Choline Intake Correlates with Cognitive Performance among Elder Adults in the United States

Objective. This research attempted to explore the neuroprotective effect of choline and establish evidence for future dietary recommendations and nutritional interventions to maintain a proper cognitive function among elders aged >60 years in the US. Method. This cross-sectional study retrieved d...

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Autores principales:	Lu Liu, Song Qiao, Liying Zhuang, Shanhu Xu, Linhui Chen, Qilun Lai, Wenfeng Wang
Formato:	article
Lenguaje:	EN
Publicado:	Hindawi Limited 2021
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/1f9b8505fe234443b50568addc9c53f4
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spelling	oai:doaj.org-article:1f9b8505fe234443b50568addc9c53f42021-11-08T02:35:32ZCholine Intake Correlates with Cognitive Performance among Elder Adults in the United States1875-858410.1155/2021/2962245https://doaj.org/article/1f9b8505fe234443b50568addc9c53f42021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/2962245https://doaj.org/toc/1875-8584Objective. This research attempted to explore the neuroprotective effect of choline and establish evidence for future dietary recommendations and nutritional interventions to maintain a proper cognitive function among elders aged >60 years in the US. Method. This cross-sectional study retrieved data of 2,393 eligible elderly participants from the 2011-2014 National Health and Nutrition Examination Survey. Combining dietary and supplement choline intake, total choline intake was evaluated using the 24-hour dietary recall method and the dietary supplement questionnaire. Total choline intake was categorized into tertiles, which ranged at <187.60 mg/day (T1), 187.60-399.50 mg/day (T2), and >399.50 mg/day (T3). The Consortium to Establish a Registry for Alzheimer’s Disease (CERAD) Word Learning subtest, Animal Fluency (AF) test, and Digit Symbol Substitution test (DSST) was used to measure cognitive function. Participants who scored the lowest 25th percentile in each cognitive test were classified in the low cognitive function (LC) group. Logistic regression models were implemented to examine the association between total choline intake and the incidence of LC. Results. In the CERAD test, the risk of LC was significantly lower in T2 than T1 (OR: 0.668, 95% CI: 0.493-0.904, and P=0.006) when adjusted for age, gender, BMI, alcohol consumption, and hypertension. Similarly, T2 was associated with a significantly lower risk of LC when assessed by the AF test (OR: 0.606, 95% CI: 0.580-0.724, and P<0.001) and DSST (0.584, 95% CI: 0.515-0.661, and P<0.001). In all three cognitive measures, the T3 of the total choline intake was not associated with cognitive function compared to T1. Conclusion. Total choline intake at 187.06-399.50 mg/day reduces the risk of LC by approximately 50% compared to intake at <187.6 mg/day. The findings of this research may be used to establish dietary recommendations and nutritional interventions to optimize the cognitive function among elders.Lu LiuSong QiaoLiying ZhuangShanhu XuLinhui ChenQilun LaiWenfeng WangHindawi LimitedarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENBehavioural Neurology, Vol 2021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Lu Liu Song Qiao Liying Zhuang Shanhu Xu Linhui Chen Qilun Lai Wenfeng Wang Choline Intake Correlates with Cognitive Performance among Elder Adults in the United States
description	Objective. This research attempted to explore the neuroprotective effect of choline and establish evidence for future dietary recommendations and nutritional interventions to maintain a proper cognitive function among elders aged >60 years in the US. Method. This cross-sectional study retrieved data of 2,393 eligible elderly participants from the 2011-2014 National Health and Nutrition Examination Survey. Combining dietary and supplement choline intake, total choline intake was evaluated using the 24-hour dietary recall method and the dietary supplement questionnaire. Total choline intake was categorized into tertiles, which ranged at <187.60 mg/day (T1), 187.60-399.50 mg/day (T2), and >399.50 mg/day (T3). The Consortium to Establish a Registry for Alzheimer’s Disease (CERAD) Word Learning subtest, Animal Fluency (AF) test, and Digit Symbol Substitution test (DSST) was used to measure cognitive function. Participants who scored the lowest 25th percentile in each cognitive test were classified in the low cognitive function (LC) group. Logistic regression models were implemented to examine the association between total choline intake and the incidence of LC. Results. In the CERAD test, the risk of LC was significantly lower in T2 than T1 (OR: 0.668, 95% CI: 0.493-0.904, and P=0.006) when adjusted for age, gender, BMI, alcohol consumption, and hypertension. Similarly, T2 was associated with a significantly lower risk of LC when assessed by the AF test (OR: 0.606, 95% CI: 0.580-0.724, and P<0.001) and DSST (0.584, 95% CI: 0.515-0.661, and P<0.001). In all three cognitive measures, the T3 of the total choline intake was not associated with cognitive function compared to T1. Conclusion. Total choline intake at 187.06-399.50 mg/day reduces the risk of LC by approximately 50% compared to intake at <187.6 mg/day. The findings of this research may be used to establish dietary recommendations and nutritional interventions to optimize the cognitive function among elders.
format	article
author	Lu Liu Song Qiao Liying Zhuang Shanhu Xu Linhui Chen Qilun Lai Wenfeng Wang
author_facet	Lu Liu Song Qiao Liying Zhuang Shanhu Xu Linhui Chen Qilun Lai Wenfeng Wang
author_sort	Lu Liu
title	Choline Intake Correlates with Cognitive Performance among Elder Adults in the United States
title_short	Choline Intake Correlates with Cognitive Performance among Elder Adults in the United States
title_full	Choline Intake Correlates with Cognitive Performance among Elder Adults in the United States
title_fullStr	Choline Intake Correlates with Cognitive Performance among Elder Adults in the United States
title_full_unstemmed	Choline Intake Correlates with Cognitive Performance among Elder Adults in the United States
title_sort	choline intake correlates with cognitive performance among elder adults in the united states
publisher	Hindawi Limited
publishDate	2021
url	https://doaj.org/article/1f9b8505fe234443b50568addc9c53f4
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Choline Intake Correlates with Cognitive Performance among Elder Adults in the United States

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