A Role for the Bone Marrow Microenvironment in Drug Resistance of Acute Myeloid Leukemia

Acute myeloid leukemia (AML) is a heterogeneous disease with a poor prognosis and remarkable resistance to chemotherapeutic agents. Understanding resistance mechanisms against currently available drugs helps to recognize the therapeutic obstacles. Various mechanisms of resistance to chemotherapy or...

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Autores principales:	Seyed Mohammadreza Bolandi, Mahdi Pakjoo, Peyman Beigi, Mohammad Kiani, Ali Allahgholipour, Negar Goudarzi, Jamshid S. Khorashad, Anna M. Eiring
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	drug resistance acute myeloid leukemia bone marrow microenvironment leukemic stem cell Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/1faed8829cc941118209d54de522aa73
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spelling	oai:doaj.org-article:1faed8829cc941118209d54de522aa732021-11-25T17:07:42ZA Role for the Bone Marrow Microenvironment in Drug Resistance of Acute Myeloid Leukemia10.3390/cells101128332073-4409https://doaj.org/article/1faed8829cc941118209d54de522aa732021-10-01T00:00:00Zhttps://www.mdpi.com/2073-4409/10/11/2833https://doaj.org/toc/2073-4409Acute myeloid leukemia (AML) is a heterogeneous disease with a poor prognosis and remarkable resistance to chemotherapeutic agents. Understanding resistance mechanisms against currently available drugs helps to recognize the therapeutic obstacles. Various mechanisms of resistance to chemotherapy or targeted inhibitors have been described for AML cells, including a role for the bone marrow niche in both the initiation and persistence of the disease, and in drug resistance of the leukemic stem cell (LSC) population. The BM niche supports LSC survival through direct and indirect interactions among the stromal cells, hematopoietic stem/progenitor cells, and leukemic cells. Additionally, the BM niche mediates changes in metabolic and signal pathway activation due to the acquisition of new mutations or selection and expansion of a minor clone. This review briefly discusses the role of the BM microenvironment and metabolic pathways in resistance to therapy, as discovered through AML clinical studies or cell line and animal models.Seyed Mohammadreza BolandiMahdi PakjooPeyman BeigiMohammad KianiAli AllahgholipourNegar GoudarziJamshid S. KhorashadAnna M. EiringMDPI AGarticledrug resistanceacute myeloid leukemiabone marrow microenvironmentleukemic stem cellBiology (General)QH301-705.5ENCells, Vol 10, Iss 2833, p 2833 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	drug resistance acute myeloid leukemia bone marrow microenvironment leukemic stem cell Biology (General) QH301-705.5
spellingShingle	drug resistance acute myeloid leukemia bone marrow microenvironment leukemic stem cell Biology (General) QH301-705.5 Seyed Mohammadreza Bolandi Mahdi Pakjoo Peyman Beigi Mohammad Kiani Ali Allahgholipour Negar Goudarzi Jamshid S. Khorashad Anna M. Eiring A Role for the Bone Marrow Microenvironment in Drug Resistance of Acute Myeloid Leukemia
description	Acute myeloid leukemia (AML) is a heterogeneous disease with a poor prognosis and remarkable resistance to chemotherapeutic agents. Understanding resistance mechanisms against currently available drugs helps to recognize the therapeutic obstacles. Various mechanisms of resistance to chemotherapy or targeted inhibitors have been described for AML cells, including a role for the bone marrow niche in both the initiation and persistence of the disease, and in drug resistance of the leukemic stem cell (LSC) population. The BM niche supports LSC survival through direct and indirect interactions among the stromal cells, hematopoietic stem/progenitor cells, and leukemic cells. Additionally, the BM niche mediates changes in metabolic and signal pathway activation due to the acquisition of new mutations or selection and expansion of a minor clone. This review briefly discusses the role of the BM microenvironment and metabolic pathways in resistance to therapy, as discovered through AML clinical studies or cell line and animal models.
format	article
author	Seyed Mohammadreza Bolandi Mahdi Pakjoo Peyman Beigi Mohammad Kiani Ali Allahgholipour Negar Goudarzi Jamshid S. Khorashad Anna M. Eiring
author_facet	Seyed Mohammadreza Bolandi Mahdi Pakjoo Peyman Beigi Mohammad Kiani Ali Allahgholipour Negar Goudarzi Jamshid S. Khorashad Anna M. Eiring
author_sort	Seyed Mohammadreza Bolandi
title	A Role for the Bone Marrow Microenvironment in Drug Resistance of Acute Myeloid Leukemia
title_short	A Role for the Bone Marrow Microenvironment in Drug Resistance of Acute Myeloid Leukemia
title_full	A Role for the Bone Marrow Microenvironment in Drug Resistance of Acute Myeloid Leukemia
title_fullStr	A Role for the Bone Marrow Microenvironment in Drug Resistance of Acute Myeloid Leukemia
title_full_unstemmed	A Role for the Bone Marrow Microenvironment in Drug Resistance of Acute Myeloid Leukemia
title_sort	role for the bone marrow microenvironment in drug resistance of acute myeloid leukemia
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/1faed8829cc941118209d54de522aa73
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A Role for the Bone Marrow Microenvironment in Drug Resistance of Acute Myeloid Leukemia

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