Short-Term Aerobic Exercise Did Not Change Telomere Length While It Reduced Testosterone Levels and Obesity Indexes in PCOS: A Randomized Controlled Clinical Trial Study
Metabolic and hormonal outcomes of polycystic ovary syndrome (PCOS) have implications on telomere biology and physical activity may prevent telomere erosion. We sought to observe the effects of continuous (CAT) and intermittent (IAT) aerobic training on telomere length, inflammatory biomarkers, and...
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oai:doaj.org-article:1f6d0598870b43608bd923ccde519ed42021-11-11T16:26:08ZShort-Term Aerobic Exercise Did Not Change Telomere Length While It Reduced Testosterone Levels and Obesity Indexes in PCOS: A Randomized Controlled Clinical Trial Study10.3390/ijerph1821112741660-46011661-7827https://doaj.org/article/1f6d0598870b43608bd923ccde519ed42021-10-01T00:00:00Zhttps://www.mdpi.com/1660-4601/18/21/11274https://doaj.org/toc/1661-7827https://doaj.org/toc/1660-4601Metabolic and hormonal outcomes of polycystic ovary syndrome (PCOS) have implications on telomere biology and physical activity may prevent telomere erosion. We sought to observe the effects of continuous (CAT) and intermittent (IAT) aerobic training on telomere length, inflammatory biomarkers, and its correlation with metabolic, hormonal, and anthropometric parameters of PCOS. This randomized controlled clinical trial study included 87 PCOS randomly stratified according to body mass index (BMI) in CAT (<i>n</i> = 28), IAT (<i>n</i> = 29) and non-training control group (CG, <i>n</i> = 30). The exercises were carried out on a treadmill, three times per week for 16 weeks. The participants’ anthropometric characteristics and biochemical and hormonal concentrations were measured before and after aerobic training or observation period, as the telomere length that was evaluated using quantitative real-time PCR. Four months of aerobic exercises (CAT or IAT) did not alter telomere length and inflammatory biomarkers in PCOS women. Obesity index as BMI and waist circumference (WC), and inflammatory biomarkers negatively affect telomeres. The hyper-andro-genism measured by testosterone levels was reduced after both exercises (CAT, <i>p</i> ≤ 0.001; IAT, <i>p</i> = 0.019). In particular, the CAT reduced WC (<i>p</i> = 0.045), hip circumference (<i>p</i> = 0.032), serum cholesterol (<i>p</i> ≤ 0.001), and low-density lipoprotein (<i>p</i> = 0.030). Whereas, the IAT decreased WC (<i>p</i> = 0.014), waist-to-hip ratio (<i>p</i> = 0.012), free androgen index (FAI) (<i>p</i> = 0.037). WC (<i>p</i> = 0.049) and body fat (<i>p</i> = 0.015) increased in the non-training group while total cholesterol was reduced (<i>p</i> = 0.010). Booth exercises reduced obesity indices and hyperandrogenism on PCOS women without changes in telomere length or inflammatory biomarkers.Victor Barbosa RibeiroDaiana Cristina Chielli PedrosoGislaine Satyko KogureIris Palma LopesBarbara Aparecida SantanaHugo Celso Dutra de SouzaRui Alberto FerrianiRodrigo Tocantins CaladoCristiana Libardi Miranda FurtadoRosana Maria dos ReisMDPI AGarticlepolycystic ovary syndromeaerobic physical trainingtelomere lengthbody compositionhyperandrogenismMedicineRENInternational Journal of Environmental Research and Public Health, Vol 18, Iss 11274, p 11274 (2021) |
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polycystic ovary syndrome aerobic physical training telomere length body composition hyperandrogenism Medicine R |
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polycystic ovary syndrome aerobic physical training telomere length body composition hyperandrogenism Medicine R Victor Barbosa Ribeiro Daiana Cristina Chielli Pedroso Gislaine Satyko Kogure Iris Palma Lopes Barbara Aparecida Santana Hugo Celso Dutra de Souza Rui Alberto Ferriani Rodrigo Tocantins Calado Cristiana Libardi Miranda Furtado Rosana Maria dos Reis Short-Term Aerobic Exercise Did Not Change Telomere Length While It Reduced Testosterone Levels and Obesity Indexes in PCOS: A Randomized Controlled Clinical Trial Study |
| description |
Metabolic and hormonal outcomes of polycystic ovary syndrome (PCOS) have implications on telomere biology and physical activity may prevent telomere erosion. We sought to observe the effects of continuous (CAT) and intermittent (IAT) aerobic training on telomere length, inflammatory biomarkers, and its correlation with metabolic, hormonal, and anthropometric parameters of PCOS. This randomized controlled clinical trial study included 87 PCOS randomly stratified according to body mass index (BMI) in CAT (<i>n</i> = 28), IAT (<i>n</i> = 29) and non-training control group (CG, <i>n</i> = 30). The exercises were carried out on a treadmill, three times per week for 16 weeks. The participants’ anthropometric characteristics and biochemical and hormonal concentrations were measured before and after aerobic training or observation period, as the telomere length that was evaluated using quantitative real-time PCR. Four months of aerobic exercises (CAT or IAT) did not alter telomere length and inflammatory biomarkers in PCOS women. Obesity index as BMI and waist circumference (WC), and inflammatory biomarkers negatively affect telomeres. The hyper-andro-genism measured by testosterone levels was reduced after both exercises (CAT, <i>p</i> ≤ 0.001; IAT, <i>p</i> = 0.019). In particular, the CAT reduced WC (<i>p</i> = 0.045), hip circumference (<i>p</i> = 0.032), serum cholesterol (<i>p</i> ≤ 0.001), and low-density lipoprotein (<i>p</i> = 0.030). Whereas, the IAT decreased WC (<i>p</i> = 0.014), waist-to-hip ratio (<i>p</i> = 0.012), free androgen index (FAI) (<i>p</i> = 0.037). WC (<i>p</i> = 0.049) and body fat (<i>p</i> = 0.015) increased in the non-training group while total cholesterol was reduced (<i>p</i> = 0.010). Booth exercises reduced obesity indices and hyperandrogenism on PCOS women without changes in telomere length or inflammatory biomarkers. |
| format |
article |
| author |
Victor Barbosa Ribeiro Daiana Cristina Chielli Pedroso Gislaine Satyko Kogure Iris Palma Lopes Barbara Aparecida Santana Hugo Celso Dutra de Souza Rui Alberto Ferriani Rodrigo Tocantins Calado Cristiana Libardi Miranda Furtado Rosana Maria dos Reis |
| author_facet |
Victor Barbosa Ribeiro Daiana Cristina Chielli Pedroso Gislaine Satyko Kogure Iris Palma Lopes Barbara Aparecida Santana Hugo Celso Dutra de Souza Rui Alberto Ferriani Rodrigo Tocantins Calado Cristiana Libardi Miranda Furtado Rosana Maria dos Reis |
| author_sort |
Victor Barbosa Ribeiro |
| title |
Short-Term Aerobic Exercise Did Not Change Telomere Length While It Reduced Testosterone Levels and Obesity Indexes in PCOS: A Randomized Controlled Clinical Trial Study |
| title_short |
Short-Term Aerobic Exercise Did Not Change Telomere Length While It Reduced Testosterone Levels and Obesity Indexes in PCOS: A Randomized Controlled Clinical Trial Study |
| title_full |
Short-Term Aerobic Exercise Did Not Change Telomere Length While It Reduced Testosterone Levels and Obesity Indexes in PCOS: A Randomized Controlled Clinical Trial Study |
| title_fullStr |
Short-Term Aerobic Exercise Did Not Change Telomere Length While It Reduced Testosterone Levels and Obesity Indexes in PCOS: A Randomized Controlled Clinical Trial Study |
| title_full_unstemmed |
Short-Term Aerobic Exercise Did Not Change Telomere Length While It Reduced Testosterone Levels and Obesity Indexes in PCOS: A Randomized Controlled Clinical Trial Study |
| title_sort |
short-term aerobic exercise did not change telomere length while it reduced testosterone levels and obesity indexes in pcos: a randomized controlled clinical trial study |
| publisher |
MDPI AG |
| publishDate |
2021 |
| url |
https://doaj.org/article/1f6d0598870b43608bd923ccde519ed4 |
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