Abnormal regional spontaneous neural activity in visual pathway in retinal detachment patients: a resting-state functional MRI study

Xin Huang,1,2,* Dan Li,3,* Hai-Jun Li,3 Yu-Lin Zhong,1 Shelby Freeberg,4 Jing Bao,1 Xian-Jun Zeng,3 Yi Shao1 1Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Jiangxi Province Clinical Ophthalmology Institute, Nanchang, Jiangxi, People’s Republic of China...

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Autores principales:	Huang X, Li D, Li H, Zhong Y, Freeberg S, Bao J, Zeng X, Shao Y
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	Retinal detachment Regional homogeneity Resting state Functional magnetic resonance imaging Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/1f864924b77a42eaa3e5250a118525af
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spelling	oai:doaj.org-article:1f864924b77a42eaa3e5250a118525af2021-12-02T03:14:04ZAbnormal regional spontaneous neural activity in visual pathway in retinal detachment patients: a resting-state functional MRI study1178-2021https://doaj.org/article/1f864924b77a42eaa3e5250a118525af2017-11-01T00:00:00Zhttps://www.dovepress.com/abnormal-regional-spontaneous-neural-activity-in-visual-pathway-in-ret-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Xin Huang,1,2,* Dan Li,3,* Hai-Jun Li,3 Yu-Lin Zhong,1 Shelby Freeberg,4 Jing Bao,1 Xian-Jun Zeng,3 Yi Shao1 1Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Jiangxi Province Clinical Ophthalmology Institute, Nanchang, Jiangxi, People’s Republic of China; 2Department of Ophthalmology, Eye Center, Renmin Hospital of Wuhan University, Wuhan University, Wuhan, Hubei, People’s Republic of China; 3Department of Radiology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, People’s Republic of China; 4Department of Ophthalmology, University of Florida, Gainesville, FL, USA *These authors contributed equally to this work Objective: The aim of the study was to investigate changes of brain neural homogeneity in retinal detachment (RD) patients using the regional homogeneity (ReHo) method to understand their relationships with clinical features. Materials and methods: A total of 30 patients with RD (16 men and 14 women), and 30 healthy controls (HCs) (16 men and 14 women) closely matched in age and sex were recruited. Resting-state functional magnetic resonance imaging scans were performed for all subjects. The ReHo method was used to investigate the brain regional neural homogeneity. Patients with RD were distinguished from HCs by receiver operating characteristic curve. The relationships between the mean ReHo signal values in many brain regions and clinical features in RD patients were calculated by Pearson correlation analysis. Results: Compared with HCs, RD patients had significantly decreased ReHo values in the right occipital lobe, right superior temporal gyrus, bilateral cuneus and left middle frontal gyrus. Moreover, we found that the mean ReHo signal of the bilateral cuneus showed positive relationships with the duration of the RD (r=0.392, P=0.032). Conclusion: The RD patients showed brain neural homogeneity dysfunction in the visual pathway, which may underline the pathological mechanism of RD patients with acute vision loss. Besides, the ReHo values can reflect the progress of the RD disease. Keywords: retinal detachment, neural regional homogeneity, resting state, functional magnetic resonance imagingHuang XLi DLi HZhong YFreeberg SBao JZeng XShao YDove Medical PressarticleRetinal detachmentRegional homogeneityResting stateFunctional magnetic resonance imagingNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 13, Pp 2849-2854 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Retinal detachment Regional homogeneity Resting state Functional magnetic resonance imaging Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Retinal detachment Regional homogeneity Resting state Functional magnetic resonance imaging Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Huang X Li D Li H Zhong Y Freeberg S Bao J Zeng X Shao Y Abnormal regional spontaneous neural activity in visual pathway in retinal detachment patients: a resting-state functional MRI study
description	Xin Huang,1,2,* Dan Li,3,* Hai-Jun Li,3 Yu-Lin Zhong,1 Shelby Freeberg,4 Jing Bao,1 Xian-Jun Zeng,3 Yi Shao1 1Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Jiangxi Province Clinical Ophthalmology Institute, Nanchang, Jiangxi, People’s Republic of China; 2Department of Ophthalmology, Eye Center, Renmin Hospital of Wuhan University, Wuhan University, Wuhan, Hubei, People’s Republic of China; 3Department of Radiology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, People’s Republic of China; 4Department of Ophthalmology, University of Florida, Gainesville, FL, USA *These authors contributed equally to this work Objective: The aim of the study was to investigate changes of brain neural homogeneity in retinal detachment (RD) patients using the regional homogeneity (ReHo) method to understand their relationships with clinical features. Materials and methods: A total of 30 patients with RD (16 men and 14 women), and 30 healthy controls (HCs) (16 men and 14 women) closely matched in age and sex were recruited. Resting-state functional magnetic resonance imaging scans were performed for all subjects. The ReHo method was used to investigate the brain regional neural homogeneity. Patients with RD were distinguished from HCs by receiver operating characteristic curve. The relationships between the mean ReHo signal values in many brain regions and clinical features in RD patients were calculated by Pearson correlation analysis. Results: Compared with HCs, RD patients had significantly decreased ReHo values in the right occipital lobe, right superior temporal gyrus, bilateral cuneus and left middle frontal gyrus. Moreover, we found that the mean ReHo signal of the bilateral cuneus showed positive relationships with the duration of the RD (r=0.392, P=0.032). Conclusion: The RD patients showed brain neural homogeneity dysfunction in the visual pathway, which may underline the pathological mechanism of RD patients with acute vision loss. Besides, the ReHo values can reflect the progress of the RD disease. Keywords: retinal detachment, neural regional homogeneity, resting state, functional magnetic resonance imaging
format	article
author	Huang X Li D Li H Zhong Y Freeberg S Bao J Zeng X Shao Y
author_facet	Huang X Li D Li H Zhong Y Freeberg S Bao J Zeng X Shao Y
author_sort	Huang X
title	Abnormal regional spontaneous neural activity in visual pathway in retinal detachment patients: a resting-state functional MRI study
title_short	Abnormal regional spontaneous neural activity in visual pathway in retinal detachment patients: a resting-state functional MRI study
title_full	Abnormal regional spontaneous neural activity in visual pathway in retinal detachment patients: a resting-state functional MRI study
title_fullStr	Abnormal regional spontaneous neural activity in visual pathway in retinal detachment patients: a resting-state functional MRI study
title_full_unstemmed	Abnormal regional spontaneous neural activity in visual pathway in retinal detachment patients: a resting-state functional MRI study
title_sort	abnormal regional spontaneous neural activity in visual pathway in retinal detachment patients: a resting-state functional mri study
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/1f864924b77a42eaa3e5250a118525af
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Abnormal regional spontaneous neural activity in visual pathway in retinal detachment patients: a resting-state functional MRI study

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