CD4+CD25+ Regulatory T cell ontogeny and preferential migration to the cecal tonsils in chickens.

Thymic CD4(+)CD25(+) cells have regulatory-T-cell-like properties in chickens. This study examined the ontogeny of CD4(+)CD25(+) cells in the thymus and in peripheral compartments in chickens. CD4(+)CD25(+) cells started to appear in the thymus at day 15 of incubation (E15), although at low percenta...

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Autores principales:	Revathi Shanmugasundaram, Ramesh K Selvaraj
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1f9002c43ac94405a4810126db8e5644
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spelling	oai:doaj.org-article:1f9002c43ac94405a4810126db8e56442021-11-18T07:24:13ZCD4+CD25+ Regulatory T cell ontogeny and preferential migration to the cecal tonsils in chickens.1932-620310.1371/journal.pone.0033970https://doaj.org/article/1f9002c43ac94405a4810126db8e56442012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22479489/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Thymic CD4(+)CD25(+) cells have regulatory-T-cell-like properties in chickens. This study examined the ontogeny of CD4(+)CD25(+) cells in the thymus and in peripheral compartments in chickens. CD4(+)CD25(+) cells started to appear in the thymus at day 15 of incubation (E15), although at low percentages. Expressed as a percentage of CD4(+) cells, CD4(+)CD25(+) cells increased (P<0.01) from 1.7% at E20 to 7.3% at 0 d post-hatch (D0). CD4(+)CD25(+) cells did not appear in the spleen or cecal tonsils of embryos. Expressed as a percentage of CD4(+) cells, CD4(+)CD25(+) cells increased (P<0.01) from 0% at D0 to 27% at D1 in cecal tonsils and from 0% at D0 to 11% at D1 in the spleen. Expressed as a percentage of all mononuclear cells, cecal tonsils at D1 had approximately 3.5-fold higher percentage of CD4(+)CD25(+) cells than the spleen at D1. CD4(+)CD25(+) cells from cecal tonsils of chicks at D1 were suppressive. CD4(+)CD25(+) cells from D0 thymus, when injected back into MHC-compatible chicks, migrated to cecal tonsils and lungs and were detected until 10 d post-injection. CD4(+)CD25(+) cells from cecal tonsils had a higher (P = 0.01) relative amount of CCR9 mRNA than CD4(+)CD25(+) cells from the thymus. It could be concluded that in chickens CD4(+)CD25(+) cells migrate from the thymus immediately post-hatch and preferentially colonize the gut associated lymphoid tissues. CD4(+)CD25(+) cells' preferential migration to cecal tonsils is likely directed through the CCR9 pathway in chickens.Revathi ShanmugasundaramRamesh K SelvarajPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 3, p e33970 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Revathi Shanmugasundaram Ramesh K Selvaraj CD4+CD25+ Regulatory T cell ontogeny and preferential migration to the cecal tonsils in chickens.
description	Thymic CD4(+)CD25(+) cells have regulatory-T-cell-like properties in chickens. This study examined the ontogeny of CD4(+)CD25(+) cells in the thymus and in peripheral compartments in chickens. CD4(+)CD25(+) cells started to appear in the thymus at day 15 of incubation (E15), although at low percentages. Expressed as a percentage of CD4(+) cells, CD4(+)CD25(+) cells increased (P<0.01) from 1.7% at E20 to 7.3% at 0 d post-hatch (D0). CD4(+)CD25(+) cells did not appear in the spleen or cecal tonsils of embryos. Expressed as a percentage of CD4(+) cells, CD4(+)CD25(+) cells increased (P<0.01) from 0% at D0 to 27% at D1 in cecal tonsils and from 0% at D0 to 11% at D1 in the spleen. Expressed as a percentage of all mononuclear cells, cecal tonsils at D1 had approximately 3.5-fold higher percentage of CD4(+)CD25(+) cells than the spleen at D1. CD4(+)CD25(+) cells from cecal tonsils of chicks at D1 were suppressive. CD4(+)CD25(+) cells from D0 thymus, when injected back into MHC-compatible chicks, migrated to cecal tonsils and lungs and were detected until 10 d post-injection. CD4(+)CD25(+) cells from cecal tonsils had a higher (P = 0.01) relative amount of CCR9 mRNA than CD4(+)CD25(+) cells from the thymus. It could be concluded that in chickens CD4(+)CD25(+) cells migrate from the thymus immediately post-hatch and preferentially colonize the gut associated lymphoid tissues. CD4(+)CD25(+) cells' preferential migration to cecal tonsils is likely directed through the CCR9 pathway in chickens.
format	article
author	Revathi Shanmugasundaram Ramesh K Selvaraj
author_facet	Revathi Shanmugasundaram Ramesh K Selvaraj
author_sort	Revathi Shanmugasundaram
title	CD4+CD25+ Regulatory T cell ontogeny and preferential migration to the cecal tonsils in chickens.
title_short	CD4+CD25+ Regulatory T cell ontogeny and preferential migration to the cecal tonsils in chickens.
title_full	CD4+CD25+ Regulatory T cell ontogeny and preferential migration to the cecal tonsils in chickens.
title_fullStr	CD4+CD25+ Regulatory T cell ontogeny and preferential migration to the cecal tonsils in chickens.
title_full_unstemmed	CD4+CD25+ Regulatory T cell ontogeny and preferential migration to the cecal tonsils in chickens.
title_sort	cd4+cd25+ regulatory t cell ontogeny and preferential migration to the cecal tonsils in chickens.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/1f9002c43ac94405a4810126db8e5644
work_keys_str_mv	AT revathishanmugasundaram cd4cd25regulatorytcellontogenyandpreferentialmigrationtothececaltonsilsinchickens AT rameshkselvaraj cd4cd25regulatorytcellontogenyandpreferentialmigrationtothececaltonsilsinchickens
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CD4+CD25+ Regulatory T cell ontogeny and preferential migration to the cecal tonsils in chickens.

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