Evaluation of the German biographic screening interview for fetal alcohol spectrum disorder (BSI-FASD)

Abstract Alcohol consumption during pregnancy may lead to permanent damage in the offspring, including fetal alcohol spectrum disorders (FASD), which have an estimated prevalence of 1–8% worldwide. In adulthood, diagnosing FASD is time-consuming and costly. This study aimed to evaluate the discrimin...

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Autores principales:	Michael Widder, Luisa Mierzwa, Lina Schwerg, Henrike Schecke, Johannes Kornhuber, Polyxeni Bouna-Pyrrou, Jan Malte Bumb, Tanja Richter-Schmidinger, Bernd Lenz
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1f83b3d6e16f4f9c9438933308d7e836
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spelling	oai:doaj.org-article:1f83b3d6e16f4f9c9438933308d7e8362021-12-02T13:30:10ZEvaluation of the German biographic screening interview for fetal alcohol spectrum disorder (BSI-FASD)10.1038/s41598-021-83942-22045-2322https://doaj.org/article/1f83b3d6e16f4f9c9438933308d7e8362021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-83942-2https://doaj.org/toc/2045-2322Abstract Alcohol consumption during pregnancy may lead to permanent damage in the offspring, including fetal alcohol spectrum disorders (FASD), which have an estimated prevalence of 1–8% worldwide. In adulthood, diagnosing FASD is time-consuming and costly. This study aimed to evaluate the discriminatory power of a German screening instrument for FASD in adults—the biographic screening interview (BSI-FASD). In an open-label comparative cohort study wherein a one-time survey was administered per participant, we compared 22 subjects with confirmed FASD with control groups of 15 subjects diagnosed with attention deficit hyperactivity disorder (ADHD), 20 subjects with alcohol or opiate dependence, 18 subjects with depression, and 31 controls without prenatal alcohol exposure. The BSI-FASD was found to be resource-efficient, user-friendly, comprehensible, and easily applicable. It provided an overall good convergent and discriminant validity with a sensitivity of 0.77 (adapted 0.86) and specificities between 0.70 and 1.00. The BSI-FASD subdomains differed in their power to differentiate FASD from the groups. This study established that the BSI-FASD is an efficient instrument to screen adults with suspected FASD. The BSI-FASD may facilitate future diagnostic evaluation and thereby contribute to improved treatment of affected individuals.Michael WidderLuisa MierzwaLina SchwergHenrike ScheckeJohannes KornhuberPolyxeni Bouna-PyrrouJan Malte BumbTanja Richter-SchmidingerBernd LenzNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Michael Widder Luisa Mierzwa Lina Schwerg Henrike Schecke Johannes Kornhuber Polyxeni Bouna-Pyrrou Jan Malte Bumb Tanja Richter-Schmidinger Bernd Lenz Evaluation of the German biographic screening interview for fetal alcohol spectrum disorder (BSI-FASD)
description	Abstract Alcohol consumption during pregnancy may lead to permanent damage in the offspring, including fetal alcohol spectrum disorders (FASD), which have an estimated prevalence of 1–8% worldwide. In adulthood, diagnosing FASD is time-consuming and costly. This study aimed to evaluate the discriminatory power of a German screening instrument for FASD in adults—the biographic screening interview (BSI-FASD). In an open-label comparative cohort study wherein a one-time survey was administered per participant, we compared 22 subjects with confirmed FASD with control groups of 15 subjects diagnosed with attention deficit hyperactivity disorder (ADHD), 20 subjects with alcohol or opiate dependence, 18 subjects with depression, and 31 controls without prenatal alcohol exposure. The BSI-FASD was found to be resource-efficient, user-friendly, comprehensible, and easily applicable. It provided an overall good convergent and discriminant validity with a sensitivity of 0.77 (adapted 0.86) and specificities between 0.70 and 1.00. The BSI-FASD subdomains differed in their power to differentiate FASD from the groups. This study established that the BSI-FASD is an efficient instrument to screen adults with suspected FASD. The BSI-FASD may facilitate future diagnostic evaluation and thereby contribute to improved treatment of affected individuals.
format	article
author	Michael Widder Luisa Mierzwa Lina Schwerg Henrike Schecke Johannes Kornhuber Polyxeni Bouna-Pyrrou Jan Malte Bumb Tanja Richter-Schmidinger Bernd Lenz
author_facet	Michael Widder Luisa Mierzwa Lina Schwerg Henrike Schecke Johannes Kornhuber Polyxeni Bouna-Pyrrou Jan Malte Bumb Tanja Richter-Schmidinger Bernd Lenz
author_sort	Michael Widder
title	Evaluation of the German biographic screening interview for fetal alcohol spectrum disorder (BSI-FASD)
title_short	Evaluation of the German biographic screening interview for fetal alcohol spectrum disorder (BSI-FASD)
title_full	Evaluation of the German biographic screening interview for fetal alcohol spectrum disorder (BSI-FASD)
title_fullStr	Evaluation of the German biographic screening interview for fetal alcohol spectrum disorder (BSI-FASD)
title_full_unstemmed	Evaluation of the German biographic screening interview for fetal alcohol spectrum disorder (BSI-FASD)
title_sort	evaluation of the german biographic screening interview for fetal alcohol spectrum disorder (bsi-fasd)
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/1f83b3d6e16f4f9c9438933308d7e836
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Evaluation of the German biographic screening interview for fetal alcohol spectrum disorder (BSI-FASD)

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