P-selectin axis plays a key role in microglia immunophenotype and glioblastoma progression
Glioma-associated microglia/macrophages are central drivers of brain tumor pathology. Here the authors characterize the role of the P-selectin/PSGL-1 axis in the cross-talk between glioblastoma cells and microglia/macrophages and show that the therapeutic targeting of P-selectin limits glioblastoma...
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Nature Portfolio
2021
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| Acceso en línea: | https://doaj.org/article/1f79e03ac9e64447af84689d42d725ab |
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oai:doaj.org-article:1f79e03ac9e64447af84689d42d725ab2021-12-02T17:04:30ZP-selectin axis plays a key role in microglia immunophenotype and glioblastoma progression10.1038/s41467-021-22186-02041-1723https://doaj.org/article/1f79e03ac9e64447af84689d42d725ab2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22186-0https://doaj.org/toc/2041-1723Glioma-associated microglia/macrophages are central drivers of brain tumor pathology. Here the authors characterize the role of the P-selectin/PSGL-1 axis in the cross-talk between glioblastoma cells and microglia/macrophages and show that the therapeutic targeting of P-selectin limits glioblastoma progression in preclinical models.Eilam YeiniPaula OfekSabina PozziNitzan AlbeckDikla Ben-ShushanGalia TiramSapir GolanRon KleinerRon SheininSahar Israeli DangoorShlomit Reich-ZeligerRachel GrossmanZvi RamHenry BremThomas M. HydePrerna MagodDinorah Friedmann-MorvinskiAsaf MadiRonit Satchi-FainaroNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-22 (2021) |
| institution |
DOAJ |
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DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Eilam Yeini Paula Ofek Sabina Pozzi Nitzan Albeck Dikla Ben-Shushan Galia Tiram Sapir Golan Ron Kleiner Ron Sheinin Sahar Israeli Dangoor Shlomit Reich-Zeliger Rachel Grossman Zvi Ram Henry Brem Thomas M. Hyde Prerna Magod Dinorah Friedmann-Morvinski Asaf Madi Ronit Satchi-Fainaro P-selectin axis plays a key role in microglia immunophenotype and glioblastoma progression |
| description |
Glioma-associated microglia/macrophages are central drivers of brain tumor pathology. Here the authors characterize the role of the P-selectin/PSGL-1 axis in the cross-talk between glioblastoma cells and microglia/macrophages and show that the therapeutic targeting of P-selectin limits glioblastoma progression in preclinical models. |
| format |
article |
| author |
Eilam Yeini Paula Ofek Sabina Pozzi Nitzan Albeck Dikla Ben-Shushan Galia Tiram Sapir Golan Ron Kleiner Ron Sheinin Sahar Israeli Dangoor Shlomit Reich-Zeliger Rachel Grossman Zvi Ram Henry Brem Thomas M. Hyde Prerna Magod Dinorah Friedmann-Morvinski Asaf Madi Ronit Satchi-Fainaro |
| author_facet |
Eilam Yeini Paula Ofek Sabina Pozzi Nitzan Albeck Dikla Ben-Shushan Galia Tiram Sapir Golan Ron Kleiner Ron Sheinin Sahar Israeli Dangoor Shlomit Reich-Zeliger Rachel Grossman Zvi Ram Henry Brem Thomas M. Hyde Prerna Magod Dinorah Friedmann-Morvinski Asaf Madi Ronit Satchi-Fainaro |
| author_sort |
Eilam Yeini |
| title |
P-selectin axis plays a key role in microglia immunophenotype and glioblastoma progression |
| title_short |
P-selectin axis plays a key role in microglia immunophenotype and glioblastoma progression |
| title_full |
P-selectin axis plays a key role in microglia immunophenotype and glioblastoma progression |
| title_fullStr |
P-selectin axis plays a key role in microglia immunophenotype and glioblastoma progression |
| title_full_unstemmed |
P-selectin axis plays a key role in microglia immunophenotype and glioblastoma progression |
| title_sort |
p-selectin axis plays a key role in microglia immunophenotype and glioblastoma progression |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/1f79e03ac9e64447af84689d42d725ab |
| work_keys_str_mv |
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