Estrogen receptor variant ERα46 and insulin receptor drive in primary breast cancer cells growth effects and interleukin 11 induction prompting the motility of cancer‐associated fibroblasts

Estrogen receptor variant ERα46 and insulin receptor drive in primary breast cancer cells growth effects and interleukin 11 induction prompting the motility of cancer‐associated fibroblasts

Abstract Among the prognostic and predictive biomarkers of breast cancer (BC), the role of estrogen receptor (ER)α wild‐type has been acknowledged, although the action of certain ERα splice variants has not been elucidated. Insulin/insulin receptor (IR) axis has also been involved in the progression...

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Bibliographic Details
Main Authors: Francesca Cirillo, Michele Pellegrino, Marianna Talia, Ida Daniela Perrotta, Damiano Cosimo Rigiracciolo, Asia Spinelli, Domenica Scordamaglia, Lucia Muglia, Rita Guzzi, Anna Maria Miglietta, Ernestina Marianna De Francesco, Antonino Belfiore, Marcello Maggiolini, Rosamaria Lappano
Format: article
Language:EN
Published: Wiley 2021
Subjects:
breast cancer
ERα46
estrogens
insulin
insulin receptor
Medicine (General)
R5-920
Online Access:https://doaj.org/article/1f8643db7ad8465e9ea13f2b11edef84
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https://doaj.org/article/1f8643db7ad8465e9ea13f2b11edef84

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