Unpredictable feeding impairs glucose tolerance in growing lambs.

Irregular eating is associated with insulin resistance and metabolic disease in adults but may affect young, growing children differently. We investigated the metabolic effects of unpredictable feeding in female juvenile lambs randomly assigned to receive, for six weeks, maintenance feed given twice...

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Autores principales:	Anne L Jaquiery, Mark H Oliver, Nina Landon-Lane, Samuel J Matthews, Jane E Harding, Frank H Bloomfield
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1f7d3086d4bb4796a1c35bc0bb5366f1
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spelling	oai:doaj.org-article:1f7d3086d4bb4796a1c35bc0bb5366f12021-11-18T07:49:22ZUnpredictable feeding impairs glucose tolerance in growing lambs.1932-620310.1371/journal.pone.0061040https://doaj.org/article/1f7d3086d4bb4796a1c35bc0bb5366f12013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23613779/?tool=EBIhttps://doaj.org/toc/1932-6203Irregular eating is associated with insulin resistance and metabolic disease in adults but may affect young, growing children differently. We investigated the metabolic effects of unpredictable feeding in female juvenile lambs randomly assigned to receive, for six weeks, maintenance feed given twice daily in equal portions (Control Group, C; n = 24) or the same weekly feed amount in aliquots of variable size at unpredictable times (Unpredictable Group, U; n = 21). Intravenous glucose tolerance tests (IVGTT), insulin tolerance tests (ITT), and measurement of diurnal plasma cortisol concentrations were performed pre and post the dietary intervention. Groups were compared using t test and RM ANOVA. Weight gain was similar in both groups (C 18 ± 2%; U 16 ± 2% of initial body weight). Glucose area under the curve (AUC) was unchanged in C (AUC pre 818 ± 34, post 801 ± 33 mmol.min.l(-1)), but increased by 20% in U (pre 830 ± 25, post 1010 ± 19 mmol.min.l(-1); p<0.0001), with an inadequate insulin response to glucose load (log(AUC insulin first 40 minutes) post intervention C 1.49 ± 0.04 vs U 1.36 ± 0.04 ng.min.ml(-1); p = 0.03). Insulin tolerance and diurnal variation of plasma cortisol concentrations were not different between groups. Unpredictable feeding impairs insulin response to glucose in growing lambs despite high quality food and normal weight gain. Irregular eating warrants investigation as a potentially remediable risk factor for disordered glucose metabolism.Anne L JaquieryMark H OliverNina Landon-LaneSamuel J MatthewsJane E HardingFrank H BloomfieldPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 4, p e61040 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Anne L Jaquiery Mark H Oliver Nina Landon-Lane Samuel J Matthews Jane E Harding Frank H Bloomfield Unpredictable feeding impairs glucose tolerance in growing lambs.
description	Irregular eating is associated with insulin resistance and metabolic disease in adults but may affect young, growing children differently. We investigated the metabolic effects of unpredictable feeding in female juvenile lambs randomly assigned to receive, for six weeks, maintenance feed given twice daily in equal portions (Control Group, C; n = 24) or the same weekly feed amount in aliquots of variable size at unpredictable times (Unpredictable Group, U; n = 21). Intravenous glucose tolerance tests (IVGTT), insulin tolerance tests (ITT), and measurement of diurnal plasma cortisol concentrations were performed pre and post the dietary intervention. Groups were compared using t test and RM ANOVA. Weight gain was similar in both groups (C 18 ± 2%; U 16 ± 2% of initial body weight). Glucose area under the curve (AUC) was unchanged in C (AUC pre 818 ± 34, post 801 ± 33 mmol.min.l(-1)), but increased by 20% in U (pre 830 ± 25, post 1010 ± 19 mmol.min.l(-1); p<0.0001), with an inadequate insulin response to glucose load (log(AUC insulin first 40 minutes) post intervention C 1.49 ± 0.04 vs U 1.36 ± 0.04 ng.min.ml(-1); p = 0.03). Insulin tolerance and diurnal variation of plasma cortisol concentrations were not different between groups. Unpredictable feeding impairs insulin response to glucose in growing lambs despite high quality food and normal weight gain. Irregular eating warrants investigation as a potentially remediable risk factor for disordered glucose metabolism.
format	article
author	Anne L Jaquiery Mark H Oliver Nina Landon-Lane Samuel J Matthews Jane E Harding Frank H Bloomfield
author_facet	Anne L Jaquiery Mark H Oliver Nina Landon-Lane Samuel J Matthews Jane E Harding Frank H Bloomfield
author_sort	Anne L Jaquiery
title	Unpredictable feeding impairs glucose tolerance in growing lambs.
title_short	Unpredictable feeding impairs glucose tolerance in growing lambs.
title_full	Unpredictable feeding impairs glucose tolerance in growing lambs.
title_fullStr	Unpredictable feeding impairs glucose tolerance in growing lambs.
title_full_unstemmed	Unpredictable feeding impairs glucose tolerance in growing lambs.
title_sort	unpredictable feeding impairs glucose tolerance in growing lambs.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/1f7d3086d4bb4796a1c35bc0bb5366f1
work_keys_str_mv	AT anneljaquiery unpredictablefeedingimpairsglucosetoleranceingrowinglambs AT markholiver unpredictablefeedingimpairsglucosetoleranceingrowinglambs AT ninalandonlane unpredictablefeedingimpairsglucosetoleranceingrowinglambs AT samueljmatthews unpredictablefeedingimpairsglucosetoleranceingrowinglambs AT janeeharding unpredictablefeedingimpairsglucosetoleranceingrowinglambs AT frankhbloomfield unpredictablefeedingimpairsglucosetoleranceingrowinglambs
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Unpredictable feeding impairs glucose tolerance in growing lambs.

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