Leptin Levels are Associated with Subclinical Cardiac Dysfunction in Obese Adolescents

Thamonwan Imerbtham,1 Piyanuch Thitiwuthikiat,1 Jirapas Jongjitwimol,2 Teonchit Nuamchit,1 Teerapat Yingchoncharoen,3 Duangduan Siriwittayawan1 1Department of Cardio-Thoracic Technology, Faculty of Allied Health Sciences, Naresuan University, Phitsanulok, Thailand; 2Department of Medical Technology,...

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Autores principales:	Imerbtham T, Thitiwuthikiat P, Jongjitwimol J, Nuamchit T, Yingchoncharoen T, Siriwittayawan D
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	leptin global longitudinal strain juvenile speckle tracking echocardiography uric acid Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/1f917b949c9847ad8d062ad8fbc7f2f4
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spelling	oai:doaj.org-article:1f917b949c9847ad8d062ad8fbc7f2f42021-12-02T11:32:14ZLeptin Levels are Associated with Subclinical Cardiac Dysfunction in Obese Adolescents1178-7007https://doaj.org/article/1f917b949c9847ad8d062ad8fbc7f2f42020-03-01T00:00:00Zhttps://www.dovepress.com/leptin-levels-are-associated-with-subclinical-cardiac-dysfunction-in-o-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Thamonwan Imerbtham,1 Piyanuch Thitiwuthikiat,1 Jirapas Jongjitwimol,2 Teonchit Nuamchit,1 Teerapat Yingchoncharoen,3 Duangduan Siriwittayawan1 1Department of Cardio-Thoracic Technology, Faculty of Allied Health Sciences, Naresuan University, Phitsanulok, Thailand; 2Department of Medical Technology, Faculty of Allied Health Sciences, Naresuan University, Phitsanulok, Thailand; 3Department of Internal Medicine, Faculty of Medicine, Mahidol University, Bangkok, ThailandCorrespondence: Duangduan SiriwittayawanDepartment of Cardio-Thoracic Technology, Faculty of Allied Health Sciences, Naresuan University, Phitsanulok 65000, ThailandTel +66 55 966 417Fax +66 55 966 234Email duangduans@nu.ac.thPurpose: The purposes of this study were to use speckle tracking echocardiography to confirm the influence of obesity on cardiac functions and to assess their relationships with leptin and uric acid levels in obese adolescents.Methods: Eighty-one participants aged 16– 19 years were recruited and classified as either non-obese (n = 30) or obese (n = 51). Global longitudinal strain (GLS), leptin and uric acid levels for each group were assessed and compared. The data from obese participants were then compared based on their leptin levels and analyzed for correlation using regression analysis.Results: The obese group had significantly lower absolute GLS compared to the non-obese group (19.10 ± 0.30 versus 21.10 ± 0.30%, p < 0.001). In obese group, subclinical cardiac dysfunction was worse in the hyperleptinemic group than that of the normoleptinemic group (p = 0.03). Multivariate regression analysis showed that leptin and triglyceride levels were negatively associated with absolute GLS. Leptin could predict the absolute GLS with β = − 0.35 (p = 0.02).Conclusion: Subclinical left ventricular systolic dysfunction was found in obese adolescents, while GLS was worse in the hyperleptinemic subjects. Leptin, but not uric acid, levels were associated with a worsening of GLS.Keywords: leptin, global longitudinal strain, juvenile, speckle tracking echocardiography, uric acidImerbtham TThitiwuthikiat PJongjitwimol JNuamchit TYingchoncharoen TSiriwittayawan DDove Medical Pressarticleleptinglobal longitudinal strainjuvenilespeckle tracking echocardiographyuric acidSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 13, Pp 925-933 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	leptin global longitudinal strain juvenile speckle tracking echocardiography uric acid Specialties of internal medicine RC581-951
spellingShingle	leptin global longitudinal strain juvenile speckle tracking echocardiography uric acid Specialties of internal medicine RC581-951 Imerbtham T Thitiwuthikiat P Jongjitwimol J Nuamchit T Yingchoncharoen T Siriwittayawan D Leptin Levels are Associated with Subclinical Cardiac Dysfunction in Obese Adolescents
description	Thamonwan Imerbtham,1 Piyanuch Thitiwuthikiat,1 Jirapas Jongjitwimol,2 Teonchit Nuamchit,1 Teerapat Yingchoncharoen,3 Duangduan Siriwittayawan1 1Department of Cardio-Thoracic Technology, Faculty of Allied Health Sciences, Naresuan University, Phitsanulok, Thailand; 2Department of Medical Technology, Faculty of Allied Health Sciences, Naresuan University, Phitsanulok, Thailand; 3Department of Internal Medicine, Faculty of Medicine, Mahidol University, Bangkok, ThailandCorrespondence: Duangduan SiriwittayawanDepartment of Cardio-Thoracic Technology, Faculty of Allied Health Sciences, Naresuan University, Phitsanulok 65000, ThailandTel +66 55 966 417Fax +66 55 966 234Email duangduans@nu.ac.thPurpose: The purposes of this study were to use speckle tracking echocardiography to confirm the influence of obesity on cardiac functions and to assess their relationships with leptin and uric acid levels in obese adolescents.Methods: Eighty-one participants aged 16– 19 years were recruited and classified as either non-obese (n = 30) or obese (n = 51). Global longitudinal strain (GLS), leptin and uric acid levels for each group were assessed and compared. The data from obese participants were then compared based on their leptin levels and analyzed for correlation using regression analysis.Results: The obese group had significantly lower absolute GLS compared to the non-obese group (19.10 ± 0.30 versus 21.10 ± 0.30%, p < 0.001). In obese group, subclinical cardiac dysfunction was worse in the hyperleptinemic group than that of the normoleptinemic group (p = 0.03). Multivariate regression analysis showed that leptin and triglyceride levels were negatively associated with absolute GLS. Leptin could predict the absolute GLS with β = − 0.35 (p = 0.02).Conclusion: Subclinical left ventricular systolic dysfunction was found in obese adolescents, while GLS was worse in the hyperleptinemic subjects. Leptin, but not uric acid, levels were associated with a worsening of GLS.Keywords: leptin, global longitudinal strain, juvenile, speckle tracking echocardiography, uric acid
format	article
author	Imerbtham T Thitiwuthikiat P Jongjitwimol J Nuamchit T Yingchoncharoen T Siriwittayawan D
author_facet	Imerbtham T Thitiwuthikiat P Jongjitwimol J Nuamchit T Yingchoncharoen T Siriwittayawan D
author_sort	Imerbtham T
title	Leptin Levels are Associated with Subclinical Cardiac Dysfunction in Obese Adolescents
title_short	Leptin Levels are Associated with Subclinical Cardiac Dysfunction in Obese Adolescents
title_full	Leptin Levels are Associated with Subclinical Cardiac Dysfunction in Obese Adolescents
title_fullStr	Leptin Levels are Associated with Subclinical Cardiac Dysfunction in Obese Adolescents
title_full_unstemmed	Leptin Levels are Associated with Subclinical Cardiac Dysfunction in Obese Adolescents
title_sort	leptin levels are associated with subclinical cardiac dysfunction in obese adolescents
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/1f917b949c9847ad8d062ad8fbc7f2f4
work_keys_str_mv	AT imerbthamt leptinlevelsareassociatedwithsubclinicalcardiacdysfunctioninobeseadolescents AT thitiwuthikiatp leptinlevelsareassociatedwithsubclinicalcardiacdysfunctioninobeseadolescents AT jongjitwimolj leptinlevelsareassociatedwithsubclinicalcardiacdysfunctioninobeseadolescents AT nuamchitt leptinlevelsareassociatedwithsubclinicalcardiacdysfunctioninobeseadolescents AT yingchoncharoent leptinlevelsareassociatedwithsubclinicalcardiacdysfunctioninobeseadolescents AT siriwittayawand leptinlevelsareassociatedwithsubclinicalcardiacdysfunctioninobeseadolescents
_version_	1718395807679381504

Leptin Levels are Associated with Subclinical Cardiac Dysfunction in Obese Adolescents

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