N-Methyl-d-aspartate (NMDA) receptor antibody in relation to autism spectrum disorder (ASD): presence and association with symptom profile

Abstract Background Several studies pointed to immune dysregulation abnormalities linked to autism spectrum disorders (ASD). Of those, several autoantibodies had been identified. Recent findings of N-methyl d-aspartate (NMDA) antibodies in autoimmune encephalitis suggested that it caused symptoms li...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Heba Hamed Elshahawi, Ghada Refaat Amin Taha, Hanan Mohamed Ezzeldin Azzam, Reem H. El Ghamry, Ahmed Adel Mohammad Abdelgawad, Mohammad Abdullah Ahmad Abdullah Elshiekh
Formato:	article
Lenguaje:	EN
Publicado:	SpringerOpen 2021
Materias:	Autism Autoimmune Autoantibodies NMDA receptor Psychiatry RC435-571
Acceso en línea:	https://doaj.org/article/1f5c8db2ad8749a0a0df1a79298ecae4
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:1f5c8db2ad8749a0a0df1a79298ecae4
record_format	dspace
spelling	oai:doaj.org-article:1f5c8db2ad8749a0a0df1a79298ecae42021-11-07T12:08:51ZN-Methyl-d-aspartate (NMDA) receptor antibody in relation to autism spectrum disorder (ASD): presence and association with symptom profile10.1186/s43045-021-00141-52090-5416https://doaj.org/article/1f5c8db2ad8749a0a0df1a79298ecae42021-11-01T00:00:00Zhttps://doi.org/10.1186/s43045-021-00141-5https://doaj.org/toc/2090-5416Abstract Background Several studies pointed to immune dysregulation abnormalities linked to autism spectrum disorders (ASD). Of those, several autoantibodies had been identified. Recent findings of N-methyl d-aspartate (NMDA) antibodies in autoimmune encephalitis suggested that it caused symptoms like autistic regression. Thus, the purpose of the study was to test for the presence of anti-NMDAR antibodies in the ASD disorder population and to correlate this with the clinical findings. Results Eighty-seven autistic children, 4–12 years old, were enrolled in the study and were matched with sixty typically developing children used as controls. The diagnosis of cases was confirmed by ADOS-2 and clinical evaluation. None of the control children had positive anti-NMDAR antibodies, while 26.4% (23 children) of the patients’ group were positive for serum anti-NMDA receptor antibodies (> 200 pg/ml, p = 0.0157). The positive anti-NMDAR antibody was statistically correlated with better speech stage (p = 0.017), more severe stereotyped behavior (p ≤ 0.001), and abnormal EEG findings (p = 0.025). Conclusions There is a possibility of the presence of anti-NMDAR antibodies in the autism spectrum disorder population with certain characteristics, especially the severity of the stereotyped behaviors.Heba Hamed ElshahawiGhada Refaat Amin TahaHanan Mohamed Ezzeldin AzzamReem H. El GhamryAhmed Adel Mohammad AbdelgawadMohammad Abdullah Ahmad Abdullah ElshiekhSpringerOpenarticleAutismAutoimmuneAutoantibodiesNMDA receptorPsychiatryRC435-571ENMiddle East Current Psychiatry, Vol 28, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Autism Autoimmune Autoantibodies NMDA receptor Psychiatry RC435-571
spellingShingle	Autism Autoimmune Autoantibodies NMDA receptor Psychiatry RC435-571 Heba Hamed Elshahawi Ghada Refaat Amin Taha Hanan Mohamed Ezzeldin Azzam Reem H. El Ghamry Ahmed Adel Mohammad Abdelgawad Mohammad Abdullah Ahmad Abdullah Elshiekh N-Methyl-d-aspartate (NMDA) receptor antibody in relation to autism spectrum disorder (ASD): presence and association with symptom profile
description	Abstract Background Several studies pointed to immune dysregulation abnormalities linked to autism spectrum disorders (ASD). Of those, several autoantibodies had been identified. Recent findings of N-methyl d-aspartate (NMDA) antibodies in autoimmune encephalitis suggested that it caused symptoms like autistic regression. Thus, the purpose of the study was to test for the presence of anti-NMDAR antibodies in the ASD disorder population and to correlate this with the clinical findings. Results Eighty-seven autistic children, 4–12 years old, were enrolled in the study and were matched with sixty typically developing children used as controls. The diagnosis of cases was confirmed by ADOS-2 and clinical evaluation. None of the control children had positive anti-NMDAR antibodies, while 26.4% (23 children) of the patients’ group were positive for serum anti-NMDA receptor antibodies (> 200 pg/ml, p = 0.0157). The positive anti-NMDAR antibody was statistically correlated with better speech stage (p = 0.017), more severe stereotyped behavior (p ≤ 0.001), and abnormal EEG findings (p = 0.025). Conclusions There is a possibility of the presence of anti-NMDAR antibodies in the autism spectrum disorder population with certain characteristics, especially the severity of the stereotyped behaviors.
format	article
author	Heba Hamed Elshahawi Ghada Refaat Amin Taha Hanan Mohamed Ezzeldin Azzam Reem H. El Ghamry Ahmed Adel Mohammad Abdelgawad Mohammad Abdullah Ahmad Abdullah Elshiekh
author_facet	Heba Hamed Elshahawi Ghada Refaat Amin Taha Hanan Mohamed Ezzeldin Azzam Reem H. El Ghamry Ahmed Adel Mohammad Abdelgawad Mohammad Abdullah Ahmad Abdullah Elshiekh
author_sort	Heba Hamed Elshahawi
title	N-Methyl-d-aspartate (NMDA) receptor antibody in relation to autism spectrum disorder (ASD): presence and association with symptom profile
title_short	N-Methyl-d-aspartate (NMDA) receptor antibody in relation to autism spectrum disorder (ASD): presence and association with symptom profile
title_full	N-Methyl-d-aspartate (NMDA) receptor antibody in relation to autism spectrum disorder (ASD): presence and association with symptom profile
title_fullStr	N-Methyl-d-aspartate (NMDA) receptor antibody in relation to autism spectrum disorder (ASD): presence and association with symptom profile
title_full_unstemmed	N-Methyl-d-aspartate (NMDA) receptor antibody in relation to autism spectrum disorder (ASD): presence and association with symptom profile
title_sort	n-methyl-d-aspartate (nmda) receptor antibody in relation to autism spectrum disorder (asd): presence and association with symptom profile
publisher	SpringerOpen
publishDate	2021
url	https://doaj.org/article/1f5c8db2ad8749a0a0df1a79298ecae4
work_keys_str_mv	AT hebahamedelshahawi nmethyldaspartatenmdareceptorantibodyinrelationtoautismspectrumdisorderasdpresenceandassociationwithsymptomprofile AT ghadarefaatamintaha nmethyldaspartatenmdareceptorantibodyinrelationtoautismspectrumdisorderasdpresenceandassociationwithsymptomprofile AT hananmohamedezzeldinazzam nmethyldaspartatenmdareceptorantibodyinrelationtoautismspectrumdisorderasdpresenceandassociationwithsymptomprofile AT reemhelghamry nmethyldaspartatenmdareceptorantibodyinrelationtoautismspectrumdisorderasdpresenceandassociationwithsymptomprofile AT ahmedadelmohammadabdelgawad nmethyldaspartatenmdareceptorantibodyinrelationtoautismspectrumdisorderasdpresenceandassociationwithsymptomprofile AT mohammadabdullahahmadabdullahelshiekh nmethyldaspartatenmdareceptorantibodyinrelationtoautismspectrumdisorderasdpresenceandassociationwithsymptomprofile
_version_	1718443534356316160

N-Methyl-d-aspartate (NMDA) receptor antibody in relation to autism spectrum disorder (ASD): presence and association with symptom profile

Ejemplares similares