Distal axotomy enhances retrograde presynaptic excitability onto injured pyramidal neurons via trans-synaptic signaling

Spinal cord injury can induce synaptic reorganization and remodeling in the brain. Here the authors study how severed distal axons signal back to the cell body to induce hyperexcitability, loss of inhibition and enhanced presynaptic release through netrin-1.

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Autores principales:	Tharkika Nagendran, Rylan S. Larsen, Rebecca L. Bigler, Shawn B. Frost, Benjamin D. Philpot, Randolph J. Nudo, Anne Marion Taylor
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1f87dabee91b461a89a2e1999bf53396
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spelling	oai:doaj.org-article:1f87dabee91b461a89a2e1999bf533962021-12-02T15:38:56ZDistal axotomy enhances retrograde presynaptic excitability onto injured pyramidal neurons via trans-synaptic signaling10.1038/s41467-017-00652-y2041-1723https://doaj.org/article/1f87dabee91b461a89a2e1999bf533962017-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00652-yhttps://doaj.org/toc/2041-1723Spinal cord injury can induce synaptic reorganization and remodeling in the brain. Here the authors study how severed distal axons signal back to the cell body to induce hyperexcitability, loss of inhibition and enhanced presynaptic release through netrin-1.Tharkika NagendranRylan S. LarsenRebecca L. BiglerShawn B. FrostBenjamin D. PhilpotRandolph J. NudoAnne Marion TaylorNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Tharkika Nagendran Rylan S. Larsen Rebecca L. Bigler Shawn B. Frost Benjamin D. Philpot Randolph J. Nudo Anne Marion Taylor Distal axotomy enhances retrograde presynaptic excitability onto injured pyramidal neurons via trans-synaptic signaling
description	Spinal cord injury can induce synaptic reorganization and remodeling in the brain. Here the authors study how severed distal axons signal back to the cell body to induce hyperexcitability, loss of inhibition and enhanced presynaptic release through netrin-1.
format	article
author	Tharkika Nagendran Rylan S. Larsen Rebecca L. Bigler Shawn B. Frost Benjamin D. Philpot Randolph J. Nudo Anne Marion Taylor
author_facet	Tharkika Nagendran Rylan S. Larsen Rebecca L. Bigler Shawn B. Frost Benjamin D. Philpot Randolph J. Nudo Anne Marion Taylor
author_sort	Tharkika Nagendran
title	Distal axotomy enhances retrograde presynaptic excitability onto injured pyramidal neurons via trans-synaptic signaling
title_short	Distal axotomy enhances retrograde presynaptic excitability onto injured pyramidal neurons via trans-synaptic signaling
title_full	Distal axotomy enhances retrograde presynaptic excitability onto injured pyramidal neurons via trans-synaptic signaling
title_fullStr	Distal axotomy enhances retrograde presynaptic excitability onto injured pyramidal neurons via trans-synaptic signaling
title_full_unstemmed	Distal axotomy enhances retrograde presynaptic excitability onto injured pyramidal neurons via trans-synaptic signaling
title_sort	distal axotomy enhances retrograde presynaptic excitability onto injured pyramidal neurons via trans-synaptic signaling
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/1f87dabee91b461a89a2e1999bf53396
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Distal axotomy enhances retrograde presynaptic excitability onto injured pyramidal neurons via trans-synaptic signaling

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