Essential oil-mediated glycerosomes increase transdermal paeoniflorin delivery: optimization, characterization, and evaluation in vitro and in vivo

Kai Zhang, Yongtai Zhang, Zhe Li, Nana Li, Nianping Feng Department of Pharmaceutical Sciences, School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, People’s Republic of China Abstract: In this study, a novel glycerosome carrier containing essential oils was...

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Autores principales:	Zhang K, Zhang Y, Li Z, Li N, Feng N
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	paeoniflorin transdermal glycerosomes liposomes permeation enhancers essential oil Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/1f81f52485224ae589415337b65c5c7b
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spelling	oai:doaj.org-article:1f81f52485224ae589415337b65c5c7b2021-12-02T03:15:28ZEssential oil-mediated glycerosomes increase transdermal paeoniflorin delivery: optimization, characterization, and evaluation in vitro and in vivo1178-2013https://doaj.org/article/1f81f52485224ae589415337b65c5c7b2017-05-01T00:00:00Zhttps://www.dovepress.com/essential-oil-mediated-glycerosomes-increase-transdermal-paeoniflorin--peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Kai Zhang, Yongtai Zhang, Zhe Li, Nana Li, Nianping Feng Department of Pharmaceutical Sciences, School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, People’s Republic of China Abstract: In this study, a novel glycerosome carrier containing essential oils was prepared for topical administration of paeoniflorin (PF) to enhance its transdermal drug delivery and improve drug absorption in the synovium. The formulation of glycerosomes was optimized by a uniform design, and the final vehicle was composed of 5% (w/v) phospholipid, 0.6% (w/v) cholesterol, and 10% (v/v) glycerol, with 2% (v/v) Speranskia tuberculata essential oil (STO) as the transdermal enhancer. The in vitro transdermal flux of PF loaded in the STO-glycerosomes was 1.4-fold, 1.6-fold, and 1.7-fold higher than those of glycerosomes, liposomes, and tinctures, respectively. In vivo studies showed that the use of STO-glycerosomes was associated with a 3.1-fold greater accumulation of PF in the synovium than that of common glycerosomes. This finding was confirmed by in vivo imaging studies, which found that the fluorescence intensity of Cy5.5-loaded STO-glycerosomes in mice knee joints was 1.8-fold higher than that of the common glycerosomes 5 h after administration. The glycerosomes mediated by STO exhibited considerable skin permeability as well as improved drug absorption in the synovium, indicating that STO-glycerosomes may be a potential PF transdermal delivery vehicle for the treatment of rheumatoid arthritis caused by synovium lesions. Keywords: paeoniflorin, transdermal, glycerosomes, liposomes, permeation enhancers, essential oilZhang KZhang YLi ZLi NFeng NDove Medical Pressarticlepaeoniflorintransdermalglycerosomesliposomespermeation enhancersessential oilMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 12, Pp 3521-3532 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	paeoniflorin transdermal glycerosomes liposomes permeation enhancers essential oil Medicine (General) R5-920
spellingShingle	paeoniflorin transdermal glycerosomes liposomes permeation enhancers essential oil Medicine (General) R5-920 Zhang K Zhang Y Li Z Li N Feng N Essential oil-mediated glycerosomes increase transdermal paeoniflorin delivery: optimization, characterization, and evaluation in vitro and in vivo
description	Kai Zhang, Yongtai Zhang, Zhe Li, Nana Li, Nianping Feng Department of Pharmaceutical Sciences, School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, People’s Republic of China Abstract: In this study, a novel glycerosome carrier containing essential oils was prepared for topical administration of paeoniflorin (PF) to enhance its transdermal drug delivery and improve drug absorption in the synovium. The formulation of glycerosomes was optimized by a uniform design, and the final vehicle was composed of 5% (w/v) phospholipid, 0.6% (w/v) cholesterol, and 10% (v/v) glycerol, with 2% (v/v) Speranskia tuberculata essential oil (STO) as the transdermal enhancer. The in vitro transdermal flux of PF loaded in the STO-glycerosomes was 1.4-fold, 1.6-fold, and 1.7-fold higher than those of glycerosomes, liposomes, and tinctures, respectively. In vivo studies showed that the use of STO-glycerosomes was associated with a 3.1-fold greater accumulation of PF in the synovium than that of common glycerosomes. This finding was confirmed by in vivo imaging studies, which found that the fluorescence intensity of Cy5.5-loaded STO-glycerosomes in mice knee joints was 1.8-fold higher than that of the common glycerosomes 5 h after administration. The glycerosomes mediated by STO exhibited considerable skin permeability as well as improved drug absorption in the synovium, indicating that STO-glycerosomes may be a potential PF transdermal delivery vehicle for the treatment of rheumatoid arthritis caused by synovium lesions. Keywords: paeoniflorin, transdermal, glycerosomes, liposomes, permeation enhancers, essential oil
format	article
author	Zhang K Zhang Y Li Z Li N Feng N
author_facet	Zhang K Zhang Y Li Z Li N Feng N
author_sort	Zhang K
title	Essential oil-mediated glycerosomes increase transdermal paeoniflorin delivery: optimization, characterization, and evaluation in vitro and in vivo
title_short	Essential oil-mediated glycerosomes increase transdermal paeoniflorin delivery: optimization, characterization, and evaluation in vitro and in vivo
title_full	Essential oil-mediated glycerosomes increase transdermal paeoniflorin delivery: optimization, characterization, and evaluation in vitro and in vivo
title_fullStr	Essential oil-mediated glycerosomes increase transdermal paeoniflorin delivery: optimization, characterization, and evaluation in vitro and in vivo
title_full_unstemmed	Essential oil-mediated glycerosomes increase transdermal paeoniflorin delivery: optimization, characterization, and evaluation in vitro and in vivo
title_sort	essential oil-mediated glycerosomes increase transdermal paeoniflorin delivery: optimization, characterization, and evaluation in vitro and in vivo
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/1f81f52485224ae589415337b65c5c7b
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Essential oil-mediated glycerosomes increase transdermal paeoniflorin delivery: optimization, characterization, and evaluation in vitro and in vivo

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