Prescription medicines and the risk of road traffic crashes: a French registry-based study.

<h4>Background</h4>In recent decades, increased attention has been focused on the impact of disabilities and medicinal drug use on road safety. The aim of our study was to investigate the association between prescription medicines and the risk of road traffic crashes, and estimate the at...

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Autores principales:	Ludivine Orriols, Bernard Delorme, Blandine Gadegbeku, Aurore Tricotel, Benjamin Contrand, Bernard Laumon, Louis-Rachid Salmi, Emmanuel Lagarde, CESIR research group
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2010
Materias:	Medicine R
Acceso en línea:	https://doaj.org/article/1f71d05e9f274c5798198080502ebadd
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spelling	oai:doaj.org-article:1f71d05e9f274c5798198080502ebadd2021-11-18T05:42:30ZPrescription medicines and the risk of road traffic crashes: a French registry-based study.1549-12771549-167610.1371/journal.pmed.1000366https://doaj.org/article/1f71d05e9f274c5798198080502ebadd2010-11-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21125020/?tool=EBIhttps://doaj.org/toc/1549-1277https://doaj.org/toc/1549-1676<h4>Background</h4>In recent decades, increased attention has been focused on the impact of disabilities and medicinal drug use on road safety. The aim of our study was to investigate the association between prescription medicines and the risk of road traffic crashes, and estimate the attributable fraction.<h4>Methods and findings</h4>We extracted and matched data from three French nationwide databases: the national health care insurance database, police reports, and the national police database of injurious crashes. Drivers identified by their national health care number involved in an injurious crash in France, between July 2005 and May 2008, were included in the study. Medicines were grouped according to the four risk levels of the French classification system (from 0 [no risk] to 3 [high risk]). We included 72,685 drivers involved in injurious crashes. Users of level 2 (odds ratio [OR] = 1.31 [1.24-1.40]) and level 3 (OR = 1.25 [1.12-1.40]) prescription medicines were at higher risk of being responsible for a crash. The association remained after adjustment for the presence of a long-term chronic disease. The fraction of road traffic crashes attributable to levels 2 and 3 medications was 3.3% [2.7%-3.9%]. A within-person case-crossover analysis showed that drivers were more likely to be exposed to level 3 medications on the crash day than on a control day, 30 days earlier (OR = 1.15 [1.05-1.27]).<h4>Conclusion</h4>The use of prescription medicines is associated with a substantial number of road traffic crashes in France. In light of the results, warning messages appear to be relevant for level 2 and 3 medications and questionable for level 1 medications. A follow-up study is needed to evaluate the impact of the warning labeling system on road traffic crash prevention.Ludivine OrriolsBernard DelormeBlandine GadegbekuAurore TricotelBenjamin ContrandBernard LaumonLouis-Rachid SalmiEmmanuel LagardeCESIR research groupPublic Library of Science (PLoS)articleMedicineRENPLoS Medicine, Vol 7, Iss 11, p e1000366 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R
spellingShingle	Medicine R Ludivine Orriols Bernard Delorme Blandine Gadegbeku Aurore Tricotel Benjamin Contrand Bernard Laumon Louis-Rachid Salmi Emmanuel Lagarde CESIR research group Prescription medicines and the risk of road traffic crashes: a French registry-based study.
description	<h4>Background</h4>In recent decades, increased attention has been focused on the impact of disabilities and medicinal drug use on road safety. The aim of our study was to investigate the association between prescription medicines and the risk of road traffic crashes, and estimate the attributable fraction.<h4>Methods and findings</h4>We extracted and matched data from three French nationwide databases: the national health care insurance database, police reports, and the national police database of injurious crashes. Drivers identified by their national health care number involved in an injurious crash in France, between July 2005 and May 2008, were included in the study. Medicines were grouped according to the four risk levels of the French classification system (from 0 [no risk] to 3 [high risk]). We included 72,685 drivers involved in injurious crashes. Users of level 2 (odds ratio [OR] = 1.31 [1.24-1.40]) and level 3 (OR = 1.25 [1.12-1.40]) prescription medicines were at higher risk of being responsible for a crash. The association remained after adjustment for the presence of a long-term chronic disease. The fraction of road traffic crashes attributable to levels 2 and 3 medications was 3.3% [2.7%-3.9%]. A within-person case-crossover analysis showed that drivers were more likely to be exposed to level 3 medications on the crash day than on a control day, 30 days earlier (OR = 1.15 [1.05-1.27]).<h4>Conclusion</h4>The use of prescription medicines is associated with a substantial number of road traffic crashes in France. In light of the results, warning messages appear to be relevant for level 2 and 3 medications and questionable for level 1 medications. A follow-up study is needed to evaluate the impact of the warning labeling system on road traffic crash prevention.
format	article
author	Ludivine Orriols Bernard Delorme Blandine Gadegbeku Aurore Tricotel Benjamin Contrand Bernard Laumon Louis-Rachid Salmi Emmanuel Lagarde CESIR research group
author_facet	Ludivine Orriols Bernard Delorme Blandine Gadegbeku Aurore Tricotel Benjamin Contrand Bernard Laumon Louis-Rachid Salmi Emmanuel Lagarde CESIR research group
author_sort	Ludivine Orriols
title	Prescription medicines and the risk of road traffic crashes: a French registry-based study.
title_short	Prescription medicines and the risk of road traffic crashes: a French registry-based study.
title_full	Prescription medicines and the risk of road traffic crashes: a French registry-based study.
title_fullStr	Prescription medicines and the risk of road traffic crashes: a French registry-based study.
title_full_unstemmed	Prescription medicines and the risk of road traffic crashes: a French registry-based study.
title_sort	prescription medicines and the risk of road traffic crashes: a french registry-based study.
publisher	Public Library of Science (PLoS)
publishDate	2010
url	https://doaj.org/article/1f71d05e9f274c5798198080502ebadd
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Prescription medicines and the risk of road traffic crashes: a French registry-based study.

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