Transmission dynamics and prospects for the elimination of canine rabies.

Rabies has been eliminated from domestic dog populations in Western Europe and North America, but continues to kill many thousands of people throughout Africa and Asia every year. A quantitative understanding of transmission dynamics in domestic dog populations provides critical information to asses...

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Autores principales:	Katie Hampson, Jonathan Dushoff, Sarah Cleaveland, Daniel T Haydon, Magai Kaare, Craig Packer, Andy Dobson
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2009
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/1f97644208e24f7cb95b5d46026a350e
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spelling	oai:doaj.org-article:1f97644208e24f7cb95b5d46026a350e2021-11-25T05:33:46ZTransmission dynamics and prospects for the elimination of canine rabies.1544-91731545-788510.1371/journal.pbio.1000053https://doaj.org/article/1f97644208e24f7cb95b5d46026a350e2009-03-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19278295/pdf/?tool=EBIhttps://doaj.org/toc/1544-9173https://doaj.org/toc/1545-7885Rabies has been eliminated from domestic dog populations in Western Europe and North America, but continues to kill many thousands of people throughout Africa and Asia every year. A quantitative understanding of transmission dynamics in domestic dog populations provides critical information to assess whether global elimination of canine rabies is possible. We report extensive observations of individual rabid animals in Tanzania and generate a uniquely detailed analysis of transmission biology, which explains important epidemiological features, including the level of variation in epidemic trajectories. We found that the basic reproductive number for rabies, R0, is very low in our study area in rural Africa (approximately 1.2) and throughout its historic global range (<2). This finding provides strong support for the feasibility of controlling endemic canine rabies by vaccination, even near wildlife areas with large wild carnivore populations. However, we show that rapid turnover of domestic dog populations has been a major obstacle to successful control in developing countries, thus regular pulse vaccinations will be required to maintain population-level immunity between campaigns. Nonetheless our analyses suggest that with sustained, international commitment, global elimination of rabies from domestic dog populations, the most dangerous vector to humans, is a realistic goal.Katie HampsonJonathan DushoffSarah CleavelandDaniel T HaydonMagai KaareCraig PackerAndy DobsonPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Biology, Vol 7, Iss 3, p e53 (2009)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Katie Hampson Jonathan Dushoff Sarah Cleaveland Daniel T Haydon Magai Kaare Craig Packer Andy Dobson Transmission dynamics and prospects for the elimination of canine rabies.
description	Rabies has been eliminated from domestic dog populations in Western Europe and North America, but continues to kill many thousands of people throughout Africa and Asia every year. A quantitative understanding of transmission dynamics in domestic dog populations provides critical information to assess whether global elimination of canine rabies is possible. We report extensive observations of individual rabid animals in Tanzania and generate a uniquely detailed analysis of transmission biology, which explains important epidemiological features, including the level of variation in epidemic trajectories. We found that the basic reproductive number for rabies, R0, is very low in our study area in rural Africa (approximately 1.2) and throughout its historic global range (<2). This finding provides strong support for the feasibility of controlling endemic canine rabies by vaccination, even near wildlife areas with large wild carnivore populations. However, we show that rapid turnover of domestic dog populations has been a major obstacle to successful control in developing countries, thus regular pulse vaccinations will be required to maintain population-level immunity between campaigns. Nonetheless our analyses suggest that with sustained, international commitment, global elimination of rabies from domestic dog populations, the most dangerous vector to humans, is a realistic goal.
format	article
author	Katie Hampson Jonathan Dushoff Sarah Cleaveland Daniel T Haydon Magai Kaare Craig Packer Andy Dobson
author_facet	Katie Hampson Jonathan Dushoff Sarah Cleaveland Daniel T Haydon Magai Kaare Craig Packer Andy Dobson
author_sort	Katie Hampson
title	Transmission dynamics and prospects for the elimination of canine rabies.
title_short	Transmission dynamics and prospects for the elimination of canine rabies.
title_full	Transmission dynamics and prospects for the elimination of canine rabies.
title_fullStr	Transmission dynamics and prospects for the elimination of canine rabies.
title_full_unstemmed	Transmission dynamics and prospects for the elimination of canine rabies.
title_sort	transmission dynamics and prospects for the elimination of canine rabies.
publisher	Public Library of Science (PLoS)
publishDate	2009
url	https://doaj.org/article/1f97644208e24f7cb95b5d46026a350e
work_keys_str_mv	AT katiehampson transmissiondynamicsandprospectsfortheeliminationofcaninerabies AT jonathandushoff transmissiondynamicsandprospectsfortheeliminationofcaninerabies AT sarahcleaveland transmissiondynamicsandprospectsfortheeliminationofcaninerabies AT danielthaydon transmissiondynamicsandprospectsfortheeliminationofcaninerabies AT magaikaare transmissiondynamicsandprospectsfortheeliminationofcaninerabies AT craigpacker transmissiondynamicsandprospectsfortheeliminationofcaninerabies AT andydobson transmissiondynamicsandprospectsfortheeliminationofcaninerabies
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Transmission dynamics and prospects for the elimination of canine rabies.

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