Rhodaelectro-catalyzed access to chromones via formyl C–H activation towards peptide electro-labeling

The chromone scaffold is present in drugs and bioactive natural products, but conventional approaches to access chromones require stoichiometric amounts of oxidants. Here, the authors report rhodaelectro-catalyzed assembly of chromones by electrochemical formyl C–H activations, providing the basis f...

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Autores principales:	Maximilian Stangier, Antonis M. Messinis, João C. A. Oliveira, Hao Yu, Lutz Ackermann
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1f96bb1f461540d38bee6aeed5f4505e
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spelling	oai:doaj.org-article:1f96bb1f461540d38bee6aeed5f4505e2021-12-02T16:34:06ZRhodaelectro-catalyzed access to chromones via formyl C–H activation towards peptide electro-labeling10.1038/s41467-021-25005-82041-1723https://doaj.org/article/1f96bb1f461540d38bee6aeed5f4505e2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25005-8https://doaj.org/toc/2041-1723The chromone scaffold is present in drugs and bioactive natural products, but conventional approaches to access chromones require stoichiometric amounts of oxidants. Here, the authors report rhodaelectro-catalyzed assembly of chromones by electrochemical formyl C–H activations, providing the basis for late-stage peptide diversification.Maximilian StangierAntonis M. MessinisJoão C. A. OliveiraHao YuLutz AckermannNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Maximilian Stangier Antonis M. Messinis João C. A. Oliveira Hao Yu Lutz Ackermann Rhodaelectro-catalyzed access to chromones via formyl C–H activation towards peptide electro-labeling
description	The chromone scaffold is present in drugs and bioactive natural products, but conventional approaches to access chromones require stoichiometric amounts of oxidants. Here, the authors report rhodaelectro-catalyzed assembly of chromones by electrochemical formyl C–H activations, providing the basis for late-stage peptide diversification.
format	article
author	Maximilian Stangier Antonis M. Messinis João C. A. Oliveira Hao Yu Lutz Ackermann
author_facet	Maximilian Stangier Antonis M. Messinis João C. A. Oliveira Hao Yu Lutz Ackermann
author_sort	Maximilian Stangier
title	Rhodaelectro-catalyzed access to chromones via formyl C–H activation towards peptide electro-labeling
title_short	Rhodaelectro-catalyzed access to chromones via formyl C–H activation towards peptide electro-labeling
title_full	Rhodaelectro-catalyzed access to chromones via formyl C–H activation towards peptide electro-labeling
title_fullStr	Rhodaelectro-catalyzed access to chromones via formyl C–H activation towards peptide electro-labeling
title_full_unstemmed	Rhodaelectro-catalyzed access to chromones via formyl C–H activation towards peptide electro-labeling
title_sort	rhodaelectro-catalyzed access to chromones via formyl c–h activation towards peptide electro-labeling
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/1f96bb1f461540d38bee6aeed5f4505e
work_keys_str_mv	AT maximilianstangier rhodaelectrocatalyzedaccesstochromonesviaformylchactivationtowardspeptideelectrolabeling AT antonismmessinis rhodaelectrocatalyzedaccesstochromonesviaformylchactivationtowardspeptideelectrolabeling AT joaocaoliveira rhodaelectrocatalyzedaccesstochromonesviaformylchactivationtowardspeptideelectrolabeling AT haoyu rhodaelectrocatalyzedaccesstochromonesviaformylchactivationtowardspeptideelectrolabeling AT lutzackermann rhodaelectrocatalyzedaccesstochromonesviaformylchactivationtowardspeptideelectrolabeling
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Rhodaelectro-catalyzed access to chromones via formyl C–H activation towards peptide electro-labeling

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