Targeting glutamine-addiction and overcoming CDK4/6 inhibitor resistance in human esophageal squamous cell carcinoma

Targeting glutamine-addiction and overcoming CDK4/6 inhibitor resistance in human esophageal squamous cell carcinoma

A subset of esophageal squamous cell carcinoma harbors dysregulated Fbxo4- cyclin D1 axis. Here, the authors show that the dysregulation of Fbxo4-cyclin D1 leads to mitochondrial dysfunction and glutamine addiction rendering these tumors susceptible to metabolic inhibitors even when resistant to CDK...

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Autores principales: Shuo Qie, Akihiro Yoshida, Stuart Parnham, Natalia Oleinik, Gyda C. Beeson, Craig C. Beeson, Besim Ogretmen, Adam J. Bass, Kwok-Kin Wong, Anil K. Rustgi, J. Alan Diehl
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Science
Q
Acceso en línea:https://doaj.org/article/1faab1692f4b47f8a3c1390b1123f127
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