllis Tam Lorraine K Tyler
author_sort	Emmanuel A Stamatakis
title	White matter changes and word finding failures with increasing age.
title_short	White matter changes and word finding failures with increasing age.
title_full	White matter changes and word finding failures with increasing age.
title_fullStr	White matter changes and word finding failures with increasing age.
title_full_unstemmed	White matter changes and word finding failures with increasing age.
title_sort	white matter changes and word finding failures with increasing age.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/1f5c5032c4714811b701164df8211c41
work_keys_str_mv	AT emmanuelastamatakis whitematterchangesandwordfindingfailureswithincreasingage AT meredithashafto whitematterchangesandwordfindingfailureswithincreasingage AT guywilliams whitematterchangesandwordfindingfailureswithincreasingage AT phyllistam whitematterchangesandwordfindingfailureswithincreasingage AT lorrainektyler whitematterchangesandwordfindingfailureswithincreasingage
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White matter changes and word finding failures with increasing age.

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