DNA methylation changes following narrative exposure therapy in a randomized controlled trial with female former child soldiers

Abstract The aftermath of traumatization lives on in the neural and epigenetic traces creating a momentum of affliction in the psychological and social realm. Can psychotherapy reorganise these memories through changes in DNA methylation signatures? Using a randomised controlled parallel group desig...

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Autores principales:	Samuel Carleial, Daniel Nätt, Eva Unternährer, Thomas Elbert, Katy Robjant, Sarah Wilker, Vanja Vukojevic, Iris-Tatjana Kolassa, Anja C. Zeller, Anke Koebach
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1fa2e2fb4c584ea7a2760c7c527cfd41
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spelling	oai:doaj.org-article:1fa2e2fb4c584ea7a2760c7c527cfd412021-12-02T18:33:51ZDNA methylation changes following narrative exposure therapy in a randomized controlled trial with female former child soldiers10.1038/s41598-021-98067-92045-2322https://doaj.org/article/1fa2e2fb4c584ea7a2760c7c527cfd412021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-98067-9https://doaj.org/toc/2045-2322Abstract The aftermath of traumatization lives on in the neural and epigenetic traces creating a momentum of affliction in the psychological and social realm. Can psychotherapy reorganise these memories through changes in DNA methylation signatures? Using a randomised controlled parallel group design, we examined methylome-wide changes in saliva samples of 84 female former child soldiers from Eastern DR Congo before and six months after Narrative Exposure Therapy. Treatment predicted differentially methylated positions (DMPs) related to ALCAM, RIPOR2, AFAP1 and MOCOS. In addition, treatment associations overlapped at gene level with baseline clinical and social outcomes. Treatment related DMPs are involved in memory formation—the key agent in trauma focused treatments—and enriched for molecular pathways commonly affected by trauma related disorders. Results were partially replicated in an independent sample of 53 female former child soldiers from Northern Uganda. Our results suggest a molecular impact of psychological treatment in women with war-related childhood trauma. Trial registration: Addressing Heightened Levels of Aggression in Traumatized Offenders With Psychotherapeutic Means (ClinicalTrials.gov Identifier: NCT02992561, 14/12/2016).Samuel CarleialDaniel NättEva UnternährerThomas ElbertKaty RobjantSarah WilkerVanja VukojevicIris-Tatjana KolassaAnja C. ZellerAnke KoebachNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Samuel Carleial Daniel Nätt Eva Unternährer Thomas Elbert Katy Robjant Sarah Wilker Vanja Vukojevic Iris-Tatjana Kolassa Anja C. Zeller Anke Koebach DNA methylation changes following narrative exposure therapy in a randomized controlled trial with female former child soldiers
description	Abstract The aftermath of traumatization lives on in the neural and epigenetic traces creating a momentum of affliction in the psychological and social realm. Can psychotherapy reorganise these memories through changes in DNA methylation signatures? Using a randomised controlled parallel group design, we examined methylome-wide changes in saliva samples of 84 female former child soldiers from Eastern DR Congo before and six months after Narrative Exposure Therapy. Treatment predicted differentially methylated positions (DMPs) related to ALCAM, RIPOR2, AFAP1 and MOCOS. In addition, treatment associations overlapped at gene level with baseline clinical and social outcomes. Treatment related DMPs are involved in memory formation—the key agent in trauma focused treatments—and enriched for molecular pathways commonly affected by trauma related disorders. Results were partially replicated in an independent sample of 53 female former child soldiers from Northern Uganda. Our results suggest a molecular impact of psychological treatment in women with war-related childhood trauma. Trial registration: Addressing Heightened Levels of Aggression in Traumatized Offenders With Psychotherapeutic Means (ClinicalTrials.gov Identifier: NCT02992561, 14/12/2016).
format	article
author	Samuel Carleial Daniel Nätt Eva Unternährer Thomas Elbert Katy Robjant Sarah Wilker Vanja Vukojevic Iris-Tatjana Kolassa Anja C. Zeller Anke Koebach
author_facet	Samuel Carleial Daniel Nätt Eva Unternährer Thomas Elbert Katy Robjant Sarah Wilker Vanja Vukojevic Iris-Tatjana Kolassa Anja C. Zeller Anke Koebach
author_sort	Samuel Carleial
title	DNA methylation changes following narrative exposure therapy in a randomized controlled trial with female former child soldiers
title_short	DNA methylation changes following narrative exposure therapy in a randomized controlled trial with female former child soldiers
title_full	DNA methylation changes following narrative exposure therapy in a randomized controlled trial with female former child soldiers
title_fullStr	DNA methylation changes following narrative exposure therapy in a randomized controlled trial with female former child soldiers
title_full_unstemmed	DNA methylation changes following narrative exposure therapy in a randomized controlled trial with female former child soldiers
title_sort	dna methylation changes following narrative exposure therapy in a randomized controlled trial with female former child soldiers
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/1fa2e2fb4c584ea7a2760c7c527cfd41
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DNA methylation changes following narrative exposure therapy in a randomized controlled trial with female former child soldiers

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