CYTOKINES AND HERPESVIRUSES IN CHILDREN WITH MULTIPLE SCLEROSIS

It was determined earlier (G.P. Ivanova, 2012) that a chronic course of leukoencephalitis in teenagers caused by inadequate response of cytokine system to the combination of two herpesviruses (HV) — EBV and HHV-6, leads to the development of multiple sclerosis (MS) in 44% of cases. The research obje...

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Autores principales:	G. F. Zheleznikova, N. V. Skripchenko, G. P. Ivanova, A. V. Surovtseva, N. E. Monakhova
Formato:	article
Lenguaje:	RU
Publicado:	Sankt-Peterburg : NIIÈM imeni Pastera 2016
Materias:	multiple sclerosis herpesviruses immune responses cytokines ebv-infection children Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/1fa932b0a3224e08ade7316076cd3eeb
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spelling	oai:doaj.org-article:1fa932b0a3224e08ade7316076cd3eeb2021-11-22T07:09:47ZCYTOKINES AND HERPESVIRUSES IN CHILDREN WITH MULTIPLE SCLEROSIS2220-76192313-739810.15789/2220-7619-2015-4-349-358https://doaj.org/article/1fa932b0a3224e08ade7316076cd3eeb2016-02-01T00:00:00Zhttps://www.iimmun.ru/iimm/article/view/352https://doaj.org/toc/2220-7619https://doaj.org/toc/2313-7398It was determined earlier (G.P. Ivanova, 2012) that a chronic course of leukoencephalitis in teenagers caused by inadequate response of cytokine system to the combination of two herpesviruses (HV) — EBV and HHV-6, leads to the development of multiple sclerosis (MS) in 44% of cases. The research objective was to characterize the cytokine response in children with MS with simultaneous screening of the presence of active HV infections. 39 children with the diagnosis “MS” were under observation, 34 of them had relapsing-remitting (RR) MS, and 5 children had a progressing course of MS (PMS). Concentration of cytokines IL-1β, IL-6, IL-8, IL-10, IFNα, IFNγ, and IL-4 was identified in blood serum and cerebrospinal liquid (CSF) by enzyme-linked immunosorbent assay, HV DNA was revealed by PCR. Cytokine status in children with MS had some differences depending on the phase of the disease, clinical severity of the relapse and the course of MS. The relapse phase of RRMS was associated with the accumulation of IL-8, IL-10, and IL-6 in the blood, and index IFNγ/IL-4 modulations in accordance with the clinical severity of the relapse. A severe aggravation of the disease in children with PMS was accompanied by the increase of IL-8 system response. HV DNA was revealed in 27 patients from 39 ones (69%) in blood and in 17 patients (44%) in CSF with the predominance of EBV (93%), frequently in combination with HHV-6. During an acute period the frequency of HV DNA identification increased 2–3 times to compare with the remission period. Unlike children with RRMS, a mixed-infection of 3–4 herpes viruses was revealed in all 5 patients with PMS. According to the results summary it is possible to make a conclusion that HV-infection has an important role in MS pathogenesis in teenagers, taking part in the aggravation and progression of the disease by its effect on the cytokine system response. EBV-infection dominates among HV, however the risk of MS development increases to a great extent in the case of EBV association with another lymphotropic virus — HHV-6.G. F. ZheleznikovaN. V. SkripchenkoG. P. IvanovaA. V. SurovtsevaN. E. MonakhovaSankt-Peterburg : NIIÈM imeni Pasteraarticlemultiple sclerosisherpesvirusesimmune responsescytokinesebv-infectionchildrenInfectious and parasitic diseasesRC109-216RUInfekciâ i Immunitet, Vol 5, Iss 4, Pp 349-358 (2016)
institution	DOAJ
collection	DOAJ
language	RU
topic	multiple sclerosis herpesviruses immune responses cytokines ebv-infection children Infectious and parasitic diseases RC109-216
spellingShingle	multiple sclerosis herpesviruses immune responses cytokines ebv-infection children Infectious and parasitic diseases RC109-216 G. F. Zheleznikova N. V. Skripchenko G. P. Ivanova A. V. Surovtseva N. E. Monakhova CYTOKINES AND HERPESVIRUSES IN CHILDREN WITH MULTIPLE SCLEROSIS
description	It was determined earlier (G.P. Ivanova, 2012) that a chronic course of leukoencephalitis in teenagers caused by inadequate response of cytokine system to the combination of two herpesviruses (HV) — EBV and HHV-6, leads to the development of multiple sclerosis (MS) in 44% of cases. The research objective was to characterize the cytokine response in children with MS with simultaneous screening of the presence of active HV infections. 39 children with the diagnosis “MS” were under observation, 34 of them had relapsing-remitting (RR) MS, and 5 children had a progressing course of MS (PMS). Concentration of cytokines IL-1β, IL-6, IL-8, IL-10, IFNα, IFNγ, and IL-4 was identified in blood serum and cerebrospinal liquid (CSF) by enzyme-linked immunosorbent assay, HV DNA was revealed by PCR. Cytokine status in children with MS had some differences depending on the phase of the disease, clinical severity of the relapse and the course of MS. The relapse phase of RRMS was associated with the accumulation of IL-8, IL-10, and IL-6 in the blood, and index IFNγ/IL-4 modulations in accordance with the clinical severity of the relapse. A severe aggravation of the disease in children with PMS was accompanied by the increase of IL-8 system response. HV DNA was revealed in 27 patients from 39 ones (69%) in blood and in 17 patients (44%) in CSF with the predominance of EBV (93%), frequently in combination with HHV-6. During an acute period the frequency of HV DNA identification increased 2–3 times to compare with the remission period. Unlike children with RRMS, a mixed-infection of 3–4 herpes viruses was revealed in all 5 patients with PMS. According to the results summary it is possible to make a conclusion that HV-infection has an important role in MS pathogenesis in teenagers, taking part in the aggravation and progression of the disease by its effect on the cytokine system response. EBV-infection dominates among HV, however the risk of MS development increases to a great extent in the case of EBV association with another lymphotropic virus — HHV-6.
format	article
author	G. F. Zheleznikova N. V. Skripchenko G. P. Ivanova A. V. Surovtseva N. E. Monakhova
author_facet	G. F. Zheleznikova N. V. Skripchenko G. P. Ivanova A. V. Surovtseva N. E. Monakhova
author_sort	G. F. Zheleznikova
title	CYTOKINES AND HERPESVIRUSES IN CHILDREN WITH MULTIPLE SCLEROSIS
title_short	CYTOKINES AND HERPESVIRUSES IN CHILDREN WITH MULTIPLE SCLEROSIS
title_full	CYTOKINES AND HERPESVIRUSES IN CHILDREN WITH MULTIPLE SCLEROSIS
title_fullStr	CYTOKINES AND HERPESVIRUSES IN CHILDREN WITH MULTIPLE SCLEROSIS
title_full_unstemmed	CYTOKINES AND HERPESVIRUSES IN CHILDREN WITH MULTIPLE SCLEROSIS
title_sort	cytokines and herpesviruses in children with multiple sclerosis
publisher	Sankt-Peterburg : NIIÈM imeni Pastera
publishDate	2016
url	https://doaj.org/article/1fa932b0a3224e08ade7316076cd3eeb
work_keys_str_mv	AT gfzheleznikova cytokinesandherpesvirusesinchildrenwithmultiplesclerosis AT nvskripchenko cytokinesandherpesvirusesinchildrenwithmultiplesclerosis AT gpivanova cytokinesandherpesvirusesinchildrenwithmultiplesclerosis AT avsurovtseva cytokinesandherpesvirusesinchildrenwithmultiplesclerosis AT nemonakhova cytokinesandherpesvirusesinchildrenwithmultiplesclerosis
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CYTOKINES AND HERPESVIRUSES IN CHILDREN WITH MULTIPLE SCLEROSIS

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