Simulation and modeling of physiological processes of vital organs in organ-on-a-chip biosystem

The limited adequacy of animal cell cultures and models to mimic the complexity of human bodies in laboratory conditions has emphasized researchers to find its quintessential bioelectronic alternative with improved competence. In this regard, tissue engineering has emerged as one of the most precise...

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Autores principales:	Sadegh Seidi, Aziz Eftekhari, Ameer Khusro, Reza Shiri Heris, Muhammad Umar Khayam Sahibzada, Márió Gajdács
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2022
Materias:	Biomaterials Microfluidics Modeling Organ-on-a-chip Tissue engineering Science (General) Q1-390
Acceso en línea:	https://doaj.org/article/1faa069d354f4200a6c390ed5e153e3b
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spelling	oai:doaj.org-article:1faa069d354f4200a6c390ed5e153e3b2021-11-28T04:28:41ZSimulation and modeling of physiological processes of vital organs in organ-on-a-chip biosystem1018-364710.1016/j.jksus.2021.101710https://doaj.org/article/1faa069d354f4200a6c390ed5e153e3b2022-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1018364721003724https://doaj.org/toc/1018-3647The limited adequacy of animal cell cultures and models to mimic the complexity of human bodies in laboratory conditions has emphasized researchers to find its quintessential bioelectronic alternative with improved competence. In this regard, tissue engineering has emerged as one of the most precise biomaterial technologies in terms of creating new tissues to model vital organs. An organ-on-a-chip biosystem has shown a plethora of applications in tissue engineering and drug delivery. Organ-on-a-chip is a microfluidic device that provides a completely controlled microenvironment, similar to the natural tissues for the cultured cells of an organ, by amalgamating cell biology and biomaterial science. The device contains several microchambers and microchannels embedded in a layer of a biocompatible polymer, such as polydimethylsiloxane. Microchambers house the cells, while microchannels provide nutrients and growth factors. Over the past few years, organ-on-a-chip technology has displayed ample applications in the field of biomedicine, not only by simulating the normal functions of disparate organs, but also by understanding the inter-relation between diversified systems. In this review, we have spotlighted recent advancements and applications of organ-on-a-chip biosystems to construct physiological models for the heart, lung, kidney, liver, and brain. Part of this review is also concentrated on abridging the desperate essentiality as well as future perspectives of organ-on-a-chip technology in biomedicine, disease modeling, and drug development process.Sadegh SeidiAziz EftekhariAmeer KhusroReza Shiri HerisMuhammad Umar Khayam SahibzadaMárió GajdácsElsevierarticleBiomaterialsMicrofluidicsModelingOrgan-on-a-chipTissue engineeringScience (General)Q1-390ENJournal of King Saud University: Science, Vol 34, Iss 1, Pp 101710- (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biomaterials Microfluidics Modeling Organ-on-a-chip Tissue engineering Science (General) Q1-390
spellingShingle	Biomaterials Microfluidics Modeling Organ-on-a-chip Tissue engineering Science (General) Q1-390 Sadegh Seidi Aziz Eftekhari Ameer Khusro Reza Shiri Heris Muhammad Umar Khayam Sahibzada Márió Gajdács Simulation and modeling of physiological processes of vital organs in organ-on-a-chip biosystem
description	The limited adequacy of animal cell cultures and models to mimic the complexity of human bodies in laboratory conditions has emphasized researchers to find its quintessential bioelectronic alternative with improved competence. In this regard, tissue engineering has emerged as one of the most precise biomaterial technologies in terms of creating new tissues to model vital organs. An organ-on-a-chip biosystem has shown a plethora of applications in tissue engineering and drug delivery. Organ-on-a-chip is a microfluidic device that provides a completely controlled microenvironment, similar to the natural tissues for the cultured cells of an organ, by amalgamating cell biology and biomaterial science. The device contains several microchambers and microchannels embedded in a layer of a biocompatible polymer, such as polydimethylsiloxane. Microchambers house the cells, while microchannels provide nutrients and growth factors. Over the past few years, organ-on-a-chip technology has displayed ample applications in the field of biomedicine, not only by simulating the normal functions of disparate organs, but also by understanding the inter-relation between diversified systems. In this review, we have spotlighted recent advancements and applications of organ-on-a-chip biosystems to construct physiological models for the heart, lung, kidney, liver, and brain. Part of this review is also concentrated on abridging the desperate essentiality as well as future perspectives of organ-on-a-chip technology in biomedicine, disease modeling, and drug development process.
format	article
author	Sadegh Seidi Aziz Eftekhari Ameer Khusro Reza Shiri Heris Muhammad Umar Khayam Sahibzada Márió Gajdács
author_facet	Sadegh Seidi Aziz Eftekhari Ameer Khusro Reza Shiri Heris Muhammad Umar Khayam Sahibzada Márió Gajdács
author_sort	Sadegh Seidi
title	Simulation and modeling of physiological processes of vital organs in organ-on-a-chip biosystem
title_short	Simulation and modeling of physiological processes of vital organs in organ-on-a-chip biosystem
title_full	Simulation and modeling of physiological processes of vital organs in organ-on-a-chip biosystem
title_fullStr	Simulation and modeling of physiological processes of vital organs in organ-on-a-chip biosystem
title_full_unstemmed	Simulation and modeling of physiological processes of vital organs in organ-on-a-chip biosystem
title_sort	simulation and modeling of physiological processes of vital organs in organ-on-a-chip biosystem
publisher	Elsevier
publishDate	2022
url	https://doaj.org/article/1faa069d354f4200a6c390ed5e153e3b
work_keys_str_mv	AT sadeghseidi simulationandmodelingofphysiologicalprocessesofvitalorgansinorganonachipbiosystem AT azizeftekhari simulationandmodelingofphysiologicalprocessesofvitalorgansinorganonachipbiosystem AT ameerkhusro simulationandmodelingofphysiologicalprocessesofvitalorgansinorganonachipbiosystem AT rezashiriheris simulationandmodelingofphysiologicalprocessesofvitalorgansinorganonachipbiosystem AT muhammadumarkhayamsahibzada simulationandmodelingofphysiologicalprocessesofvitalorgansinorganonachipbiosystem AT mariogajdacs simulationandmodelingofphysiologicalprocessesofvitalorgansinorganonachipbiosystem
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Simulation and modeling of physiological processes of vital organs in organ-on-a-chip biosystem

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