Disrupted lymph node and splenic stroma in mice with induced inflammatory melanomas is associated with impaired recruitment of T and dendritic cells.

Disrupted lymph node and splenic stroma in mice with induced inflammatory melanomas is associated with impaired recruitment of T and dendritic cells.

Migration of dendritic cells (DC) from the tumor environment to the T cell cortex in tumor-draining lymph nodes (TDLN) is essential for priming naïve T lymphocytes (TL) to tumor antigen (Ag). We used a mouse model of induced melanoma in which similar oncogenic events generate two phenotypically dist...

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Autores principales: Saïdi M Soudja, Sandrine Henri, Marielle Mello, Lionel Chasson, Amandine Mas, Maria Wehbe, Nathalie Auphan-Anezin, Lee Leserman, Benoît Van den Eynde, Anne-Marie Schmitt-Verhulst
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2011
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/1f7425e84e524386a019f0d136cc58e1
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