Liver-specific ATP-citrate lyase inhibition by bempedoic acid decreases LDL-C and attenuates atherosclerosis

Statins are lipid-lowering drugs that prevent cardiovascular disease but tolerability is limited by severe side effects in muscles. Here the authors elucidate a liver-specific activation mechanism for bempedoic acid, a novel cholesterol-lowering drug, and show how it effectively reduces LDL-C and at...

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Autores principales:	Stephen L. Pinkosky, Roger S. Newton, Emily A. Day, Rebecca J. Ford, Sarka Lhotak, Richard C. Austin, Carolyn M. Birch, Brennan K. Smith, Sergey Filippov, Pieter H.E. Groot, Gregory R. Steinberg, Narendra D. Lalwani
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1f66c328c6054aecb4400856a6c02de9
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spelling	oai:doaj.org-article:1f66c328c6054aecb4400856a6c02de92021-12-02T14:39:15ZLiver-specific ATP-citrate lyase inhibition by bempedoic acid decreases LDL-C and attenuates atherosclerosis10.1038/ncomms134572041-1723https://doaj.org/article/1f66c328c6054aecb4400856a6c02de92016-11-01T00:00:00Zhttps://doi.org/10.1038/ncomms13457https://doaj.org/toc/2041-1723Statins are lipid-lowering drugs that prevent cardiovascular disease but tolerability is limited by severe side effects in muscles. Here the authors elucidate a liver-specific activation mechanism for bempedoic acid, a novel cholesterol-lowering drug, and show how it effectively reduces LDL-C and atherosclerotic burden in mice, but does not cause myotoxicty.Stephen L. PinkoskyRoger S. NewtonEmily A. DayRebecca J. FordSarka LhotakRichard C. AustinCarolyn M. BirchBrennan K. SmithSergey FilippovPieter H.E. GrootGregory R. SteinbergNarendra D. LalwaniNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Stephen L. Pinkosky Roger S. Newton Emily A. Day Rebecca J. Ford Sarka Lhotak Richard C. Austin Carolyn M. Birch Brennan K. Smith Sergey Filippov Pieter H.E. Groot Gregory R. Steinberg Narendra D. Lalwani Liver-specific ATP-citrate lyase inhibition by bempedoic acid decreases LDL-C and attenuates atherosclerosis
description	Statins are lipid-lowering drugs that prevent cardiovascular disease but tolerability is limited by severe side effects in muscles. Here the authors elucidate a liver-specific activation mechanism for bempedoic acid, a novel cholesterol-lowering drug, and show how it effectively reduces LDL-C and atherosclerotic burden in mice, but does not cause myotoxicty.
format	article
author	Stephen L. Pinkosky Roger S. Newton Emily A. Day Rebecca J. Ford Sarka Lhotak Richard C. Austin Carolyn M. Birch Brennan K. Smith Sergey Filippov Pieter H.E. Groot Gregory R. Steinberg Narendra D. Lalwani
author_facet	Stephen L. Pinkosky Roger S. Newton Emily A. Day Rebecca J. Ford Sarka Lhotak Richard C. Austin Carolyn M. Birch Brennan K. Smith Sergey Filippov Pieter H.E. Groot Gregory R. Steinberg Narendra D. Lalwani
author_sort	Stephen L. Pinkosky
title	Liver-specific ATP-citrate lyase inhibition by bempedoic acid decreases LDL-C and attenuates atherosclerosis
title_short	Liver-specific ATP-citrate lyase inhibition by bempedoic acid decreases LDL-C and attenuates atherosclerosis
title_full	Liver-specific ATP-citrate lyase inhibition by bempedoic acid decreases LDL-C and attenuates atherosclerosis
title_fullStr	Liver-specific ATP-citrate lyase inhibition by bempedoic acid decreases LDL-C and attenuates atherosclerosis
title_full_unstemmed	Liver-specific ATP-citrate lyase inhibition by bempedoic acid decreases LDL-C and attenuates atherosclerosis
title_sort	liver-specific atp-citrate lyase inhibition by bempedoic acid decreases ldl-c and attenuates atherosclerosis
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/1f66c328c6054aecb4400856a6c02de9
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Liver-specific ATP-citrate lyase inhibition by bempedoic acid decreases LDL-C and attenuates atherosclerosis

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