Serum carotenoids reduce progression of early atherosclerosis in the carotid artery wall among Eastern Finnish men.

<h4>Background</h4>Several previous epidemiologic studies have shown that high blood levels of carotenoids may be protective against early atherosclerosis, but results have been inconsistent. We assessed the association between atherosclerotic progression, measured by intima-media thickn...

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Autores principales:	Jouni Karppi, Sudhir Kurl, Kimmo Ronkainen, Jussi Kauhanen, Jari A Laukkanen
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1f7e14bcd85a440b84b2c9c5940b718f
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spelling	oai:doaj.org-article:1f7e14bcd85a440b84b2c9c5940b718f2021-11-18T07:45:06ZSerum carotenoids reduce progression of early atherosclerosis in the carotid artery wall among Eastern Finnish men.1932-620310.1371/journal.pone.0064107https://doaj.org/article/1f7e14bcd85a440b84b2c9c5940b718f2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23700460/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Several previous epidemiologic studies have shown that high blood levels of carotenoids may be protective against early atherosclerosis, but results have been inconsistent. We assessed the association between atherosclerotic progression, measured by intima-media thickness of the common carotid artery wall, and serum levels of carotenoids.<h4>Methods</h4>We studied the effect of carotenoids on progression of early atherosclerosis in a population-based study. The association between concentrations of serum carotenoids, and intima-media thickness of the common carotid artery wall was explored in 840 middle-aged men (aged 46-65 years) from Eastern Finland. Ultrasonography of the common carotid arteries were performed at baseline and 7-year follow-up. Serum levels of carotenoids were analyzed at baseline. Changes in mean and maximum intima media thickness of carotid artery wall were related to baseline serum carotenoid levels in covariance analyses adjusted for covariates.<h4>Results</h4>In a covariance analysis with adjustment for age, ultrasound sonographer, maximum intima media thickness, examination year, body mass index, systolic blood pressure, smoking, physical activity, serum LDL cholesterol, family history of coronary heart disease, antihypertensive medication and serum high sensitivity C-reactive protein, 7-year change in maximum intima media thickness was inversely associated with lycopene (p = 0.005), α-carotene (p = 0.002) and β-carotene (p = 0.019), respectively.<h4>Conclusions</h4>The present study shows that high serum concentrations of carotenoids may be protective against early atherosclerosis.Jouni KarppiSudhir KurlKimmo RonkainenJussi KauhanenJari A LaukkanenPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 5, p e64107 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jouni Karppi Sudhir Kurl Kimmo Ronkainen Jussi Kauhanen Jari A Laukkanen Serum carotenoids reduce progression of early atherosclerosis in the carotid artery wall among Eastern Finnish men.
description	<h4>Background</h4>Several previous epidemiologic studies have shown that high blood levels of carotenoids may be protective against early atherosclerosis, but results have been inconsistent. We assessed the association between atherosclerotic progression, measured by intima-media thickness of the common carotid artery wall, and serum levels of carotenoids.<h4>Methods</h4>We studied the effect of carotenoids on progression of early atherosclerosis in a population-based study. The association between concentrations of serum carotenoids, and intima-media thickness of the common carotid artery wall was explored in 840 middle-aged men (aged 46-65 years) from Eastern Finland. Ultrasonography of the common carotid arteries were performed at baseline and 7-year follow-up. Serum levels of carotenoids were analyzed at baseline. Changes in mean and maximum intima media thickness of carotid artery wall were related to baseline serum carotenoid levels in covariance analyses adjusted for covariates.<h4>Results</h4>In a covariance analysis with adjustment for age, ultrasound sonographer, maximum intima media thickness, examination year, body mass index, systolic blood pressure, smoking, physical activity, serum LDL cholesterol, family history of coronary heart disease, antihypertensive medication and serum high sensitivity C-reactive protein, 7-year change in maximum intima media thickness was inversely associated with lycopene (p = 0.005), α-carotene (p = 0.002) and β-carotene (p = 0.019), respectively.<h4>Conclusions</h4>The present study shows that high serum concentrations of carotenoids may be protective against early atherosclerosis.
format	article
author	Jouni Karppi Sudhir Kurl Kimmo Ronkainen Jussi Kauhanen Jari A Laukkanen
author_facet	Jouni Karppi Sudhir Kurl Kimmo Ronkainen Jussi Kauhanen Jari A Laukkanen
author_sort	Jouni Karppi
title	Serum carotenoids reduce progression of early atherosclerosis in the carotid artery wall among Eastern Finnish men.
title_short	Serum carotenoids reduce progression of early atherosclerosis in the carotid artery wall among Eastern Finnish men.
title_full	Serum carotenoids reduce progression of early atherosclerosis in the carotid artery wall among Eastern Finnish men.
title_fullStr	Serum carotenoids reduce progression of early atherosclerosis in the carotid artery wall among Eastern Finnish men.
title_full_unstemmed	Serum carotenoids reduce progression of early atherosclerosis in the carotid artery wall among Eastern Finnish men.
title_sort	serum carotenoids reduce progression of early atherosclerosis in the carotid artery wall among eastern finnish men.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/1f7e14bcd85a440b84b2c9c5940b718f
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Serum carotenoids reduce progression of early atherosclerosis in the carotid artery wall among Eastern Finnish men.

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