Unique properties of a subset of human pluripotent stem cells with high capacity for self-renewal

Human pluripotent cells (hPSCs) in standard culture are similar to mouse epiblast cells, but heterogeneity within hPSC cultures complicates comparisons. Here the authors show that a subpopulation of hPSCs enriched for self-renewal capacity have distinct cell cycle, metabolic, DNA methylation, and AT...

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Autores principales:	Kevin X. Lau, Elizabeth A. Mason, Joshua Kie, David P. De Souza, Joachim Kloehn, Dedreia Tull, Malcolm J. McConville, Andrew Keniry, Tamara Beck, Marnie E. Blewitt, Matthew E. Ritchie, Shalin H. Naik, Daniela Zalcenstein, Othmar Korn, Shian Su, Irene Gallego Romero, Catrina Spruce, Christopher L. Baker, Tracy C. McGarr, Christine A. Wells, Martin F. Pera
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1f87c566710a45a38bb6a81fc0b27bcc
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spelling	oai:doaj.org-article:1f87c566710a45a38bb6a81fc0b27bcc2021-12-02T15:43:16ZUnique properties of a subset of human pluripotent stem cells with high capacity for self-renewal10.1038/s41467-020-16214-82041-1723https://doaj.org/article/1f87c566710a45a38bb6a81fc0b27bcc2020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16214-8https://doaj.org/toc/2041-1723Human pluripotent cells (hPSCs) in standard culture are similar to mouse epiblast cells, but heterogeneity within hPSC cultures complicates comparisons. Here the authors show that a subpopulation of hPSCs enriched for self-renewal capacity have distinct cell cycle, metabolic, DNA methylation, and ATAC-seq profiles.Kevin X. LauElizabeth A. MasonJoshua KieDavid P. De SouzaJoachim KloehnDedreia TullMalcolm J. McConvilleAndrew KeniryTamara BeckMarnie E. BlewittMatthew E. RitchieShalin H. NaikDaniela ZalcensteinOthmar KornShian SuIrene Gallego RomeroCatrina SpruceChristopher L. BakerTracy C. McGarrChristine A. WellsMartin F. PeraNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kevin X. Lau Elizabeth A. Mason Joshua Kie David P. De Souza Joachim Kloehn Dedreia Tull Malcolm J. McConville Andrew Keniry Tamara Beck Marnie E. Blewitt Matthew E. Ritchie Shalin H. Naik Daniela Zalcenstein Othmar Korn Shian Su Irene Gallego Romero Catrina Spruce Christopher L. Baker Tracy C. McGarr Christine A. Wells Martin F. Pera Unique properties of a subset of human pluripotent stem cells with high capacity for self-renewal
description	Human pluripotent cells (hPSCs) in standard culture are similar to mouse epiblast cells, but heterogeneity within hPSC cultures complicates comparisons. Here the authors show that a subpopulation of hPSCs enriched for self-renewal capacity have distinct cell cycle, metabolic, DNA methylation, and ATAC-seq profiles.
format	article
author	Kevin X. Lau Elizabeth A. Mason Joshua Kie David P. De Souza Joachim Kloehn Dedreia Tull Malcolm J. McConville Andrew Keniry Tamara Beck Marnie E. Blewitt Matthew E. Ritchie Shalin H. Naik Daniela Zalcenstein Othmar Korn Shian Su Irene Gallego Romero Catrina Spruce Christopher L. Baker Tracy C. McGarr Christine A. Wells Martin F. Pera
author_facet	Kevin X. Lau Elizabeth A. Mason Joshua Kie David P. De Souza Joachim Kloehn Dedreia Tull Malcolm J. McConville Andrew Keniry Tamara Beck Marnie E. Blewitt Matthew E. Ritchie Shalin H. Naik Daniela Zalcenstein Othmar Korn Shian Su Irene Gallego Romero Catrina Spruce Christopher L. Baker Tracy C. McGarr Christine A. Wells Martin F. Pera
author_sort	Kevin X. Lau
title	Unique properties of a subset of human pluripotent stem cells with high capacity for self-renewal
title_short	Unique properties of a subset of human pluripotent stem cells with high capacity for self-renewal
title_full	Unique properties of a subset of human pluripotent stem cells with high capacity for self-renewal
title_fullStr	Unique properties of a subset of human pluripotent stem cells with high capacity for self-renewal
title_full_unstemmed	Unique properties of a subset of human pluripotent stem cells with high capacity for self-renewal
title_sort	unique properties of a subset of human pluripotent stem cells with high capacity for self-renewal
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/1f87c566710a45a38bb6a81fc0b27bcc
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Unique properties of a subset of human pluripotent stem cells with high capacity for self-renewal

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