Involvement of MCH-oxytocin neural relay within the hypothalamus in murine nursing behavior

Abstract Multiple sequential actions, performed during parental behaviors, are essential elements of reproduction in mammalian species. We showed that neurons expressing melanin concentrating hormone (MCH) in the lateral hypothalamic area (LHA) are more active in rodents of both sexes when exhibitin...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Yoko Kato, Harumi Katsumata, Ayumu Inutsuka, Akihiro Yamanaka, Tatsushi Onaka, Shiro Minami, Chitose Orikasa
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1fa41d2e26f54ffb91c3fd373ce3fce8
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:1fa41d2e26f54ffb91c3fd373ce3fce8
record_format	dspace
spelling	oai:doaj.org-article:1fa41d2e26f54ffb91c3fd373ce3fce82021-12-02T13:30:17ZInvolvement of MCH-oxytocin neural relay within the hypothalamus in murine nursing behavior10.1038/s41598-021-82773-52045-2322https://doaj.org/article/1fa41d2e26f54ffb91c3fd373ce3fce82021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-82773-5https://doaj.org/toc/2045-2322Abstract Multiple sequential actions, performed during parental behaviors, are essential elements of reproduction in mammalian species. We showed that neurons expressing melanin concentrating hormone (MCH) in the lateral hypothalamic area (LHA) are more active in rodents of both sexes when exhibiting parental nursing behavior. Genetic ablation of the LHA-MCH neurons impaired maternal nursing. The post-birth survival rate was lower in pups born to female mice with congenitally ablated MCH neurons under control of tet-off system, exhibiting reduced crouching behavior. Virgin female and male mice with ablated MCH neurons were less interested in pups and maternal care. Chemogenetic and optogenetic stimulation of LHA-MCH neurons induced parental nursing in virgin female and male mice. LHA-MCH GABAergic neurons project fibres to the paraventricular hypothalamic nucleus (PVN) neurons. Optogenetic stimulation of PVN induces nursing crouching behavior along with increasing plasma oxytocin levels. The hypothalamic MCH neural relays play important functional roles in parental nursing behavior in female and male mice.Yoko KatoHarumi KatsumataAyumu InutsukaAkihiro YamanakaTatsushi OnakaShiro MinamiChitose OrikasaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yoko Kato Harumi Katsumata Ayumu Inutsuka Akihiro Yamanaka Tatsushi Onaka Shiro Minami Chitose Orikasa Involvement of MCH-oxytocin neural relay within the hypothalamus in murine nursing behavior
description	Abstract Multiple sequential actions, performed during parental behaviors, are essential elements of reproduction in mammalian species. We showed that neurons expressing melanin concentrating hormone (MCH) in the lateral hypothalamic area (LHA) are more active in rodents of both sexes when exhibiting parental nursing behavior. Genetic ablation of the LHA-MCH neurons impaired maternal nursing. The post-birth survival rate was lower in pups born to female mice with congenitally ablated MCH neurons under control of tet-off system, exhibiting reduced crouching behavior. Virgin female and male mice with ablated MCH neurons were less interested in pups and maternal care. Chemogenetic and optogenetic stimulation of LHA-MCH neurons induced parental nursing in virgin female and male mice. LHA-MCH GABAergic neurons project fibres to the paraventricular hypothalamic nucleus (PVN) neurons. Optogenetic stimulation of PVN induces nursing crouching behavior along with increasing plasma oxytocin levels. The hypothalamic MCH neural relays play important functional roles in parental nursing behavior in female and male mice.
format	article
author	Yoko Kato Harumi Katsumata Ayumu Inutsuka Akihiro Yamanaka Tatsushi Onaka Shiro Minami Chitose Orikasa
author_facet	Yoko Kato Harumi Katsumata Ayumu Inutsuka Akihiro Yamanaka Tatsushi Onaka Shiro Minami Chitose Orikasa
author_sort	Yoko Kato
title	Involvement of MCH-oxytocin neural relay within the hypothalamus in murine nursing behavior
title_short	Involvement of MCH-oxytocin neural relay within the hypothalamus in murine nursing behavior
title_full	Involvement of MCH-oxytocin neural relay within the hypothalamus in murine nursing behavior
title_fullStr	Involvement of MCH-oxytocin neural relay within the hypothalamus in murine nursing behavior
title_full_unstemmed	Involvement of MCH-oxytocin neural relay within the hypothalamus in murine nursing behavior
title_sort	involvement of mch-oxytocin neural relay within the hypothalamus in murine nursing behavior
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/1fa41d2e26f54ffb91c3fd373ce3fce8
work_keys_str_mv	AT yokokato involvementofmchoxytocinneuralrelaywithinthehypothalamusinmurinenursingbehavior AT harumikatsumata involvementofmchoxytocinneuralrelaywithinthehypothalamusinmurinenursingbehavior AT ayumuinutsuka involvementofmchoxytocinneuralrelaywithinthehypothalamusinmurinenursingbehavior AT akihiroyamanaka involvementofmchoxytocinneuralrelaywithinthehypothalamusinmurinenursingbehavior AT tatsushionaka involvementofmchoxytocinneuralrelaywithinthehypothalamusinmurinenursingbehavior AT shirominami involvementofmchoxytocinneuralrelaywithinthehypothalamusinmurinenursingbehavior AT chitoseorikasa involvementofmchoxytocinneuralrelaywithinthehypothalamusinmurinenursingbehavior
_version_	1718392902067945472

Involvement of MCH-oxytocin neural relay within the hypothalamus in murine nursing behavior

Ejemplares similares