Circulating miR-92b and miR-375 for monitoring the chemoresistance and prognosis of small cell lung cancer

Abstract miRNAs have been reported to be stably detectable in plasma and to function as potent biomarkers in multiple cancers. The study aimed to evaluate the expression of candidate circulating miRNAs in patients with small cell lung cancer (SCLC) to identify potential noninvasive biomarkers. The e...

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Autores principales:	Ming Li, Wulin Shan, Bo Hong, Jinglu Zou, Hong Li, Dandan Han, Yang Zhang, Lailing Li, Dan Li, Wenchu Lin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1f8aaa273f794949b3eae5d37a2d27db
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spelling	oai:doaj.org-article:1f8aaa273f794949b3eae5d37a2d27db2021-12-02T16:06:40ZCirculating miR-92b and miR-375 for monitoring the chemoresistance and prognosis of small cell lung cancer10.1038/s41598-020-69615-62045-2322https://doaj.org/article/1f8aaa273f794949b3eae5d37a2d27db2020-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-69615-6https://doaj.org/toc/2045-2322Abstract miRNAs have been reported to be stably detectable in plasma and to function as potent biomarkers in multiple cancers. The study aimed to evaluate the expression of candidate circulating miRNAs in patients with small cell lung cancer (SCLC) to identify potential noninvasive biomarkers. The expression of five miRNAs (miR-92b, miR-146a, miR-375, miR-1224, and miR-1246) was significantly upregulated in plasma after chemoresistance induction. Receiver operating characteristic curve (ROC) analysis showed that the area under the curve (AUC) values of miR-92b and miR-375 were 0.766 and 0.791, respectively. The data demonstrated that among the five miRNAs assessed, these two miRNAs had better diagnostic accuracy for monitoring drug resistance. In addition, miR-92b and miR-375 levels were decreased after effective chemotherapy. Furthermore, Kaplan–Meier survival analysis confirmed that high expression of miR-92b and miR-375 was closely related to shorter progression-free survival (PFS) in SCLC patients. In conclusion, these findings indicate that circulating miR-92b and miR-375 might be ideal noninvasive biomarkers for monitoring drug resistance during chemotherapy and evaluating the prognosis of patients with SCLC.Ming LiWulin ShanBo HongJinglu ZouHong LiDandan HanYang ZhangLailing LiDan LiWenchu LinNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ming Li Wulin Shan Bo Hong Jinglu Zou Hong Li Dandan Han Yang Zhang Lailing Li Dan Li Wenchu Lin Circulating miR-92b and miR-375 for monitoring the chemoresistance and prognosis of small cell lung cancer
description	Abstract miRNAs have been reported to be stably detectable in plasma and to function as potent biomarkers in multiple cancers. The study aimed to evaluate the expression of candidate circulating miRNAs in patients with small cell lung cancer (SCLC) to identify potential noninvasive biomarkers. The expression of five miRNAs (miR-92b, miR-146a, miR-375, miR-1224, and miR-1246) was significantly upregulated in plasma after chemoresistance induction. Receiver operating characteristic curve (ROC) analysis showed that the area under the curve (AUC) values of miR-92b and miR-375 were 0.766 and 0.791, respectively. The data demonstrated that among the five miRNAs assessed, these two miRNAs had better diagnostic accuracy for monitoring drug resistance. In addition, miR-92b and miR-375 levels were decreased after effective chemotherapy. Furthermore, Kaplan–Meier survival analysis confirmed that high expression of miR-92b and miR-375 was closely related to shorter progression-free survival (PFS) in SCLC patients. In conclusion, these findings indicate that circulating miR-92b and miR-375 might be ideal noninvasive biomarkers for monitoring drug resistance during chemotherapy and evaluating the prognosis of patients with SCLC.
format	article
author	Ming Li Wulin Shan Bo Hong Jinglu Zou Hong Li Dandan Han Yang Zhang Lailing Li Dan Li Wenchu Lin
author_facet	Ming Li Wulin Shan Bo Hong Jinglu Zou Hong Li Dandan Han Yang Zhang Lailing Li Dan Li Wenchu Lin
author_sort	Ming Li
title	Circulating miR-92b and miR-375 for monitoring the chemoresistance and prognosis of small cell lung cancer
title_short	Circulating miR-92b and miR-375 for monitoring the chemoresistance and prognosis of small cell lung cancer
title_full	Circulating miR-92b and miR-375 for monitoring the chemoresistance and prognosis of small cell lung cancer
title_fullStr	Circulating miR-92b and miR-375 for monitoring the chemoresistance and prognosis of small cell lung cancer
title_full_unstemmed	Circulating miR-92b and miR-375 for monitoring the chemoresistance and prognosis of small cell lung cancer
title_sort	circulating mir-92b and mir-375 for monitoring the chemoresistance and prognosis of small cell lung cancer
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/1f8aaa273f794949b3eae5d37a2d27db
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Circulating miR-92b and miR-375 for monitoring the chemoresistance and prognosis of small cell lung cancer

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