Cyclic peptide FXII inhibitor provides safe anticoagulation in a thrombosis model and in artificial lungs

Inhibiting thrombosis without inducing bleeding is a major challenge for anticoagulant agents. Here the authors describe a synthetic FXIIa inhibitor able to efficiently prevent thrombosis in mice and suppress coagulation in artificial lungs in rabbits without increasing the risk of bleeding.

Guardado en:

Detalles Bibliográficos
Autores principales:	Jonas Wilbs, Xu-Dong Kong, Simon J. Middendorp, Raja Prince, Alida Cooke, Caitlin T. Demarest, Mai M. Abdelhafez, Kalliope Roberts, Nao Umei, Patrick Gonschorek, Christina Lamers, Kaycie Deyle, Robert Rieben, Keith E. Cook, Anne Angelillo-Scherrer, Christian Heinis
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1f9ddb75be1e4a398c1ff63698dcaa1b
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:1f9ddb75be1e4a398c1ff63698dcaa1b
record_format	dspace
spelling	oai:doaj.org-article:1f9ddb75be1e4a398c1ff63698dcaa1b2021-12-02T18:49:31ZCyclic peptide FXII inhibitor provides safe anticoagulation in a thrombosis model and in artificial lungs10.1038/s41467-020-17648-w2041-1723https://doaj.org/article/1f9ddb75be1e4a398c1ff63698dcaa1b2020-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17648-whttps://doaj.org/toc/2041-1723Inhibiting thrombosis without inducing bleeding is a major challenge for anticoagulant agents. Here the authors describe a synthetic FXIIa inhibitor able to efficiently prevent thrombosis in mice and suppress coagulation in artificial lungs in rabbits without increasing the risk of bleeding.Jonas WilbsXu-Dong KongSimon J. MiddendorpRaja PrinceAlida CookeCaitlin T. DemarestMai M. AbdelhafezKalliope RobertsNao UmeiPatrick GonschorekChristina LamersKaycie DeyleRobert RiebenKeith E. CookAnne Angelillo-ScherrerChristian HeinisNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jonas Wilbs Xu-Dong Kong Simon J. Middendorp Raja Prince Alida Cooke Caitlin T. Demarest Mai M. Abdelhafez Kalliope Roberts Nao Umei Patrick Gonschorek Christina Lamers Kaycie Deyle Robert Rieben Keith E. Cook Anne Angelillo-Scherrer Christian Heinis Cyclic peptide FXII inhibitor provides safe anticoagulation in a thrombosis model and in artificial lungs
description	Inhibiting thrombosis without inducing bleeding is a major challenge for anticoagulant agents. Here the authors describe a synthetic FXIIa inhibitor able to efficiently prevent thrombosis in mice and suppress coagulation in artificial lungs in rabbits without increasing the risk of bleeding.
format	article
author	Jonas Wilbs Xu-Dong Kong Simon J. Middendorp Raja Prince Alida Cooke Caitlin T. Demarest Mai M. Abdelhafez Kalliope Roberts Nao Umei Patrick Gonschorek Christina Lamers Kaycie Deyle Robert Rieben Keith E. Cook Anne Angelillo-Scherrer Christian Heinis
author_facet	Jonas Wilbs Xu-Dong Kong Simon J. Middendorp Raja Prince Alida Cooke Caitlin T. Demarest Mai M. Abdelhafez Kalliope Roberts Nao Umei Patrick Gonschorek Christina Lamers Kaycie Deyle Robert Rieben Keith E. Cook Anne Angelillo-Scherrer Christian Heinis
author_sort	Jonas Wilbs
title	Cyclic peptide FXII inhibitor provides safe anticoagulation in a thrombosis model and in artificial lungs
title_short	Cyclic peptide FXII inhibitor provides safe anticoagulation in a thrombosis model and in artificial lungs
title_full	Cyclic peptide FXII inhibitor provides safe anticoagulation in a thrombosis model and in artificial lungs
title_fullStr	Cyclic peptide FXII inhibitor provides safe anticoagulation in a thrombosis model and in artificial lungs
title_full_unstemmed	Cyclic peptide FXII inhibitor provides safe anticoagulation in a thrombosis model and in artificial lungs
title_sort	cyclic peptide fxii inhibitor provides safe anticoagulation in a thrombosis model and in artificial lungs
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/1f9ddb75be1e4a398c1ff63698dcaa1b
work_keys_str_mv	AT jonaswilbs cyclicpeptidefxiiinhibitorprovidessafeanticoagulationinathrombosismodelandinartificiallungs AT xudongkong cyclicpeptidefxiiinhibitorprovidessafeanticoagulationinathrombosismodelandinartificiallungs AT simonjmiddendorp cyclicpeptidefxiiinhibitorprovidessafeanticoagulationinathrombosismodelandinartificiallungs AT rajaprince cyclicpeptidefxiiinhibitorprovidessafeanticoagulationinathrombosismodelandinartificiallungs AT alidacooke cyclicpeptidefxiiinhibitorprovidessafeanticoagulationinathrombosismodelandinartificiallungs AT caitlintdemarest cyclicpeptidefxiiinhibitorprovidessafeanticoagulationinathrombosismodelandinartificiallungs AT maimabdelhafez cyclicpeptidefxiiinhibitorprovidessafeanticoagulationinathrombosismodelandinartificiallungs AT kallioperoberts cyclicpeptidefxiiinhibitorprovidessafeanticoagulationinathrombosismodelandinartificiallungs AT naoumei cyclicpeptidefxiiinhibitorprovidessafeanticoagulationinathrombosismodelandinartificiallungs AT patrickgonschorek cyclicpeptidefxiiinhibitorprovidessafeanticoagulationinathrombosismodelandinartificiallungs AT christinalamers cyclicpeptidefxiiinhibitorprovidessafeanticoagulationinathrombosismodelandinartificiallungs AT kayciedeyle cyclicpeptidefxiiinhibitorprovidessafeanticoagulationinathrombosismodelandinartificiallungs AT robertrieben cyclicpeptidefxiiinhibitorprovidessafeanticoagulationinathrombosismodelandinartificiallungs AT keithecook cyclicpeptidefxiiinhibitorprovidessafeanticoagulationinathrombosismodelandinartificiallungs AT anneangelilloscherrer cyclicpeptidefxiiinhibitorprovidessafeanticoagulationinathrombosismodelandinartificiallungs AT christianheinis cyclicpeptidefxiiinhibitorprovidessafeanticoagulationinathrombosismodelandinartificiallungs
_version_	1718377548390334464

Cyclic peptide FXII inhibitor provides safe anticoagulation in a thrombosis model and in artificial lungs

Ejemplares similares