Early life influences kidney function at age 63-64 years, but so does adult body size: results from the newcastle thousand families birth cohort.

<h4>Background</h4>It is suggested that impaired fetal growth can affect kidney development, resulting in fewer glomeruli being formed and reduced kidney function later in life. The aim of this study was to investigate early life variables in relation to adult kidney function, and compar...

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Autores principales:	Stephanie L Harrison, Kay D Mann, Mark S Pearce
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1f7a4255c46a4c6ebb789b66bc01f536
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spelling	oai:doaj.org-article:1f7a4255c46a4c6ebb789b66bc01f5362021-11-18T07:41:48ZEarly life influences kidney function at age 63-64 years, but so does adult body size: results from the newcastle thousand families birth cohort.1932-620310.1371/journal.pone.0066660https://doaj.org/article/1f7a4255c46a4c6ebb789b66bc01f5362013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23785509/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>It is suggested that impaired fetal growth can affect kidney development, resulting in fewer glomeruli being formed and reduced kidney function later in life. The aim of this study was to investigate early life variables in relation to adult kidney function, and compare these to the influence of later life variables.<h4>Methods</h4>Detailed information was collected prospectively regarding 1,142 babies, born in 1947 in Newcastle upon Tyne. At the age of 63-64 years, 335 participants had serum creatinine successfully measured and completed a lifestyle questionnaire. These measurements were used to calculate their estimated glomerular filtration rate (eGFR).<h4>Results</h4>Body mass index (BMI) and being female were significantly negatively associated with eGFR. Birth weight was significantly positively associated with eGFR. In sex-specific analyses, BMI and cigarette smoking remained significant for males (n = 154), with a near significant association for birth weight, whereas none of the variables remained significant for females (n = 181).<h4>Conclusions</h4>The findings suggest that sex, size at birth and BMI may be important variables influencing adult kidney function. However, as only a small amount of variance in eGFR was explained by these variables, additional longitudinal studies would be beneficial for assessing lifecourse influences on kidney function.Stephanie L HarrisonKay D MannMark S PearcePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 6, p e66660 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Stephanie L Harrison Kay D Mann Mark S Pearce Early life influences kidney function at age 63-64 years, but so does adult body size: results from the newcastle thousand families birth cohort.
description	<h4>Background</h4>It is suggested that impaired fetal growth can affect kidney development, resulting in fewer glomeruli being formed and reduced kidney function later in life. The aim of this study was to investigate early life variables in relation to adult kidney function, and compare these to the influence of later life variables.<h4>Methods</h4>Detailed information was collected prospectively regarding 1,142 babies, born in 1947 in Newcastle upon Tyne. At the age of 63-64 years, 335 participants had serum creatinine successfully measured and completed a lifestyle questionnaire. These measurements were used to calculate their estimated glomerular filtration rate (eGFR).<h4>Results</h4>Body mass index (BMI) and being female were significantly negatively associated with eGFR. Birth weight was significantly positively associated with eGFR. In sex-specific analyses, BMI and cigarette smoking remained significant for males (n = 154), with a near significant association for birth weight, whereas none of the variables remained significant for females (n = 181).<h4>Conclusions</h4>The findings suggest that sex, size at birth and BMI may be important variables influencing adult kidney function. However, as only a small amount of variance in eGFR was explained by these variables, additional longitudinal studies would be beneficial for assessing lifecourse influences on kidney function.
format	article
author	Stephanie L Harrison Kay D Mann Mark S Pearce
author_facet	Stephanie L Harrison Kay D Mann Mark S Pearce
author_sort	Stephanie L Harrison
title	Early life influences kidney function at age 63-64 years, but so does adult body size: results from the newcastle thousand families birth cohort.
title_short	Early life influences kidney function at age 63-64 years, but so does adult body size: results from the newcastle thousand families birth cohort.
title_full	Early life influences kidney function at age 63-64 years, but so does adult body size: results from the newcastle thousand families birth cohort.
title_fullStr	Early life influences kidney function at age 63-64 years, but so does adult body size: results from the newcastle thousand families birth cohort.
title_full_unstemmed	Early life influences kidney function at age 63-64 years, but so does adult body size: results from the newcastle thousand families birth cohort.
title_sort	early life influences kidney function at age 63-64 years, but so does adult body size: results from the newcastle thousand families birth cohort.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/1f7a4255c46a4c6ebb789b66bc01f536
work_keys_str_mv	AT stephanielharrison earlylifeinfluenceskidneyfunctionatage6364yearsbutsodoesadultbodysizeresultsfromthenewcastlethousandfamiliesbirthcohort AT kaydmann earlylifeinfluenceskidneyfunctionatage6364yearsbutsodoesadultbodysizeresultsfromthenewcastlethousandfamiliesbirthcohort AT markspearce earlylifeinfluenceskidneyfunctionatage6364yearsbutsodoesadultbodysizeresultsfromthenewcastlethousandfamiliesbirthcohort
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Early life influences kidney function at age 63-64 years, but so does adult body size: results from the newcastle thousand families birth cohort.

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