Association between thyroid hormones and insulin resistance indices based on the Korean National Health and Nutrition Examination Survey

Abstract Thyroid dysfunction has been implicated as a potential pathophysiological factor in glucose homeostasis and insulin resistance (IR). This study aimed to identify the correlation between thyroid dysfunction and IR. We used data from the sixth Korean National Health and Nutrition Examination...

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Autores principales:	Yun Mi Choi, Min Kyung Kim, Mi Kyung Kwak, Dooman Kim, Eun-Gyoung Hong
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1f874ae5df1947bc8f5d1cccddce6884
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spelling	oai:doaj.org-article:1f874ae5df1947bc8f5d1cccddce68842021-11-08T10:50:40ZAssociation between thyroid hormones and insulin resistance indices based on the Korean National Health and Nutrition Examination Survey10.1038/s41598-021-01101-z2045-2322https://doaj.org/article/1f874ae5df1947bc8f5d1cccddce68842021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-01101-zhttps://doaj.org/toc/2045-2322Abstract Thyroid dysfunction has been implicated as a potential pathophysiological factor in glucose homeostasis and insulin resistance (IR). This study aimed to identify the correlation between thyroid dysfunction and IR. We used data from the sixth Korean National Health and Nutrition Examination Survey to evaluate a total of 5727 participants. The triglyceride glucose (TyG) index and homeostasis model assessment of insulin resistance (HOMA-IR) were calculated to represent IR. Correlation analysis was performed between thyroid dysfunction and IR. The log-transformed TSH (LnTSH) and free T4 were significantly correlated with the TyG index (TSH, beta coefficient 0.025, 95% confidence interval [CI] 0.014–0.036, p < 0.001; free T4, − 0.110 (− 0.166 to − 0.054), p < 0.001) but not HOMA-IR. Overt hypothyroidism is correlated with increased TyG index in pre-menopausal females (0.215 (0.122–0.309) p < 0.001). On the other hand, overt hyperthyroidism is correlated with increased HOMA-IR in males (0.304 (0.193–0.416), p < 0.001) and post-menopausal females (1.812 (1.717–1.907), p < 0.001). In euthyroid subjects, LnTSH and TyG index were significantly correlated in females. In conclusion, both hyperthyroidism and hypothyroidism might be associated with IR but by different mechanisms. It might be helpful to assess IR with appropriate indexes in patients with thyroid dysfunction.Yun Mi ChoiMin Kyung KimMi Kyung KwakDooman KimEun-Gyoung HongNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yun Mi Choi Min Kyung Kim Mi Kyung Kwak Dooman Kim Eun-Gyoung Hong Association between thyroid hormones and insulin resistance indices based on the Korean National Health and Nutrition Examination Survey
description	Abstract Thyroid dysfunction has been implicated as a potential pathophysiological factor in glucose homeostasis and insulin resistance (IR). This study aimed to identify the correlation between thyroid dysfunction and IR. We used data from the sixth Korean National Health and Nutrition Examination Survey to evaluate a total of 5727 participants. The triglyceride glucose (TyG) index and homeostasis model assessment of insulin resistance (HOMA-IR) were calculated to represent IR. Correlation analysis was performed between thyroid dysfunction and IR. The log-transformed TSH (LnTSH) and free T4 were significantly correlated with the TyG index (TSH, beta coefficient 0.025, 95% confidence interval [CI] 0.014–0.036, p < 0.001; free T4, − 0.110 (− 0.166 to − 0.054), p < 0.001) but not HOMA-IR. Overt hypothyroidism is correlated with increased TyG index in pre-menopausal females (0.215 (0.122–0.309) p < 0.001). On the other hand, overt hyperthyroidism is correlated with increased HOMA-IR in males (0.304 (0.193–0.416), p < 0.001) and post-menopausal females (1.812 (1.717–1.907), p < 0.001). In euthyroid subjects, LnTSH and TyG index were significantly correlated in females. In conclusion, both hyperthyroidism and hypothyroidism might be associated with IR but by different mechanisms. It might be helpful to assess IR with appropriate indexes in patients with thyroid dysfunction.
format	article
author	Yun Mi Choi Min Kyung Kim Mi Kyung Kwak Dooman Kim Eun-Gyoung Hong
author_facet	Yun Mi Choi Min Kyung Kim Mi Kyung Kwak Dooman Kim Eun-Gyoung Hong
author_sort	Yun Mi Choi
title	Association between thyroid hormones and insulin resistance indices based on the Korean National Health and Nutrition Examination Survey
title_short	Association between thyroid hormones and insulin resistance indices based on the Korean National Health and Nutrition Examination Survey
title_full	Association between thyroid hormones and insulin resistance indices based on the Korean National Health and Nutrition Examination Survey
title_fullStr	Association between thyroid hormones and insulin resistance indices based on the Korean National Health and Nutrition Examination Survey
title_full_unstemmed	Association between thyroid hormones and insulin resistance indices based on the Korean National Health and Nutrition Examination Survey
title_sort	association between thyroid hormones and insulin resistance indices based on the korean national health and nutrition examination survey
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/1f874ae5df1947bc8f5d1cccddce6884
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Association between thyroid hormones and insulin resistance indices based on the Korean National Health and Nutrition Examination Survey

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