The Isoform GC1f of the Vitamin D Binding Protein Is Associated with Bronchiectasis Severity

Vitamin D modulates immune responses and its deficiency has been observed in more than 60% of bronchiectasis patients. Vitamin D binding protein (DBP) is coded by the GC gene, is involved in the transport of vitamin D, and includes a number of isoforms based on single nucleotide polymorphisms (SNPs)...

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Autores principales:	Martina Oriano, Stefano Aliberti, Franca Rosa Guerini, Cristina Agliardi, Carlotta Di Francesco, Alice Gelmini, Leonardo Terranova, Milena Zanzottera, Paola Marchisio, Mario Clerici, Francesco Blasi
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	bronchiectasis vitamin D DBP rehabilitation Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/1f94f7c03fae4fd1b68fbb15702895d0
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spelling	oai:doaj.org-article:1f94f7c03fae4fd1b68fbb15702895d02021-11-25T16:49:09ZThe Isoform GC1f of the Vitamin D Binding Protein Is Associated with Bronchiectasis Severity10.3390/biomedicines91115732227-9059https://doaj.org/article/1f94f7c03fae4fd1b68fbb15702895d02021-10-01T00:00:00Zhttps://www.mdpi.com/2227-9059/9/11/1573https://doaj.org/toc/2227-9059Vitamin D modulates immune responses and its deficiency has been observed in more than 60% of bronchiectasis patients. Vitamin D binding protein (DBP) is coded by the GC gene, is involved in the transport of vitamin D, and includes a number of isoforms based on single nucleotide polymorphisms (SNPs) in the coding region at rs7041 and rs4855. We evaluated the possible clinical impact of DBP polymorphisms and isoforms in an observational, cross-sectional study conducted in 116 bronchiectasis patients, who were genetically characterized for rs4588 and rs7041 SNPs. Results showed that the GC1f isoform (rs7041/rs4588 A/G) correlated with a more severe disease (18.9% vs. 6.3%, <i>p</i> = 0.038), a higher incidence of chronic infections (63.6% vs. 42%, <i>p</i> = 0.041), and a lower BACI score (0.0 (0.0, 2.5) vs. 3.0 (0.0, 3.0), <i>p</i> = 0.035). Moreover, blood concentration of vitamin D was higher in patients carrying GC1s (median (IQR): 20.5 (14.3, 29.7 vs. 15.8 (7.6, 22.4), <i>p</i> = 0.037)). Patients carrying GC1f isoform have a more severe disease, more chronic infections and lower asthmatic comorbidity in comparison to those without the GC1f isoform. Presence of the GC1s isoform (rs7041/rs4588 C/G) seems to be associated to a milder clinical phenotype with increased vitamin D levels and lower comorbidities score.Martina OrianoStefano AlibertiFranca Rosa GueriniCristina AgliardiCarlotta Di FrancescoAlice GelminiLeonardo TerranovaMilena ZanzotteraPaola MarchisioMario ClericiFrancesco BlasiMDPI AGarticlebronchiectasisvitamin DDBPrehabilitationBiology (General)QH301-705.5ENBiomedicines, Vol 9, Iss 1573, p 1573 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	bronchiectasis vitamin D DBP rehabilitation Biology (General) QH301-705.5
spellingShingle	bronchiectasis vitamin D DBP rehabilitation Biology (General) QH301-705.5 Martina Oriano Stefano Aliberti Franca Rosa Guerini Cristina Agliardi Carlotta Di Francesco Alice Gelmini Leonardo Terranova Milena Zanzottera Paola Marchisio Mario Clerici Francesco Blasi The Isoform GC1f of the Vitamin D Binding Protein Is Associated with Bronchiectasis Severity
description	Vitamin D modulates immune responses and its deficiency has been observed in more than 60% of bronchiectasis patients. Vitamin D binding protein (DBP) is coded by the GC gene, is involved in the transport of vitamin D, and includes a number of isoforms based on single nucleotide polymorphisms (SNPs) in the coding region at rs7041 and rs4855. We evaluated the possible clinical impact of DBP polymorphisms and isoforms in an observational, cross-sectional study conducted in 116 bronchiectasis patients, who were genetically characterized for rs4588 and rs7041 SNPs. Results showed that the GC1f isoform (rs7041/rs4588 A/G) correlated with a more severe disease (18.9% vs. 6.3%, <i>p</i> = 0.038), a higher incidence of chronic infections (63.6% vs. 42%, <i>p</i> = 0.041), and a lower BACI score (0.0 (0.0, 2.5) vs. 3.0 (0.0, 3.0), <i>p</i> = 0.035). Moreover, blood concentration of vitamin D was higher in patients carrying GC1s (median (IQR): 20.5 (14.3, 29.7 vs. 15.8 (7.6, 22.4), <i>p</i> = 0.037)). Patients carrying GC1f isoform have a more severe disease, more chronic infections and lower asthmatic comorbidity in comparison to those without the GC1f isoform. Presence of the GC1s isoform (rs7041/rs4588 C/G) seems to be associated to a milder clinical phenotype with increased vitamin D levels and lower comorbidities score.
format	article
author	Martina Oriano Stefano Aliberti Franca Rosa Guerini Cristina Agliardi Carlotta Di Francesco Alice Gelmini Leonardo Terranova Milena Zanzottera Paola Marchisio Mario Clerici Francesco Blasi
author_facet	Martina Oriano Stefano Aliberti Franca Rosa Guerini Cristina Agliardi Carlotta Di Francesco Alice Gelmini Leonardo Terranova Milena Zanzottera Paola Marchisio Mario Clerici Francesco Blasi
author_sort	Martina Oriano
title	The Isoform GC1f of the Vitamin D Binding Protein Is Associated with Bronchiectasis Severity
title_short	The Isoform GC1f of the Vitamin D Binding Protein Is Associated with Bronchiectasis Severity
title_full	The Isoform GC1f of the Vitamin D Binding Protein Is Associated with Bronchiectasis Severity
title_fullStr	The Isoform GC1f of the Vitamin D Binding Protein Is Associated with Bronchiectasis Severity
title_full_unstemmed	The Isoform GC1f of the Vitamin D Binding Protein Is Associated with Bronchiectasis Severity
title_sort	isoform gc1f of the vitamin d binding protein is associated with bronchiectasis severity
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/1f94f7c03fae4fd1b68fbb15702895d0
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The Isoform GC1f of the Vitamin D Binding Protein Is Associated with Bronchiectasis Severity

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