Detection and Clinical Significance of Thrombus Molecular Markers in Diffuse Large B-cell Lymphoma

Objective To investigate the detection and clinical significance of thrombus molecular markers in diffuse large B-cell lymphoma (DLBCL). Methods We collected the blood specimens of 60 patients with DLBCL, involving 23 cases in the initial treatment group, 24 cases in the remission group and 13 cases...

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Autores principales:	WANG Yuhong, JIANG Xiujuan, CUI Jie, JIANG Junfeng, DUAN Yun
Formato:	article
Lenguaje:	ZH
Publicado:	Magazine House of Cancer Research on Prevention and Treatment 2021
Materias:	lymphoma thrombomodulin thrombin-antithrombin ⅲ complex tissue plasminogen activator-plasminogen activator inhibitor-1 complex plasmin-α2 plasmin inhibitor complex Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/1f629b4fb2ae4e83a024039970f38097
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spelling	oai:doaj.org-article:1f629b4fb2ae4e83a024039970f380972021-11-05T02:22:52ZDetection and Clinical Significance of Thrombus Molecular Markers in Diffuse Large B-cell Lymphoma1000-857810.3971/j.issn.1000-8578.2021.21.0222https://doaj.org/article/1f629b4fb2ae4e83a024039970f380972021-10-01T00:00:00Zhttp://html.rhhz.net/ZLFZYJ/html/8578.2020.21.0222.htmhttps://doaj.org/toc/1000-8578Objective To investigate the detection and clinical significance of thrombus molecular markers in diffuse large B-cell lymphoma (DLBCL). Methods We collected the blood specimens of 60 patients with DLBCL, involving 23 cases in the initial treatment group, 24 cases in the remission group and 13 cases in the non-remission group, 23 cases in the thrombus group and 37 cases in the non-thrombus group. We selected 46 healthy people in the same period as the control group. The levels of thrombomodulin (TM), plasmin-α2 plasmin inhibitor complex (PIC), tissue plasminogen activator-plasminogen activator inhibitor-1 complex (t-PAIC) and thrombin-antithrombin Ⅲ complex (TAT) in plasma were detected by chemical immunoassay, and the levels of lactate dehydrogenase (LDH) in serum was detected by automatic biochemical analyzer. We analyzed the differences of thrombus molecular markers among groups and prognostic factors. Results The levels of TM and PIC in plasma of lymphoma patients were higher than those in health control group (P < 0.05). The levels of TM and PIC in the initial treatment and non-remission groups were significantly higher than those in the remission group (P < 0.05). The levels of TM, PIC and TAT in thrombus group were higher than those in non-thrombus group (P < 0.05). TM and PIC levels in plasma were closely related to the prognosis of DLBCL patients. PIC was an independent prognostic factor (P < 0.001). TM and PIC levels were correlated with LDH prognostic indicators in lymphoma patients. Conclusion TM and PIC levels in plasma are significantly increased in DLBCL patients. They are expected to be the indicators for effectiveness and prognosis of DLBCL patients.WANG YuhongJIANG XiujuanCUI JieJIANG JunfengDUAN YunMagazine House of Cancer Research on Prevention and Treatmentarticlelymphomathrombomodulinthrombin-antithrombin ⅲ complextissue plasminogen activator-plasminogen activator inhibitor-1 complexplasmin-α2 plasmin inhibitor complexNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ZHZhongliu Fangzhi Yanjiu, Vol 48, Iss 10, Pp 947-951 (2021)
institution	DOAJ
collection	DOAJ
language	ZH
topic	lymphoma thrombomodulin thrombin-antithrombin ⅲ complex tissue plasminogen activator-plasminogen activator inhibitor-1 complex plasmin-α2 plasmin inhibitor complex Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	lymphoma thrombomodulin thrombin-antithrombin ⅲ complex tissue plasminogen activator-plasminogen activator inhibitor-1 complex plasmin-α2 plasmin inhibitor complex Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 WANG Yuhong JIANG Xiujuan CUI Jie JIANG Junfeng DUAN Yun Detection and Clinical Significance of Thrombus Molecular Markers in Diffuse Large B-cell Lymphoma
description	Objective To investigate the detection and clinical significance of thrombus molecular markers in diffuse large B-cell lymphoma (DLBCL). Methods We collected the blood specimens of 60 patients with DLBCL, involving 23 cases in the initial treatment group, 24 cases in the remission group and 13 cases in the non-remission group, 23 cases in the thrombus group and 37 cases in the non-thrombus group. We selected 46 healthy people in the same period as the control group. The levels of thrombomodulin (TM), plasmin-α2 plasmin inhibitor complex (PIC), tissue plasminogen activator-plasminogen activator inhibitor-1 complex (t-PAIC) and thrombin-antithrombin Ⅲ complex (TAT) in plasma were detected by chemical immunoassay, and the levels of lactate dehydrogenase (LDH) in serum was detected by automatic biochemical analyzer. We analyzed the differences of thrombus molecular markers among groups and prognostic factors. Results The levels of TM and PIC in plasma of lymphoma patients were higher than those in health control group (P < 0.05). The levels of TM and PIC in the initial treatment and non-remission groups were significantly higher than those in the remission group (P < 0.05). The levels of TM, PIC and TAT in thrombus group were higher than those in non-thrombus group (P < 0.05). TM and PIC levels in plasma were closely related to the prognosis of DLBCL patients. PIC was an independent prognostic factor (P < 0.001). TM and PIC levels were correlated with LDH prognostic indicators in lymphoma patients. Conclusion TM and PIC levels in plasma are significantly increased in DLBCL patients. They are expected to be the indicators for effectiveness and prognosis of DLBCL patients.
format	article
author	WANG Yuhong JIANG Xiujuan CUI Jie JIANG Junfeng DUAN Yun
author_facet	WANG Yuhong JIANG Xiujuan CUI Jie JIANG Junfeng DUAN Yun
author_sort	WANG Yuhong
title	Detection and Clinical Significance of Thrombus Molecular Markers in Diffuse Large B-cell Lymphoma
title_short	Detection and Clinical Significance of Thrombus Molecular Markers in Diffuse Large B-cell Lymphoma
title_full	Detection and Clinical Significance of Thrombus Molecular Markers in Diffuse Large B-cell Lymphoma
title_fullStr	Detection and Clinical Significance of Thrombus Molecular Markers in Diffuse Large B-cell Lymphoma
title_full_unstemmed	Detection and Clinical Significance of Thrombus Molecular Markers in Diffuse Large B-cell Lymphoma
title_sort	detection and clinical significance of thrombus molecular markers in diffuse large b-cell lymphoma
publisher	Magazine House of Cancer Research on Prevention and Treatment
publishDate	2021
url	https://doaj.org/article/1f629b4fb2ae4e83a024039970f38097
work_keys_str_mv	AT wangyuhong detectionandclinicalsignificanceofthrombusmolecularmarkersindiffuselargebcelllymphoma AT jiangxiujuan detectionandclinicalsignificanceofthrombusmolecularmarkersindiffuselargebcelllymphoma AT cuijie detectionandclinicalsignificanceofthrombusmolecularmarkersindiffuselargebcelllymphoma AT jiangjunfeng detectionandclinicalsignificanceofthrombusmolecularmarkersindiffuselargebcelllymphoma AT duanyun detectionandclinicalsignificanceofthrombusmolecularmarkersindiffuselargebcelllymphoma
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Detection and Clinical Significance of Thrombus Molecular Markers in Diffuse Large B-cell Lymphoma

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