Targeting glutamine-addiction and overcoming CDK4/6 inhibitor resistance in human esophageal squamous cell carcinoma

A subset of esophageal squamous cell carcinoma harbors dysregulated Fbxo4- cyclin D1 axis. Here, the authors show that the dysregulation of Fbxo4-cyclin D1 leads to mitochondrial dysfunction and glutamine addiction rendering these tumors susceptible to metabolic inhibitors even when resistant to CDK...

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Autores principales:	Shuo Qie, Akihiro Yoshida, Stuart Parnham, Natalia Oleinik, Gyda C. Beeson, Craig C. Beeson, Besim Ogretmen, Adam J. Bass, Kwok-Kin Wong, Anil K. Rustgi, J. Alan Diehl
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1faab1692f4b47f8a3c1390b1123f127
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spelling	oai:doaj.org-article:1faab1692f4b47f8a3c1390b1123f1272021-12-02T16:57:10ZTargeting glutamine-addiction and overcoming CDK4/6 inhibitor resistance in human esophageal squamous cell carcinoma10.1038/s41467-019-09179-w2041-1723https://doaj.org/article/1faab1692f4b47f8a3c1390b1123f1272019-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09179-whttps://doaj.org/toc/2041-1723A subset of esophageal squamous cell carcinoma harbors dysregulated Fbxo4- cyclin D1 axis. Here, the authors show that the dysregulation of Fbxo4-cyclin D1 leads to mitochondrial dysfunction and glutamine addiction rendering these tumors susceptible to metabolic inhibitors even when resistant to CDK4/6 inhibitors.Shuo QieAkihiro YoshidaStuart ParnhamNatalia OleinikGyda C. BeesonCraig C. BeesonBesim OgretmenAdam J. BassKwok-Kin WongAnil K. RustgiJ. Alan DiehlNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Shuo Qie Akihiro Yoshida Stuart Parnham Natalia Oleinik Gyda C. Beeson Craig C. Beeson Besim Ogretmen Adam J. Bass Kwok-Kin Wong Anil K. Rustgi J. Alan Diehl Targeting glutamine-addiction and overcoming CDK4/6 inhibitor resistance in human esophageal squamous cell carcinoma
description	A subset of esophageal squamous cell carcinoma harbors dysregulated Fbxo4- cyclin D1 axis. Here, the authors show that the dysregulation of Fbxo4-cyclin D1 leads to mitochondrial dysfunction and glutamine addiction rendering these tumors susceptible to metabolic inhibitors even when resistant to CDK4/6 inhibitors.
format	article
author	Shuo Qie Akihiro Yoshida Stuart Parnham Natalia Oleinik Gyda C. Beeson Craig C. Beeson Besim Ogretmen Adam J. Bass Kwok-Kin Wong Anil K. Rustgi J. Alan Diehl
author_facet	Shuo Qie Akihiro Yoshida Stuart Parnham Natalia Oleinik Gyda C. Beeson Craig C. Beeson Besim Ogretmen Adam J. Bass Kwok-Kin Wong Anil K. Rustgi J. Alan Diehl
author_sort	Shuo Qie
title	Targeting glutamine-addiction and overcoming CDK4/6 inhibitor resistance in human esophageal squamous cell carcinoma
title_short	Targeting glutamine-addiction and overcoming CDK4/6 inhibitor resistance in human esophageal squamous cell carcinoma
title_full	Targeting glutamine-addiction and overcoming CDK4/6 inhibitor resistance in human esophageal squamous cell carcinoma
title_fullStr	Targeting glutamine-addiction and overcoming CDK4/6 inhibitor resistance in human esophageal squamous cell carcinoma
title_full_unstemmed	Targeting glutamine-addiction and overcoming CDK4/6 inhibitor resistance in human esophageal squamous cell carcinoma
title_sort	targeting glutamine-addiction and overcoming cdk4/6 inhibitor resistance in human esophageal squamous cell carcinoma
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/1faab1692f4b47f8a3c1390b1123f127
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Targeting glutamine-addiction and overcoming CDK4/6 inhibitor resistance in human esophageal squamous cell carcinoma

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