Imaging features and differences among the three primary malignant non-Wilms tumors in children

Abstract Background The pathology, treatment and prognosis of malignant non-Wilms tumors (NWTs) are different, so it is necessary to differentiate these types of tumors. The purpose of this study was to review the clinical and imaging features of malignant NWTs and features of tumor metastasis. Meth...

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Autores principales:	Yupeng Zhu, Wangxing Fu, Yangyue Huang, Ning Sun, Yun Peng
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Children Renal tumor Clear cell sarcoma of kidney Malignant rhabdomyoma tumor of kidney Renal cell carcinoma Imaging Medical technology R855-855.5
Acceso en línea:	https://doaj.org/article/1f6073f316ac49db965a9fae640bd5f7
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spelling	oai:doaj.org-article:1f6073f316ac49db965a9fae640bd5f72021-12-05T12:21:27ZImaging features and differences among the three primary malignant non-Wilms tumors in children10.1186/s12880-021-00715-z1471-2342https://doaj.org/article/1f6073f316ac49db965a9fae640bd5f72021-12-01T00:00:00Zhttps://doi.org/10.1186/s12880-021-00715-zhttps://doaj.org/toc/1471-2342Abstract Background The pathology, treatment and prognosis of malignant non-Wilms tumors (NWTs) are different, so it is necessary to differentiate these types of tumors. The purpose of this study was to review the clinical and imaging features of malignant NWTs and features of tumor metastasis. Methods We retrospectively analyzed the CT images of 65 pediatric patients with NWTs from March 2008 to July 2020, mainly including clear cell sarcoma of the kidney (CCSK), malignant rhabdomyoma tumor of the kidney (MRTK) and renal cell carcinoma (RCC). Available pretreatment contrast-enhanced abdominal CT examinations were reviewed. The clinical features of the patients, imaging findings of the primary mass, and locoregional metastasis patterns were evaluated in correlation with pathological and surgical findings. Results The study included CCSK (22 cases), MRTK (27 cases) and RCC (16 cases). There were no significant differences observed among the sex ratios of CCSK, MRTK and RCC (all P > 0.05). Among the three tumors, the onset age of MRTK patients was the smallest, while that of RCC patients was the largest (all P < 0.05). The tumor diameter of CCSK was larger than that of MRTK and RCC (all P < 0.001). For hemorrhage and necrosis, the proportion of MRTK patients was larger than that of the other two tumors (P = 0.017). For calcification in tumors, the proportion of calcification in RCC was highest (P = 0.009). Only MRTK showed subcapsular fluid (P < 0.001). In the arterial phase, the proportion of slight enhancement in RCC was lower than that in the other two tumors (P = 0.007), and the proportion of marked enhancement was the highest (P = 0.002). In the venous phase, the proportion of slight enhancement in RCC was lower than that in the other two tumors (P < 0.001). Only CCSK had bone metastasis. There was no liver and lung metastasis in RCC. Conclusions NWTs have their own imaging and clinical manifestations. CCSK can cause vertebral metastasis, MRTK can cause subcapsular effusion, and RCC tumor density is usually high and calcification. These diagnostic points can play a role in clinical diagnosis.Yupeng ZhuWangxing FuYangyue HuangNing SunYun PengBMCarticleChildrenRenal tumorClear cell sarcoma of kidneyMalignant rhabdomyoma tumor of kidneyRenal cell carcinomaImagingMedical technologyR855-855.5ENBMC Medical Imaging, Vol 21, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Children Renal tumor Clear cell sarcoma of kidney Malignant rhabdomyoma tumor of kidney Renal cell carcinoma Imaging Medical technology R855-855.5
spellingShingle	Children Renal tumor Clear cell sarcoma of kidney Malignant rhabdomyoma tumor of kidney Renal cell carcinoma Imaging Medical technology R855-855.5 Yupeng Zhu Wangxing Fu Yangyue Huang Ning Sun Yun Peng Imaging features and differences among the three primary malignant non-Wilms tumors in children
description	Abstract Background The pathology, treatment and prognosis of malignant non-Wilms tumors (NWTs) are different, so it is necessary to differentiate these types of tumors. The purpose of this study was to review the clinical and imaging features of malignant NWTs and features of tumor metastasis. Methods We retrospectively analyzed the CT images of 65 pediatric patients with NWTs from March 2008 to July 2020, mainly including clear cell sarcoma of the kidney (CCSK), malignant rhabdomyoma tumor of the kidney (MRTK) and renal cell carcinoma (RCC). Available pretreatment contrast-enhanced abdominal CT examinations were reviewed. The clinical features of the patients, imaging findings of the primary mass, and locoregional metastasis patterns were evaluated in correlation with pathological and surgical findings. Results The study included CCSK (22 cases), MRTK (27 cases) and RCC (16 cases). There were no significant differences observed among the sex ratios of CCSK, MRTK and RCC (all P > 0.05). Among the three tumors, the onset age of MRTK patients was the smallest, while that of RCC patients was the largest (all P < 0.05). The tumor diameter of CCSK was larger than that of MRTK and RCC (all P < 0.001). For hemorrhage and necrosis, the proportion of MRTK patients was larger than that of the other two tumors (P = 0.017). For calcification in tumors, the proportion of calcification in RCC was highest (P = 0.009). Only MRTK showed subcapsular fluid (P < 0.001). In the arterial phase, the proportion of slight enhancement in RCC was lower than that in the other two tumors (P = 0.007), and the proportion of marked enhancement was the highest (P = 0.002). In the venous phase, the proportion of slight enhancement in RCC was lower than that in the other two tumors (P < 0.001). Only CCSK had bone metastasis. There was no liver and lung metastasis in RCC. Conclusions NWTs have their own imaging and clinical manifestations. CCSK can cause vertebral metastasis, MRTK can cause subcapsular effusion, and RCC tumor density is usually high and calcification. These diagnostic points can play a role in clinical diagnosis.
format	article
author	Yupeng Zhu Wangxing Fu Yangyue Huang Ning Sun Yun Peng
author_facet	Yupeng Zhu Wangxing Fu Yangyue Huang Ning Sun Yun Peng
author_sort	Yupeng Zhu
title	Imaging features and differences among the three primary malignant non-Wilms tumors in children
title_short	Imaging features and differences among the three primary malignant non-Wilms tumors in children
title_full	Imaging features and differences among the three primary malignant non-Wilms tumors in children
title_fullStr	Imaging features and differences among the three primary malignant non-Wilms tumors in children
title_full_unstemmed	Imaging features and differences among the three primary malignant non-Wilms tumors in children
title_sort	imaging features and differences among the three primary malignant non-wilms tumors in children
publisher	BMC
publishDate	2021
url	https://doaj.org/article/1f6073f316ac49db965a9fae640bd5f7
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Imaging features and differences among the three primary malignant non-Wilms tumors in children

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