Subventricular zone involvement in Glioblastoma – A proteomic evaluation and clinicoradiological correlation

Abstract Glioblastoma multiforme (GBM), the most malignant of all gliomas is characterized by a high degree of heterogeneity and poor response to treatment. The sub-ventricular zone (SVZ) is the major site of neurogenesis in the brain and is rich in neural stem cells. Based on the proximity of the G...

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Autores principales:	Kishore Gollapalli, Saicharan Ghantasala, Sachendra Kumar, Rajneesh Srivastava, Srikanth Rapole, Aliasgar Moiyadi, Sridhar Epari, Sanjeeva Srivastava
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1f942a06eb264b41ac64606822821b77
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spelling	oai:doaj.org-article:1f942a06eb264b41ac64606822821b772021-12-02T16:06:12ZSubventricular zone involvement in Glioblastoma – A proteomic evaluation and clinicoradiological correlation10.1038/s41598-017-01202-82045-2322https://doaj.org/article/1f942a06eb264b41ac64606822821b772017-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-01202-8https://doaj.org/toc/2045-2322Abstract Glioblastoma multiforme (GBM), the most malignant of all gliomas is characterized by a high degree of heterogeneity and poor response to treatment. The sub-ventricular zone (SVZ) is the major site of neurogenesis in the brain and is rich in neural stem cells. Based on the proximity of the GBM tumors to the SVZ, the tumors can be further classified into SVZ+ and SVZ−. The tumors located in close contact with the SVZ are classified as SVZ+, while the tumors located distantly from the SVZ are classified as SVZ−. To gain an insight into the increased aggressiveness of SVZ+ over SVZ− tumors, we have used proteomics techniques like 2D-DIGE and LC-MS/MS to investigate any possible proteomic differences between the two subtypes. Serum proteomic analysis revealed significant alterations of various acute phase proteins and lipid carrying proteins, while tissue proteomic analysis revealed significant alterations in cytoskeletal, lipid binding, chaperone and cell cycle regulating proteins, which are already known to be associated with disease pathobiology. These findings provide cues to molecular basis behind increased aggressiveness of SVZ+ GBM tumors over SVZ− GBM tumors and plausible therapeutic targets to improve treatment modalities for these highly invasive tumors.Kishore GollapalliSaicharan GhantasalaSachendra KumarRajneesh SrivastavaSrikanth RapoleAliasgar MoiyadiSridhar EpariSanjeeva SrivastavaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kishore Gollapalli Saicharan Ghantasala Sachendra Kumar Rajneesh Srivastava Srikanth Rapole Aliasgar Moiyadi Sridhar Epari Sanjeeva Srivastava Subventricular zone involvement in Glioblastoma – A proteomic evaluation and clinicoradiological correlation
description	Abstract Glioblastoma multiforme (GBM), the most malignant of all gliomas is characterized by a high degree of heterogeneity and poor response to treatment. The sub-ventricular zone (SVZ) is the major site of neurogenesis in the brain and is rich in neural stem cells. Based on the proximity of the GBM tumors to the SVZ, the tumors can be further classified into SVZ+ and SVZ−. The tumors located in close contact with the SVZ are classified as SVZ+, while the tumors located distantly from the SVZ are classified as SVZ−. To gain an insight into the increased aggressiveness of SVZ+ over SVZ− tumors, we have used proteomics techniques like 2D-DIGE and LC-MS/MS to investigate any possible proteomic differences between the two subtypes. Serum proteomic analysis revealed significant alterations of various acute phase proteins and lipid carrying proteins, while tissue proteomic analysis revealed significant alterations in cytoskeletal, lipid binding, chaperone and cell cycle regulating proteins, which are already known to be associated with disease pathobiology. These findings provide cues to molecular basis behind increased aggressiveness of SVZ+ GBM tumors over SVZ− GBM tumors and plausible therapeutic targets to improve treatment modalities for these highly invasive tumors.
format	article
author	Kishore Gollapalli Saicharan Ghantasala Sachendra Kumar Rajneesh Srivastava Srikanth Rapole Aliasgar Moiyadi Sridhar Epari Sanjeeva Srivastava
author_facet	Kishore Gollapalli Saicharan Ghantasala Sachendra Kumar Rajneesh Srivastava Srikanth Rapole Aliasgar Moiyadi Sridhar Epari Sanjeeva Srivastava
author_sort	Kishore Gollapalli
title	Subventricular zone involvement in Glioblastoma – A proteomic evaluation and clinicoradiological correlation
title_short	Subventricular zone involvement in Glioblastoma – A proteomic evaluation and clinicoradiological correlation
title_full	Subventricular zone involvement in Glioblastoma – A proteomic evaluation and clinicoradiological correlation
title_fullStr	Subventricular zone involvement in Glioblastoma – A proteomic evaluation and clinicoradiological correlation
title_full_unstemmed	Subventricular zone involvement in Glioblastoma – A proteomic evaluation and clinicoradiological correlation
title_sort	subventricular zone involvement in glioblastoma – a proteomic evaluation and clinicoradiological correlation
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/1f942a06eb264b41ac64606822821b77
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Subventricular zone involvement in Glioblastoma – A proteomic evaluation and clinicoradiological correlation

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