Discovery of cationic nonribosomal peptides as Gram-negative antibiotics through global genome mining

Microbial genomes encode enzymes for biosynthesis of many uncharacterized peptides. Here, the authors screen over 7,300 bacterial genomes for potential biosynthesis of cationic non-ribosomal peptides, and identify two novel peptides with activities against antibiotic-resistant Gram-negative pathogen...

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Autores principales:	Yong-Xin Li, Zheng Zhong, Wei-Peng Zhang, Pei-Yuan Qian
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1f977197bcd24fb09fdce82c6abb4807
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spelling	oai:doaj.org-article:1f977197bcd24fb09fdce82c6abb48072021-12-02T15:33:34ZDiscovery of cationic nonribosomal peptides as Gram-negative antibiotics through global genome mining10.1038/s41467-018-05781-62041-1723https://doaj.org/article/1f977197bcd24fb09fdce82c6abb48072018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05781-6https://doaj.org/toc/2041-1723Microbial genomes encode enzymes for biosynthesis of many uncharacterized peptides. Here, the authors screen over 7,300 bacterial genomes for potential biosynthesis of cationic non-ribosomal peptides, and identify two novel peptides with activities against antibiotic-resistant Gram-negative pathogens.Yong-Xin LiZheng ZhongWei-Peng ZhangPei-Yuan QianNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yong-Xin Li Zheng Zhong Wei-Peng Zhang Pei-Yuan Qian Discovery of cationic nonribosomal peptides as Gram-negative antibiotics through global genome mining
description	Microbial genomes encode enzymes for biosynthesis of many uncharacterized peptides. Here, the authors screen over 7,300 bacterial genomes for potential biosynthesis of cationic non-ribosomal peptides, and identify two novel peptides with activities against antibiotic-resistant Gram-negative pathogens.
format	article
author	Yong-Xin Li Zheng Zhong Wei-Peng Zhang Pei-Yuan Qian
author_facet	Yong-Xin Li Zheng Zhong Wei-Peng Zhang Pei-Yuan Qian
author_sort	Yong-Xin Li
title	Discovery of cationic nonribosomal peptides as Gram-negative antibiotics through global genome mining
title_short	Discovery of cationic nonribosomal peptides as Gram-negative antibiotics through global genome mining
title_full	Discovery of cationic nonribosomal peptides as Gram-negative antibiotics through global genome mining
title_fullStr	Discovery of cationic nonribosomal peptides as Gram-negative antibiotics through global genome mining
title_full_unstemmed	Discovery of cationic nonribosomal peptides as Gram-negative antibiotics through global genome mining
title_sort	discovery of cationic nonribosomal peptides as gram-negative antibiotics through global genome mining
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/1f977197bcd24fb09fdce82c6abb4807
work_keys_str_mv	AT yongxinli discoveryofcationicnonribosomalpeptidesasgramnegativeantibioticsthroughglobalgenomemining AT zhengzhong discoveryofcationicnonribosomalpeptidesasgramnegativeantibioticsthroughglobalgenomemining AT weipengzhang discoveryofcationicnonribosomalpeptidesasgramnegativeantibioticsthroughglobalgenomemining AT peiyuanqian discoveryofcationicnonribosomalpeptidesasgramnegativeantibioticsthroughglobalgenomemining
_version_	1718387069341925376

Discovery of cationic nonribosomal peptides as Gram-negative antibiotics through global genome mining

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