Human Milk Growth Factors and Their Role in NEC Prevention: A Narrative Review

Growing evidence demonstrates human milk’s protective effect against necrotizing enterocolitis (NEC). Human milk derives these properties from biologically active compounds that influence intestinal growth, barrier function, microvascular development, and immunological maturation. Among these protec...

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Autores principales:	Daniel J. York, Anne L. Smazal, Daniel T. Robinson, Isabelle G. De Plaen
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	necrotizing enterocolitis human milk growth factors Epidermal Growth Factor (EGF) Heparin-Binding EGF-like Growth Factor (HB-EGF) Insulin-like Growth Factor 1 (IGF-1) Insulin-like Growth Factor 2 (IGF-2) Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/1f9c9a356c7c41799d266b4887a048cb
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spelling	oai:doaj.org-article:1f9c9a356c7c41799d266b4887a048cb2021-11-25T18:33:45ZHuman Milk Growth Factors and Their Role in NEC Prevention: A Narrative Review10.3390/nu131137512072-6643https://doaj.org/article/1f9c9a356c7c41799d266b4887a048cb2021-10-01T00:00:00Zhttps://www.mdpi.com/2072-6643/13/11/3751https://doaj.org/toc/2072-6643Growing evidence demonstrates human milk’s protective effect against necrotizing enterocolitis (NEC). Human milk derives these properties from biologically active compounds that influence intestinal growth, barrier function, microvascular development, and immunological maturation. Among these protective compounds are growth factors that are secreted into milk with relatively high concentrations during the early postnatal period, when newborns are most susceptible to NEC. This paper reviews the current knowledge on human milk growth factors and their mechanisms of action relevant to NEC prevention. It will also discuss the stability of these growth factors with human milk pasteurization and their potential for use as supplements to infant formulas with the goal of preventing NEC.Daniel J. YorkAnne L. SmazalDaniel T. RobinsonIsabelle G. De PlaenMDPI AGarticlenecrotizing enterocolitishuman milkgrowth factorsEpidermal Growth Factor (EGF)Heparin-Binding EGF-like Growth Factor (HB-EGF)Insulin-like Growth Factor 1 (IGF-1) Insulin-like Growth Factor 2 (IGF-2)Nutrition. Foods and food supplyTX341-641ENNutrients, Vol 13, Iss 3751, p 3751 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	necrotizing enterocolitis human milk growth factors Epidermal Growth Factor (EGF) Heparin-Binding EGF-like Growth Factor (HB-EGF) Insulin-like Growth Factor 1 (IGF-1) Insulin-like Growth Factor 2 (IGF-2) Nutrition. Foods and food supply TX341-641
spellingShingle	necrotizing enterocolitis human milk growth factors Epidermal Growth Factor (EGF) Heparin-Binding EGF-like Growth Factor (HB-EGF) Insulin-like Growth Factor 1 (IGF-1) Insulin-like Growth Factor 2 (IGF-2) Nutrition. Foods and food supply TX341-641 Daniel J. York Anne L. Smazal Daniel T. Robinson Isabelle G. De Plaen Human Milk Growth Factors and Their Role in NEC Prevention: A Narrative Review
description	Growing evidence demonstrates human milk’s protective effect against necrotizing enterocolitis (NEC). Human milk derives these properties from biologically active compounds that influence intestinal growth, barrier function, microvascular development, and immunological maturation. Among these protective compounds are growth factors that are secreted into milk with relatively high concentrations during the early postnatal period, when newborns are most susceptible to NEC. This paper reviews the current knowledge on human milk growth factors and their mechanisms of action relevant to NEC prevention. It will also discuss the stability of these growth factors with human milk pasteurization and their potential for use as supplements to infant formulas with the goal of preventing NEC.
format	article
author	Daniel J. York Anne L. Smazal Daniel T. Robinson Isabelle G. De Plaen
author_facet	Daniel J. York Anne L. Smazal Daniel T. Robinson Isabelle G. De Plaen
author_sort	Daniel J. York
title	Human Milk Growth Factors and Their Role in NEC Prevention: A Narrative Review
title_short	Human Milk Growth Factors and Their Role in NEC Prevention: A Narrative Review
title_full	Human Milk Growth Factors and Their Role in NEC Prevention: A Narrative Review
title_fullStr	Human Milk Growth Factors and Their Role in NEC Prevention: A Narrative Review
title_full_unstemmed	Human Milk Growth Factors and Their Role in NEC Prevention: A Narrative Review
title_sort	human milk growth factors and their role in nec prevention: a narrative review
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/1f9c9a356c7c41799d266b4887a048cb
work_keys_str_mv	AT danieljyork humanmilkgrowthfactorsandtheirroleinnecpreventionanarrativereview AT annelsmazal humanmilkgrowthfactorsandtheirroleinnecpreventionanarrativereview AT danieltrobinson humanmilkgrowthfactorsandtheirroleinnecpreventionanarrativereview AT isabellegdeplaen humanmilkgrowthfactorsandtheirroleinnecpreventionanarrativereview
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Human Milk Growth Factors and Their Role in NEC Prevention: A Narrative Review

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