Biofilms in chronic rhinosinusitis: Pathophysiology and therapeutic strategies

Background: There is increasing evidence that biofilms are critical to the pathophysiology of chronic infections including chronic rhinosinusitis (CRS). Until relatively recently, our understanding of biofilms was limited. Recent advances in methods for biofilm identification and molecular biology h...

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Autores principales:	Judd H. Fastenberg, Wayne D. Hsueh, Ali Mustafa, Nadeem A. Akbar, Waleed M. Abuzeid
Formato:	article
Lenguaje:	EN
Publicado:	KeAi Communications Co., Ltd. 2016
Materias:	Otorhinolaryngology RF1-547 Surgery RD1-811
Acceso en línea:	https://doaj.org/article/1f88e4a5eeaf473ca3e83bed2e192382
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spelling	oai:doaj.org-article:1f88e4a5eeaf473ca3e83bed2e1923822021-12-02T14:20:55ZBiofilms in chronic rhinosinusitis: Pathophysiology and therapeutic strategies2095-881110.1016/j.wjorl.2016.03.002https://doaj.org/article/1f88e4a5eeaf473ca3e83bed2e1923822016-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S209588111630004Xhttps://doaj.org/toc/2095-8811Background: There is increasing evidence that biofilms are critical to the pathophysiology of chronic infections including chronic rhinosinusitis (CRS). Until relatively recently, our understanding of biofilms was limited. Recent advances in methods for biofilm identification and molecular biology have offered new insights into the role of biofilms in CRS. With these insights, investigators have begun to investigate novel therapeutic strategies that may disrupt or eradicate biofilms in CRS. Objective: This review seeks to explore the evidence implicating biofilms in CRS, discuss potential anti-biofilm therapeutic strategies, and suggest future directions for research. Results: The existing evidence strongly supports the role of biofilms in the pathogenesis of CRS. Several anti-biofilm therapies have been investigated for use in CRS and these are at variable stages of development. Generally, these strategies: 1) neutralize biofilm microbes; 2) disperse existing biofilms; or 3) disrupt quorum sensing. Several of the most promising anti-biofilm therapeutic strategies are reviewed. Conclusions: A better understanding of biofilm function and their contribution to the CRS disease process will be pivotal to the development of novel treatments that may augment and, potentially, redefine the CRS treatment paradigm. There is tremendous potential for future research. Keywords: Sinusitis, Biofilms, Anti-bacterial agents, Quorum sensing, Surface-active agents, Active immune response, Innate immune responseJudd H. FastenbergWayne D. HsuehAli MustafaNadeem A. AkbarWaleed M. AbuzeidKeAi Communications Co., Ltd.articleOtorhinolaryngologyRF1-547SurgeryRD1-811ENWorld Journal of Otorhinolaryngology-Head and Neck Surgery, Vol 2, Iss 4, Pp 219-229 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Otorhinolaryngology RF1-547 Surgery RD1-811
spellingShingle	Otorhinolaryngology RF1-547 Surgery RD1-811 Judd H. Fastenberg Wayne D. Hsueh Ali Mustafa Nadeem A. Akbar Waleed M. Abuzeid Biofilms in chronic rhinosinusitis: Pathophysiology and therapeutic strategies
description	Background: There is increasing evidence that biofilms are critical to the pathophysiology of chronic infections including chronic rhinosinusitis (CRS). Until relatively recently, our understanding of biofilms was limited. Recent advances in methods for biofilm identification and molecular biology have offered new insights into the role of biofilms in CRS. With these insights, investigators have begun to investigate novel therapeutic strategies that may disrupt or eradicate biofilms in CRS. Objective: This review seeks to explore the evidence implicating biofilms in CRS, discuss potential anti-biofilm therapeutic strategies, and suggest future directions for research. Results: The existing evidence strongly supports the role of biofilms in the pathogenesis of CRS. Several anti-biofilm therapies have been investigated for use in CRS and these are at variable stages of development. Generally, these strategies: 1) neutralize biofilm microbes; 2) disperse existing biofilms; or 3) disrupt quorum sensing. Several of the most promising anti-biofilm therapeutic strategies are reviewed. Conclusions: A better understanding of biofilm function and their contribution to the CRS disease process will be pivotal to the development of novel treatments that may augment and, potentially, redefine the CRS treatment paradigm. There is tremendous potential for future research. Keywords: Sinusitis, Biofilms, Anti-bacterial agents, Quorum sensing, Surface-active agents, Active immune response, Innate immune response
format	article
author	Judd H. Fastenberg Wayne D. Hsueh Ali Mustafa Nadeem A. Akbar Waleed M. Abuzeid
author_facet	Judd H. Fastenberg Wayne D. Hsueh Ali Mustafa Nadeem A. Akbar Waleed M. Abuzeid
author_sort	Judd H. Fastenberg
title	Biofilms in chronic rhinosinusitis: Pathophysiology and therapeutic strategies
title_short	Biofilms in chronic rhinosinusitis: Pathophysiology and therapeutic strategies
title_full	Biofilms in chronic rhinosinusitis: Pathophysiology and therapeutic strategies
title_fullStr	Biofilms in chronic rhinosinusitis: Pathophysiology and therapeutic strategies
title_full_unstemmed	Biofilms in chronic rhinosinusitis: Pathophysiology and therapeutic strategies
title_sort	biofilms in chronic rhinosinusitis: pathophysiology and therapeutic strategies
publisher	KeAi Communications Co., Ltd.
publishDate	2016
url	https://doaj.org/article/1f88e4a5eeaf473ca3e83bed2e192382
work_keys_str_mv	AT juddhfastenberg biofilmsinchronicrhinosinusitispathophysiologyandtherapeuticstrategies AT waynedhsueh biofilmsinchronicrhinosinusitispathophysiologyandtherapeuticstrategies AT alimustafa biofilmsinchronicrhinosinusitispathophysiologyandtherapeuticstrategies AT nadeemaakbar biofilmsinchronicrhinosinusitispathophysiologyandtherapeuticstrategies AT waleedmabuzeid biofilmsinchronicrhinosinusitispathophysiologyandtherapeuticstrategies
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Biofilms in chronic rhinosinusitis: Pathophysiology and therapeutic strategies

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