Vasculogenic mimicry in small cell lung cancer
Small cell lung cancer (SCLC) is characterised by prevalent circulating tumour cells (CTCs), early metastasis and poor prognosis. The authors show that SCLC patients have a rare CTC subset with a vasculogenic mimicry (VM) phenotype, and that VM is associated with worse overall survival, and alters t...
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Nature Portfolio
2016
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oai:doaj.org-article:1f6ee31f432d40e09b2cc3b50bd9c6222021-12-02T15:34:52ZVasculogenic mimicry in small cell lung cancer10.1038/ncomms133222041-1723https://doaj.org/article/1f6ee31f432d40e09b2cc3b50bd9c6222016-11-01T00:00:00Zhttps://doi.org/10.1038/ncomms13322https://doaj.org/toc/2041-1723Small cell lung cancer (SCLC) is characterised by prevalent circulating tumour cells (CTCs), early metastasis and poor prognosis. The authors show that SCLC patients have a rare CTC subset with a vasculogenic mimicry (VM) phenotype, and that VM is associated with worse overall survival, and alters tumour growth, chemotherapy delivery and efficacy.Stuart C. WilliamsonRobert L. MetcalfFrancesca TrapaniSumitra MohanJenny AntonelloBenjamin AbbottHui Sun LeongChristopher P. E. ChesterNicole SimmsRadoslaw PolanskiDaisuke NonakaLynsey PriestAlberto FusiFredrika CarlssonAnders CarlssonMary J. C. HendrixRichard E. B. SeftorElisabeth A. SeftorDominic G. RothwellAndrew HughesJames HicksCrispin MillerPeter KuhnGed BradyKathryn L. SimpsonFiona H. BlackhallCaroline DiveNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-14 (2016) |
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DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Stuart C. Williamson Robert L. Metcalf Francesca Trapani Sumitra Mohan Jenny Antonello Benjamin Abbott Hui Sun Leong Christopher P. E. Chester Nicole Simms Radoslaw Polanski Daisuke Nonaka Lynsey Priest Alberto Fusi Fredrika Carlsson Anders Carlsson Mary J. C. Hendrix Richard E. B. Seftor Elisabeth A. Seftor Dominic G. Rothwell Andrew Hughes James Hicks Crispin Miller Peter Kuhn Ged Brady Kathryn L. Simpson Fiona H. Blackhall Caroline Dive Vasculogenic mimicry in small cell lung cancer |
| description |
Small cell lung cancer (SCLC) is characterised by prevalent circulating tumour cells (CTCs), early metastasis and poor prognosis. The authors show that SCLC patients have a rare CTC subset with a vasculogenic mimicry (VM) phenotype, and that VM is associated with worse overall survival, and alters tumour growth, chemotherapy delivery and efficacy. |
| format |
article |
| author |
Stuart C. Williamson Robert L. Metcalf Francesca Trapani Sumitra Mohan Jenny Antonello Benjamin Abbott Hui Sun Leong Christopher P. E. Chester Nicole Simms Radoslaw Polanski Daisuke Nonaka Lynsey Priest Alberto Fusi Fredrika Carlsson Anders Carlsson Mary J. C. Hendrix Richard E. B. Seftor Elisabeth A. Seftor Dominic G. Rothwell Andrew Hughes James Hicks Crispin Miller Peter Kuhn Ged Brady Kathryn L. Simpson Fiona H. Blackhall Caroline Dive |
| author_facet |
Stuart C. Williamson Robert L. Metcalf Francesca Trapani Sumitra Mohan Jenny Antonello Benjamin Abbott Hui Sun Leong Christopher P. E. Chester Nicole Simms Radoslaw Polanski Daisuke Nonaka Lynsey Priest Alberto Fusi Fredrika Carlsson Anders Carlsson Mary J. C. Hendrix Richard E. B. Seftor Elisabeth A. Seftor Dominic G. Rothwell Andrew Hughes James Hicks Crispin Miller Peter Kuhn Ged Brady Kathryn L. Simpson Fiona H. Blackhall Caroline Dive |
| author_sort |
Stuart C. Williamson |
| title |
Vasculogenic mimicry in small cell lung cancer |
| title_short |
Vasculogenic mimicry in small cell lung cancer |
| title_full |
Vasculogenic mimicry in small cell lung cancer |
| title_fullStr |
Vasculogenic mimicry in small cell lung cancer |
| title_full_unstemmed |
Vasculogenic mimicry in small cell lung cancer |
| title_sort |
vasculogenic mimicry in small cell lung cancer |
| publisher |
Nature Portfolio |
| publishDate |
2016 |
| url |
https://doaj.org/article/1f6ee31f432d40e09b2cc3b50bd9c622 |
| work_keys_str_mv |
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